Non Heart-Beating Donors in England

Chaib, Eleazar

doi:10.1590/s1807-59322008000100020

Cited by 16 publications

(10 citation statements)

References 87 publications

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“…Our primary non function rate was 3.2%, similar to that found by other teams [3,4,27], including cohorts of 'controlled donors' [2]. The delayed graft function rate for NHBD transplants is higher than in heart beating donor (HBD) kidneys, and is more frequent in uncontrolled donors [21] than in controlled donors as illustrated by a greater incidence of acute tubular necrosis [29].…”

Section: Discussionsupporting

confidence: 82%

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Kidney retrieval after sudden out of hospital refractory cardiac arrest: a cohort of uncontrolled non heart beating donors

et al. 2009

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Introduction To counter the shortage of kidney grafts in France, a non heart beating donor (NHBD) program has recently been implemented. The aim of this study was to describe this pilot program for kidney retrieval from "uncontrolled" NHBD meaning those for whom attempts of resuscitation after a witnessed outof-hospital cardiac arrest (CA) have failed (Maastricht 1 and 2), in a centre previously trained for retrieval from brain dead donors.

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Section: Discussionsupporting

confidence: 82%

“…The discard rate for uncontrolled donors in England was estimated to range between 50 and 65% [27]. Our final transplantation rate was 25% (63 potential NHBD/31 renal grafts).…”

Section: Discussionmentioning

confidence: 99%

Kidney retrieval after sudden out of hospital refractory cardiac arrest: a cohort of uncontrolled non heart beating donors

et al. 2009

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“…While the use of kidneys and livers from DCD donors is increasing [9,10] , the use of DCD pancreata is still low (UNOS). DCD is not a novel concept.…”

Section: Discussionmentioning

confidence: 99%

A mathematical model for shortening waiting time in pancreas-kidney transplantation

Chaib¹,

Ribeiro²,

Santos³

et al. 2011

WJGS

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AIM:To simulate a hypothetical increase of 50% in the number of pancreas-kidney (PK) transplantations using less-than-ideal donors by a mathematical model. METHODS:We projected the size of the waiting list by taking into account the incidence of new patients per year, the number of PK transplantations carried out in the year and the number of patients who died on the waiting list or were removed from the list for other reasons. These variables were treated using a model developed elsewhere. RESULTS:We found that the waiting list demand will meet the number of PK transplantation by the year 2022. CONCLUSION:In future years, it is perfectly possible to minimize the waiting list time for pancreas transplantation through expansion of the donor pool using lessthan-ideal donors.

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“…Since 1968 and until now, procurement was limited to heart beating brain dead donors. The results of kidneys transplanted from non heart beating donors have significantly improved and nowadays are comparable to those of kidney transplantations from brain dead donors, thanks to a greater selection of donors and recipients and to improved prevention of cold and warm ischemia times as well as to several major therapeutic innovations (Alonso et al, 2005;Lee et al, 2005;Gagandeep et al, 2006;Kokkinos et al, 2007;Chaib, 2008). Procurement of non heart beating donors is therefore being reconsidered under considerations of feasibility, results and ethical and legal consequences.…”

Section: Legislationmentioning

confidence: 99%

Organ donation in France: legislation, epidemiology and ethical comments

et al. 2009

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The Bioethics Laws revised in 2004 have defined rules concerning organ donation and transplantation. They have also permitted the creation of the French Biomedicine Agency which guarantees the right of enforcement. In France there are three situations in which organs may be harvested: from cadaveric donors, from living donors and, since 2005, from non heart beating donors. Organ harvesting from cadaveric donors is permissible if the deceased did not make known his refusal during his lifetime (this may be recorded in the national registry set up for this purpose). The rule of presumed consent also applies in the case of organs taken after cardiac arrest. With regard to organ harvesting from living persons, a panel of experts is required to give approval. The recipient's spouse, brothers or sisters, sons or daughters, grandparents, uncles or aunts and first cousins may be authorised to donate organs, as well as the spouse of the recipient's father or mother. The donor may be any person who provides proof of having lived with the recipient for at least two years. Some ethical questions will need to be resolved; for example the relevance of maintaining the EEG for brain death diagnosis, enforcement of the law on presumed consent, the real nature of the will of living donors and the definition of death.

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Non Heart-Beating Donors in England

Cited by 16 publications

References 87 publications

Kidney retrieval after sudden out of hospital refractory cardiac arrest: a cohort of uncontrolled non heart beating donors

Kidney retrieval after sudden out of hospital refractory cardiac arrest: a cohort of uncontrolled non heart beating donors

A mathematical model for shortening waiting time in pancreas-kidney transplantation

Organ donation in France: legislation, epidemiology and ethical comments

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