Non-Functioning Retroperitoneal Paraganglioma

Law, Nicholas; Alfano, Luigi

doi:10.1177/014107688708000416

Cited by 11 publications

(6 citation statements)

References 4 publications

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“…Patients with non-functioning retroperitoneal paragangliomas are usually asymptomatic until the tumour reaches sufficient size to produce symptoms of compression on adjacent organs. Typical symptoms include abdominal pain in 50% of cases as it was the case in our patient, nausea, vomiting, abdominal distension and weight loss [9]. Patients with functional paragangliomas undergo paroxysmal episodic hypertension, as well as palpitations, headache and profuse sweating [10,11].…”

Section: Discussionsupporting

confidence: 52%

Retroperitoneal Non-functioning Paraganglioma: A Case Report

Limaïem¹,

Bouraoui²,

Bouslama³

et al. 2013

J Interdiscipl Histopathol

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Retroperitoneal paragangliomas are relatively rare endocrine tumours derived from the extra-adrenal paraganglia of the autonomic nervous system. They can be functional when they secrete catecholamines or non-functional. The diagnosis of a paraganglioma is infrequently made preoperatively unless the tumour is functional. In this paper, the authors report a new case of non-functional paraganglioma. A 54-year-old woman with a past medical history of viral hepatitis, presented with vague abdominal pain of five years' duration. On examination, no abdominal mass was palpable and her blood pressure was 100/60 mm Hg. Abdominal computed tomography scan demonstrated a well-defined hypervascular retroperitoneal mass of heterogeneous density in the left para-aortic region measuring 3cm in diameter. As paraganglioma was suspected preoperatively, serum and urine cathecholamine levels were performed and were within normal range. Complete surgical excision of this mass was performed. Histological examination of the surgical specimen coupled with immunohistochemical study was consistent with the diagnosis of pararganglioma. Retroperitoneal paragangliomas are most commonly benign with good prognosis, but can be locally invasive and metastasize as well. The possibility for malignant transformation of paragangliomas makes surgical excision the treatment of choice. [J Interdiscipl Histopathol 2013; 1(3.000): 168-171

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Section: Discussionsupporting

confidence: 52%

Retroperitoneal Non-functioning Paraganglioma: A Case Report

Limaïem¹,

Bouraoui²,

Bouslama³

et al. 2013

J Interdiscipl Histopathol

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“…Paragangliomas in the retroperitoneum most commonly arise in the adrenal medulla, but about 10% may occur in extramedullary locations, most commonly at paraaortic or paravertebral sites. 8,9 These tumors can be benign or malignant; recurrences and metastases several years after initial resection have been reported, 10,11 and a case has been reported with neurofibromatosis. 12 The patient presented here showed local recurrence 2 yr postoperatively.…”

Section: Discussionmentioning

confidence: 99%

Fine-needle aspiration cytology of malignant retroperitoneal paraganglioma

et al. 1998

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The cytologic findings in a fine‐needle aspiration sample are described from a large retroperitoneal mass in a 56‐yr‐old male. The aspiration was performed under CT guidance using a 22‐gauge needle, maintaining negative pressure. For cytologic study, on‐site smears were prepared and stained by the Papanicolaou method. Additionally, cytospin, filter preparations, cell blocks from the aspirate, histology, and electron microscopy of the tumor tissue were performed. Also, immunodiagnostic staining for neuron‐specific enolase (NSE), chromogranin, S‐100 protein, vimentin, HMB45, cytokeratin, and Grimelius preparation was performed on cytologic and histologic material. The cytologic material was characterized by cords, suggestive acinar structures, and small follicle‐like clusters of cells, while cell blocks from the aspirate showed oval or spindle‐shaped nuclei with a somewhat fasciculated appearance. However, sections from the tumor tissue showed an organoid “zellballen” pattern. The nuclei were round, oval, spindly, and epithelioid, with moderate to scanty cytoplasm, smooth nuclear membranes, fine, evenly dispersed chromatin, slight hyperchromasia, and mild pleomorphism. No intranuclear vacuoles were seen. Positive immunohistochemical staining for NSE, chromogranin, and Grimelius preparation was noted in the tumor cells, while staining for vimentin, HMB45, and cytokeratin was negative. Electron microscopy of the tumor tissue revealed the presence of variable numbers of round, membrane‐bound, electron‐dense neurosecretory granules. The cytohistologic and ultrastructural findings are presented, as well as the results of immunodiagnostic staining which helped in the diagnosis of retroperitoneal paraganglioma, an infrequently reported tumor. Diagn. Cytopathol. 1998;18:287–290. © 1998 Wiley‐Liss, Inc.

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“…Characteristic symptoms are sharp headaches, hypertension, palpitation and sweating. For those patients with nonfunctional extraadrenal retroperitoneal paragangliomas, diagnosis usually depends on nonspecific factors related to the growth of a retroperitoneal mass [ 1 , 5 , 6 ]. The lumbar pain is one of the suggesting signals.…”

Section: Discussionmentioning

confidence: 99%

Renal hilar pheochromocytoma: a case report

Ahallal

Tazi

Elfatemi

et al. 2009

Cases J

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Paraganglioma is a rare tumor arising from undifferentiated cells of the primitive neural crest. These tumors are most commonly found in the adrenal gland, other localisations are also possible. A 58-year-old woman who presented with history of left lumbar pain, headache, hypertension, palpitation and sweating was found to have a secreting left renal hilar pheochromocytoma. Radical excision of the tumor was therefore undertaken and her hypertension was controlled. From the case report and literature review, the authors suggest a diagnostic and therapeutic strategy for the management of ectopic localization of pheochromocytoma.

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Non-Functioning Retroperitoneal Paraganglioma

Cited by 11 publications

References 4 publications

Retroperitoneal Non-functioning Paraganglioma: A Case Report

Retroperitoneal Non-functioning Paraganglioma: A Case Report

Fine-needle aspiration cytology of malignant retroperitoneal paraganglioma

Renal hilar pheochromocytoma: a case report

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