Non-functional adrenocortical adenoma: A unique case of combination with myelolipoma and endothelial cysts

Yamada, Sohsuke; Tanimoto, Akihide; Wang, Ke-Yong; Ding, Yan; Guo, Xin; Shimajiri, Shohei; Sasano, Hironobu; Sasaguri, Yasuyuki

doi:10.1016/j.prp.2010.07.008

Cited by 12 publications

(9 citation statements)

References 19 publications

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“…This is not surprising as these tumours are common tumours in adrenal gland. In the literature, approximately 20 cases have been documented (Caliumi et al 2004, Ong et al 2007, Lu et al 2008, Yamada et al 2011). Lu and coworkers analysed 17 cases reported in the literature and noted that they were often noted in females (male-to-female ratio = 1:3) and in the left adrenal gland (Lu et al 2008).…”

Section: :3mentioning

confidence: 99%

Lipomatous tumours in adrenal gland: WHO updates and clinical implications

Lam¹

2017

Endocrine-Related Cancer

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Adrenal lipomatous tumour is a group of adrenal tumours with a significant component of adipose tissue. According to the current World Health Organization (WHO) classification of tumours of endocrine organs, adrenal myelolipoma is the only entity amongst the group of tumours being described. In the literature, other more recently documented adrenal lipomatous tumours included 24 lipomas, 32 teratomas and 16 angiomyolipomas. Rare fatty tumours of the adrenal gland comprised liposarcoma, hibernoma, adrenocortical tumours with fat component and rare adrenal tumours with fat component. Myelolipoma comprises approximately 3% of primary adrenal tumour. It is noted more commonly in females and in the right adrenal gland. Approximately 40 bilateral myelolipomas were reported. The tumour is most frequently recorded in patients between fifth and seventh decades of life. Adrenal lipomas are often seen in males and in the right adrenal gland. They were commonly noted in patients in the sixth decade of life. The diagnosis could only be possible on examination of the surgically removed specimen. Adrenal teratomas were more common in females and with a bimodal age distribution. Slightly over 60% of the patients with adrenal teratoma are symptomatic. Adrenal angiomyolipomas were often symptomatic, more common in females and in the fifth decades of life. To conclude, adrenal lipomatous tumour is uncommon. They are often benign and non-functional. It is important to recognize the features of this group of lipomatous tumours in the adrenal gland as they are being detected on increasing incidence as a result of the wide-spread use of modern imaging modalities.

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Section: :3mentioning

confidence: 99%

Lipomatous tumours in adrenal gland: WHO updates and clinical implications

Lam¹

2017

Endocrine-Related Cancer

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“…The cut surface is variegated with yellow and brown areas, depending on the ratio of adipose tissue and bone marrow tissue components 17 There are different hypotheses about the pathogenesis of myelolipoma. These may be summarized as 1) necrosis and hemorrhage stimulating the hematopoietic cells to migrate to the adrenal gland, 2) embolization of bone marrow, 3) misplacement of myeloid cells during embryogenesis, and 4) metaplastic changes of adrenal stromal cells 11 . Masugi et al suggested that high steroid hormone levels in the adrenal cortex suppress the production of a series of cytokines that stimulate interstitial cells such as fibroblasts which have metaplastic potential 19 .…”

Section: Discussionmentioning

confidence: 99%

Adrenokortikal adenomda myelolipomatöz değişiklikler

Fırat¹,

Eryiğit

Yener

et al. 2019

Cukurova Medical Journal

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Öz Myelolipoma is a rare benign tumor which is generally detected incidentally. The tumor consists of mature fat tissue and hematopoietic cells that resemble bone marrow. The coexistence of myelolipoma and nonfunctional adrenocortical adenoma in the same gland is exceedingly rare. We herein present two cases of adrenal myelolipoma in association with non-functional adrenocortical adenoma in left adrenal gland of a 62-yearold woman and non-functional adrenocortical adenoma combined with myelolipoma and endothelial cyst, in right adrenal gland of a 73-years-old man. Microscopically, in the central of the tumor, there was a myelolipomatous area composed of adipocytes and hematopoietic cells surrounded by sheets of adenoma cells. The histopathological diagnosis was "myelolipomatous changes within a non-functional adrenocortical adenoma". The cases are presented here with their rarity and pathological differential diagnosis. Myelolipoma is a rare benign tumor which is generally detected incidentally. The tumor consists of mature fat tissue and hematopoietic cells that resemble bone marrow. The coexistence of myelolipoma and nonfunctional adrenocortical adenoma in the same gland is exceedingly rare. We herein present two cases of adrenal myelolipoma in association with non-functional adrenocortical adenoma in left adrenal gland of a 62-yearold woman and non-functional adrenocortical adenoma combined with myelolipoma and endothelial cyst, in right adrenal gland of a 73-years-old man. Microscopically, in the central of the tumor, there was a myelolipomatous area composed of adipocytes and hematopoietic cells surrounded by sheets of adenoma cells. The histopathological diagnosis was "myelolipomatous changes within a non-functional adrenocortical adenoma". The cases are presented here with their rarity and pathological differential diagnosis.

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“…19,21 Indeed, it has been proposed that due to the latent risk of rupture and hemorrhage, tumours less than 3.5 cm should also be treated surgically, especially in light minimally invasive surgical techniques. 28,29 The possibility of secondary infection or malignant transformation associated with tumour growth is another reason to adopt early tumour excision to achieve a better prognosis. In our study, the diameter of all the tumours was more than 3.5 cm.…”

Section: Discussionmentioning

confidence: 99%

The diagnosis and treatment of primary adrenal lipomatous tumors in Chinese patients: a 31-year follow-up study

Zhao

Sun

Xie

et al. 2014

CUAJ

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Results: A total of 73 cases of primary ALTs in 22 men and 51 women (mean age 51.1±14.2 years) were reviewed. The ALTs included 65 myelolipomas (89.0%), 3 lipomas (4.1%), 2 angiomyolipomas (2.7%), 2 teratomas (2.7%), and 1 liposarcoma (1.4%). Of the total 73 patients, 24 of them had tumours in the left adrenal gland, 47 in the right gland and 2 had bilateral tumours. In total, 51 patients underwent open surgery and 22 laparoscopic surgery. Conclusion: Myelolipoma is predominant among the various types of lipomatous adrenal gland tumours; it accounts for about 90% of all cases. Surgery is recommended for tumours ≥3.5 cm in diameter, for all cases of symptomatic tumour, and for cases of teratoma or liposarcoma identified by preoperative imaging.

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Non-functional adrenocortical adenoma: A unique case of combination with myelolipoma and endothelial cysts

Cited by 12 publications

References 19 publications

Lipomatous tumours in adrenal gland: WHO updates and clinical implications

Lipomatous tumours in adrenal gland: WHO updates and clinical implications

Adrenokortikal adenomda myelolipomatöz değişiklikler

The diagnosis and treatment of primary adrenal lipomatous tumors in Chinese patients: a 31-year follow-up study

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