Non-heart-beating donors

Raemdonck, Dirk Van; Rega, Filip; Neyrinck, Arne; Jannis, Nicole; Verleden, Geert M.; Lerut, Toni

doi:10.1053/j.semtcvs.2004.09.014

Cited by 101 publications

(79 citation statements)

References 115 publications

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“…His group showed that lung cells remain viable for a certain period after circulatory arrest (Alessandrini et al 1994;D'Armini et al 1994). The lung is the sole solid organ that is not dependent on perfusion for aerobic metabolism but rather uses a mechanism of passive diffusion through the alveoli for substrate delivery (Keshavjee et al 1992;Date et al 1993;Egan 2004;Van Raemdonck et al 2004).…”

Section: Donation After Cardiac Deathmentioning

confidence: 99%

Overview of Clinical Lung Transplantation

Yeung

Keshavjee

2014

Cold Spring Harbor Perspectives in Medicine

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Since the first successful lung transplant 30 years ago, lung transplantation has rapidly become an established standard of care to treat end-stage lung disease in selected patients. Advances in lung preservation, surgical technique, and immunosuppression regimens have resulted in the routine performance of lung transplantation around the world for an increasing number of patients, with wider indications. Despite this, donor shortages and chronic lung allograft dysfunction continue to prevent lung transplantation from reaching its full potential. With research into the underlying mechanisms of acute and chronic lung graft dysfunction and advances in personalized diagnostic and therapeutic approaches to both the donor lung and the lung transplant recipient, there is increasing confidence that we will improve short-and long-term outcomes in the near future.

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Section: Donation After Cardiac Deathmentioning

confidence: 99%

Overview of Clinical Lung Transplantation

Yeung

Keshavjee

2014

Cold Spring Harbor Perspectives in Medicine

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“…The exact length of the postmortem WIT is often not known. As organ function in these donors cannot be assessed before death, viability should be properly evaluated afterwards before organ transplantation to reduce the risk of primary nonfunction (1,6,8).…”

Section: Definition and Categoriesmentioning

confidence: 99%

“…The warm ischemic period of the graft is limited to 10 to 15 minutes after death certification if withdrawal of life support is executed in the operating room. Lungs can be inspected in situ, and preserved in the standard way (1). Recently, modified Maastricht classification of DCD has been published ( Table 2) (3).…”

Section: Definition and Categoriesmentioning

confidence: 99%

“…The percentage of lung retrieval rate is lower when compared to other solid organs. Brain death itself leads to hemodynamic, metabolic and neuroendocrine abnormalities resulting in so-called neurogenic pulmonary edema (1,2). This initial insult in combination with possible airway aspiration, respiratory tract infection, atelectasis and pulmonary contusion, may all contribute to lung damage before harvest (1).…”

Section: Introductionmentioning

confidence: 99%

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Donors after cardiocirculatory death and lung transplantation

İnci

2017

J. Thorac. Dis.

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Abstract:The number of patients actively awaiting lung transplantation (LTx) is more than the number of suitable donor lungs. The percentage of lung retrieval rate is lower when compared to other solid organs.The use of lungs from donation after cardiocirculatory death (DCD) donors is one of the options to avoid organ shortage in LTx. After extensive experimental research, clinical application of DCD donation is becoming wider. The results from most of the centers show at least equal survival rate compared to donors from brain death. This review paper will summarize experimental background and clinical experience from DCD donors.

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“…On the other hand, obtaining a gas exchange is possible up to two hours after cardiac arrest, without need of lung circulation, especially if oxygen has been blown into alveoli [15]. This time frame can be increased up to 4 hours after cadaver heparinization and up to 12-24 hours if lungs are cooled down (15 to 20°C) [16]. Even though other countries started considering intra-hospital or controlled donors earlier, Spain was pioneer at considering outpatient donors.…”

Section: Introductionmentioning

confidence: 99%

Pulmonary Function Assessment Method with Type II Non-heart Beating Donors in Spain is Valid

Meneses¹

2013

J Transplant Technol Res

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Lung transplantation unit from Hospital 12 de Octubre began its work in October 2008. In the last five years, 80 lung transplants have been performed with a hospital mortality rate of 6.5% and a five years survival of 79.7%. As a result of the need of obtaining a greater number of donors, and encouraged by the outpatient non heart beating donors program within our hospital, we considered the possibility of assessing these donors lung grafts. We have followed the methodology designed and set off with good results by other hospitals in the area of Madrid. Nevertheless some changes have been included such as Bithermical multiorgan preservation, where abdominal organs are preserved in normothermia and thoracic ones in hypothermia. However, this methodology has not been scientifically proven. We have reproduced in a laboratory lung function assessment manoeuvres of pulmonary grafts from non heart beating donors. Then we have compared the correlation with the lung function assessment before cardiac arrest, applying the procedure on 40 pigs. Outcomes are promising.

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Non-heart-beating donors

Cited by 101 publications

References 115 publications

Overview of Clinical Lung Transplantation

Overview of Clinical Lung Transplantation

Donors after cardiocirculatory death and lung transplantation

Pulmonary Function Assessment Method with Type II Non-heart Beating Donors in Spain is Valid

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