Non-gestational choriocarcinoma as a cause of heavy menstrual bleeding-potential: Primary care detection

Abstract

Choriocarcinoma is a malignant trophoblastic disease. It can be divided into gestational and non-gestational type. Gestational choriocarcinoma consists of less than 1% of total endometrial malignancy, and usually is diagnosed via histopathological examination preceding a suspected molar pregnancy. In contrast to gestational choriocarcinoma, only a few cases of primary non-gestational choriocarcinoma were reported in literature reviews. The reported locations for primary non-gestational choriocarcinoma were ovarian and uterine cervix. Due to its low incidence, this disease is often overlooked leading, to delayed diagnosis. In primary care practice, heavy menstrual bleeding is a common presentation. Further evaluations, such as full blood count, ultrasound pelvis or hysteroscopy are usually required. We would like to report a case of potentially earlier detection of non-gestational choriocarcinoma in a 52 years old lady who was presented with heavy menstrual bleeding for a duration of one year. Her symptom persisted despite receiving medical treatment in a few local primary care clinics. She was admitted to a tertiary hospital for symptomatic anaemia which required blood transfusion. Further evaluations, (i.e., laboratory tests, ultrasound, Computed Topography (CT) scan, bone scan, hysteroscopy and laparotomy total abdominal hysterectomy and bilateral salphingo-oophorectomy (TAHBSO) and histological examination) concluded a diagnosis of primary non-gestational choriocarcinoma of fundal uterus with lung metastasis.
 Bangladesh Journal of Medical Science Vol.19(4) 2020 p.755-759

Abnormal uterine bleeding in women of reproductive age: PALM-COEIN causes

“…Among the non-structural components of the causes of AUB in women of the reproductive period the most spread is ovulatory dysfunction -37.6 % 10 . But nevertheless, one should not forget about the infrequent causes of AUB, for example, chorionic carcinoma11 and cavernous haemangioma12 .The results of our study are consistent with data from other scientists. Thus we found that the rate of PALMcauses is 66.90 %, COEIN -33.10 %.…”

All-Trans Retinoic Acid Reduces Matrix Metalloproteinase-2 and Increases E-Cadherin Levels in BeWo Choriocarcinoma Cells

“…Choriocarcinoma is a malignant tumor resulting from the abnormal proliferation of trophoblasts. 1 The placenta of patients with choriocarcinoma is characterized by hemorrhage, necrosis, the absence of chorionic villi, and high metastatic potential.…”