Non-HDL-C/HDL-C ratio is associated with carotid plaque stability in general population: A cross-sectional study

Wang, Anran; Li, Yapeng; Zhou, Lue; Li, Kai; Li, Shaohua; Zong, Ce; Song, Bo; Gao, Yuan; Li, Yusheng; Tian, Chuansheng; Xing, Yurong; Xu, Yuming; Wang, Longde

doi:10.3389/fneur.2022.875134

Cited by 25 publications

(18 citation statements)

References 45 publications

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“…Recently, there has been a growing interest in the role of other atherogenic lipoproteins in the development of atherosclerosis and its associated clinical outcomes 21–23 . A study involving 27 436 urban workers in China found a significant association between the non‐HDL‐C/HDL‐C ratio and the stability of carotid plaque 24 . Likewise, a study of 426 patients with first‐onset non‐ST‐segment elevation acute myocardial infarction (NSTEMI) indicated that the non‐HDL‐C/HDL‐C ratio is significantly associated with severe coronary lesions and functions as an independent predictor of cardiovascular outcomes among NSTEMI patients 25 .…”

Section: Discussionmentioning

confidence: 99%

“… 21 , 22 , 23 A study involving 27 436 urban workers in China found a significant association between the non‐HDL‐C/HDL‐C ratio and the stability of carotid plaque. 24 Likewise, a study of 426 patients with first‐onset non‐ST‐segment elevation acute myocardial infarction (NSTEMI) indicated that the non‐HDL‐C/HDL‐C ratio is significantly associated with severe coronary lesions and functions as an independent predictor of cardiovascular outcomes among NSTEMI patients. 25 Furthermore, an analysis of 46 786 patients with type 2 diabetes showed that lower levels of non‐HDL‐C/HDL‐C are more effective risk markers for ASCVD compared to LDL‐C levels below 3 mmol/L.…”

Section: Discussionmentioning

confidence: 99%

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A higher non‐HDL‐C/HDL‐C ratio was associated with an increased risk of progression of nonculprit coronary lesion in patients with acute coronary syndrome undergoing percutaneous coronary intervention

Liu,

Zhao,

Zhang

et al. 2024

Clinical Cardiology

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BackgroundThe ratio of nonhigh‐density lipoprotein cholesterol (non‐HDL‐C) to high‐density lipoprotein cholesterol (HDL‐C) has been shown associated with various metabolic diseases and atherosclerosis in primary prevention. However, there is limited evidence on the relationship between the non‐HDL‐C/HDL‐C ratio and progression of nonculprit coronary lesion (NCCL) after percutaneous coronary intervention (PCI).HypothesisOur study aimed to investigate the potential association between the non‐HDL‐C/HDL‐C ratio and NCCL progression in patients with acute coronary syndrome (ACS) undergoing PCI.MethodsWe conducted a retrospective analysis of ACS patients who underwent coronary angiography twice at a single center from 2016 to 2022. Lipid measurements, demographic, clinical, and other laboratory data were collected from electronic medical records. NCCLs were evaluated using quantitative coronary angiography. The primary outcome was the progression of NCCL. Patients were categorized based on NCCL progression and tertiles of the non‐HDL‐C/HDL‐C ratio. Associations were analyzed using univariate and multivariate logistic regression analysis.ResultsThe study included 329 ACS patients who underwent PCI, with a median follow‐up angiography of 1.09 years. We found NCCL progression in 95 (28.9%) patients with acceptable low‐density lipoprotein cholesterol control (median: 1.81 mmol/L). Patients in the top tertile of the non‐HDL‐C/HDL‐C ratio had a higher risk of NCCL progression. After adjusting for potential confounding factors, the non‐HDL‐C/HDL‐C ratio remained a significant predictor for NCCL progression (adjusted odds ratio: 1.45; 95% confidence interval: 1.14–1.86; p < 0.05).ConclusionsThe non‐HDL‐C/HDL‐C ratio predicts NCCL progression in ACS patients following PCI, providing a valuable tool for risk assessment and enhancing secondary prevention of atherosclerotic cardiovascular disease.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

A higher non‐HDL‐C/HDL‐C ratio was associated with an increased risk of progression of nonculprit coronary lesion in patients with acute coronary syndrome undergoing percutaneous coronary intervention

Liu,

Zhao,

Zhang

et al. 2024

Clinical Cardiology

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“…This correlation was found to be particularly significant among women ( 13 ). Additionally, a study based on an urban Chinese cohort revealed that the non-HDL-C/HDL-C ratio was notably linked with the stability of carotid plaques, suggesting that it could serve as a valuable marker for the early detection of carotid plaques at elevated risk ( 47 ). Given that carotid atherosclerosis plays a significant role in stroke development ( 48 ), it is noteworthy that a recent Chinese cohort study discovered a positive association between the non-HDL-c/HDL-c ratio and stroke.…”

Section: Discussionmentioning

confidence: 99%

The non-linear link between non-high-density lipoprotein to high-density lipoprotein ratio and the risk of stroke in middle-aged and older adults in Chinese: a prospective cohort study from the China health and retirement longitudinal study

Wang,

Han,

Cao

et al. 2024

Front. Endocrinol.

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ObjectiveThis study aims to assess the association between the non-HDL-c/HDL-c ratio and stroke risk among middle-aged and older adults participating in the China Health and Retirement Longitudinal Study (CHARLS).MethodsThis study conducted a prospective cohort analysis, enrolling a total of 10,183 participants who met the designated criteria from CHARLS between 2011 and 2012. We then used the Cox proportional-hazards regression model to explore the relationship between baseline non-HDL-c/HDL-c ratio and stroke risk. Using a Cox proportional hazards regression with cubic spline function, we were able to identify the non-linear relationship between the non-HDL-c/HDL-c ratio and stroke occurrence. A series of sensitivity analyses were also carried out.ResultsThe average age of the participants included in this study was 59.16 ± 9.35 years, and 4,735 individuals (46.68%) were male. Over a median follow-up period of 7.0 years, a total of 1,191 people (11.70%) experienced a stroke. Using a Cox proportional hazards regression model that was fully adjusted, we found no statistically significant correlation between the non-HDL-c/HDL-c ratio and the risk of stroke (HR=1.022; 95% CI 0.964, 1.083). Nevertheless, we did observe a non-linear relationship and saturation effect between the non-HDL-c/HDL-c ratio and stroke. Employing a two-piece Cox proportional hazards regression model and a recursive algorithm, we determined an inflection point of 2.685 for the non-HDL-c/HDL-c ratio. In instances where the non-HDL-c/HDL-c ratio fell below 2.685, for every 1-unit decrease in the non-HDL-c/HDL-c ratio, the likelihood of stroke decreased by 21.4% (HR=1.214, 95% CI: 1.039-1.418). In contrast, when the non-HDL-c/HDL-c ratio exceeded 2.685, there was no statistically significant change in the risk of stroke for each unit decrease in the non-HDL-c/HDL-c ratio (HR: 0.967, 95% CI: 0.897-1.042). The consistency of these findings across multiple sensitivity analyses suggests their robustness.ConclusionThis study unveils a non-linear relationship between the non-HDL-c/HDL-c ratio and stroke risk in middle-aged and older adults in China. Specifically, when the non-HDL-c/HDL-c ratio was below 2.685, a significant and clearly positive association with stroke risk was observed. Additionally, maintaining the non-HDL-c/HDL-c ratio below 2.685 could potentially lead to a substantial reduction in the risk of stroke.

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“…As a signi cant lipid marker for plaque prevention as well as a novel risk factor for the development of atherosclerotic plaque, NHHR is considered an emerging lipid biomarker for atherosclerosis [11,29].…”

Section: Discussionmentioning

confidence: 99%

“…The focus of this study was on NHHR, which was identi ed as the key variable. Calculation of NHHR employed methodologies derived from previous research [11]. Total cholesterol (TC) and HDL cholesterol (HDL-C) levels were evaluated using enzymatic assays conducted on automated biochemistry analyzers [12].…”

Section: Exposure De Nitionmentioning

confidence: 99%

The association between non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) and Prostate specific antigen (PSA): a cross-sectional study

Huang,

Lin,

Xiao

et al. 2024

Preprint

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Background There is mounting evidence that prostate-specific antigen (PSA) levels can be influenced by lipid metabolism. However, there is still no clear relationship between PSA levels and the ratio of non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol (NHHR). This study's goal is to evaluate the association between PSA and NHHR by using data from the National Health and Nutrition Examination Survey (NHANES). Methods We used data from the NHANES from 2003 to 2010 to examine the connection between PSA and NHHR. Out of 41,156 participants, 6,015 met our inclusion criteria. Serum triglycerides served as our independent variable, while PSA was the dependent variable. Results The study's participants were 59.7 years old on average, with a standard deviation of 12.7 years. After controlling for potential confounding variables, a one-unit increment in NHHR was associated with a decrease of 0.15 ng/mL in PSA levels, with a 95% confidence interval ranging from − 0.22 to -0.08, indicating a statistically significant inverse relationship. Moreover, a restricted cubic spline analysis further corroborated the presence of a statistically significant, largely inverse association between NHHR and PSA concentrations. Conclusions Among American males, NHHR is inversely correlated with PSA. This negative correlation might make it challenging for men with higher triglycerides to detect asymptomatic prostate cancer and achieve early diagnosis.

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Non-HDL-C/HDL-C ratio is associated with carotid plaque stability in general population: A cross-sectional study

Abstract: and Wang L ( ) Non-HDL-C/HDL-C ratio is associated with carotid plaque stability in general population: A cross-sectional study.

Cited by 25 publications

References 45 publications

A higher non‐HDL‐C/HDL‐C ratio was associated with an increased risk of progression of nonculprit coronary lesion in patients with acute coronary syndrome undergoing percutaneous coronary intervention

A higher non‐HDL‐C/HDL‐C ratio was associated with an increased risk of progression of nonculprit coronary lesion in patients with acute coronary syndrome undergoing percutaneous coronary intervention

The non-linear link between non-high-density lipoprotein to high-density lipoprotein ratio and the risk of stroke in middle-aged and older adults in Chinese: a prospective cohort study from the China health and retirement longitudinal study

The association between non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) and Prostate specific antigen (PSA): a cross-sectional study

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