Non–Heart-Beating Donor, Renewal of an Old Procedure: A Belgian Experience

Deynse, D. Van; Dumont, V.; Lecomte, Christel; Squifflet, Jean‐Paul; Mourad, Michel; Verschuren, Franck; Dufrane, Denis; Hantson, Philippe; Malaise, Jacques

doi:10.1016/j.transproceed.2005.05.033

Cited by 5 publications

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“…Some laboratory studies support a controversial 60 min WIT limitation [14][15][16] , but different experimental animals, warm ischemia models and experiment conditions may cause arguments about the WIT limitation. The argument about the WIT limitation has led to a worldwide investigation on warm ischemiareperfusion injury [17,18] . In the present study, we observed the changes of histological structure and ultrastructure of liver grafts during different WIT.…”

Section: Discussionmentioning

confidence: 99%

Dynamical changing patterns of histological structure and ultrastructure of liver graft undergoing warm ischemia injury from non-heart-beating donor in rats

Ma¹,

Wang²,

Wu³

et al. 2006

WJG

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AIM:To investigate the histological and ultra-structural characteristics of liver graft during different of warm ischemia time (WIT) in rats and to predict the maximum limitation of liver graft to warm ischemia. METHODS:The rats were randomized into 7 groups undergoing warm ischemia injury for 0, 10, 15, 20, 30, 45 and 60 min, respectively. All specimens having undergone warm ischemia injury were investigated dynamically by light and electron microscopy, and histochemistry staining. After orthotopic liver transplantation (OLT)，the recovery of morphology of liver grafts after 6, 24 and 48 h was observed. RESULTS:The donor liver from non-heart-beating donors (NHBD) underwent ischemia injury both in the warm ischemia period and in the reperfusion period. Morphological changes were positively related to warm ischemia injury in a time-dependent manner during the reperfusion period. The results demonstrated that different degrees of histocyte degeneration were observed when WIT was within 30 min, and became more severe with the prolongation of WIT, no obvious hepatocyte necrosis was noted in any specimen. In the group undergoing warm ischemia injury for 45 min, small focal necrosis occurred in the central area of hepatic lobule first. In the group undergoing warm ischemia injury for 60 min, patchy or diffused necrosis was observed and the area was gradually extended, while hepatic sinusoid endothelial cells were obviously swollen. Hepatic sinusoid was obstructed and microcirculation was in disorder. CONCLUSION:The rat liver graft undergoing warm ischemia injury is in the reversible stage when the WIT is within 30 min. The 45 min WIT may be a critical point of rat liver graft to endure warm ischemia injury. When the WIT is over 60 min, the damage is irreversible.

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Section: Discussionmentioning

confidence: 99%

Dynamical changing patterns of histological structure and ultrastructure of liver graft undergoing warm ischemia injury from non-heart-beating donor in rats

Ma¹,

Wang²,

Wu³

et al. 2006

WJG

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Legal Considerations on the Determination and Certification of Human Death

Machado

Brain Death

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In defense of the reverence of all life: Heideggerean dissolution of the ethical challenges of organ donation after circulatory determination of death

Isch

2007

Med Health Care and Philos

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During the past 50 years since the first successful organ transplant, waiting lists of potential organ recipients have expanded exponentially as supply and demand have been on a collision course. The recovery of organs from patients with circulatory determination of death is one of several effective alternative approaches recommended to reduce the supply-and-demand gap. However, renewed debate ensues regarding the ethical management of the overarching risks, pressures, challenges and conflicts of interest inherent in organ retrieval after circulatory determination of death. In this article, the author claims that through the engagement of a Heideggerean existential phenomenological and hermeneutic framework what are perceived as ethical problems dissolve, including collapse of commitment to the dead donor rule. The author argues for a revisioned socially constructed conceptual and philosophical responsibility of humankind to recognize the limits of bodily finitude, to responsibly use the capacity of the transplantable organs, and to grant enhanced or renewed existence to one with diminished or life-limited capacity; thereby making the locus of ethical concern the donor-recipient as unitary ''life.'' What ethically matters in the life-cycle (life-world) of donor-recipient is the viability of the organs transplanted; thereby granting reverence to all life.

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Non–Heart-Beating Donor, Renewal of an Old Procedure: A Belgian Experience

Cited by 5 publications

References 0 publications

Dynamical changing patterns of histological structure and ultrastructure of liver graft undergoing warm ischemia injury from non-heart-beating donor in rats

Dynamical changing patterns of histological structure and ultrastructure of liver graft undergoing warm ischemia injury from non-heart-beating donor in rats

Legal Considerations on the Determination and Certification of Human Death

In defense of the reverence of all life: Heideggerean dissolution of the ethical challenges of organ donation after circulatory determination of death

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