Over one million children are born with congenital heart disease (CHD) each year around the world (1). Approximately one in two children with CHD will require surgical or interventional care at least once in their lifetime (2), whereas one in five will need an intervention to survive to their first birthday (3). In addition, rheumatic heart disease (RHD) represents the most common acquired cardiovascular disease among children and adolescents (4). RHD is a disease of poverty largely eradicated in high-income countries, yet it continues to affect dozens of millions of people across low-and middle-income countries (LMICs) (4,5). Despite this considerable burden of cardiac surgical disease, over 90% of children in LMICs no access to cardiovascular care (6,7) resulting in more than 90% of deaths and disability-adjusted life-years (DALYs) in children to be "excess" (8).The current special series on "Addressing Global Disparities in Pediatric and Congenital Cardiac Care" provides a detailed overview of cardiovascular care for children living with cardiovascular diseases worldwide, with a particular emphasis on variable-resource contexts, where the disparities are greatest. Articles are briefly introduced in this editorial and include: (I) Addressing Global Disparities in Pediatric and Congenital Cardiac Care: introduction to the special series. (II) Narrative review in pediatric and congenital heart surgery in sub-Saharan Africa: challenges and opportunities in a new era. (III) "Regale una Vida" a successful social program for underprivileged children with congenital heart disease in a middle-income country. (IV) Pediatric cardiac NGOs: collaboration and coordination. (V) Fostering a sustainable pediatric cardiac workforce in the developing world during the current coronavirus disease 2019 (COVID-19) pandemic. (VI) Pediatric Cardiac Development Assistance in Conflict Zones. (VII) The road to regionalization in congenital heart surgery: a narrative review. (VIII) Generating political support for cardiac surgical care in resource-limited contexts: experience from Nepal.(IX) Ethics of resource allocation to congenital heart surgery in variable-resource contexts. This special series may expand upon and accelerate the contemporary global health discourse, which largely lacks the integration of pediatric and congenital cardiovascular care. Without an urgent recognition of the importance of pediatric and congenital cardiovascular care, the 2030 United Nations Sustainable Development Goal Agenda cannot and will not be attained (9).
Global disparitiesRecent data confirm great disparities in the number of pediatric cardiac surgeons per million population. In high-income countries, there are approximately 9.51 pediatric cardiac surgeons per million under-15 population compared to only 0.07 per million in low-income countries (10). However, the number of pediatric cardiac surgeons managing neonates and infants with CHD is assumed to be far lower, although not exactly quantified (11). As such, Murala et al. (12). discuss opportunit...