Non-high-density lipoprotein cholesterol and the development of coronary heart disease and stroke subtypes in a general Japanese population: The Hisayama Study

Imamura, Tsuyoshi; Doi, Yasufumi; Ninomiya, Toshiharu; Hata, Jun; Nagata, Michio; Ikeda, Fumie; Mukai, Naoko; Hirakawa, Yoichiro; Yoshida, Daigo; Fukuhara, Mikio; Kitazono, Takanari; Kiyohara, Yutaka

doi:10.1016/j.atherosclerosis.2014.01.005

Cited by 38 publications

(36 citation statements)

References 18 publications

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“…The Hisayama Study, including 2452 community-dwelling Japanese subjects aged >40 years, evaluated the association between non-HDLC levels and the risk of type-specific cardiovascular disease in the general Japanese population. After adjustment for confounders, the associations remained significant for atherothrombotic infarction (adjusted hazard ratio (HR) for a 1 standard deviation of non-HDLC concentrations = 1.39, 95% CI = 1.09 to 1.79)16. A study in chinese, including 27,020 participants aged 35 to74 years found that an increase of 30 mg/dl in non-HDLC level would correspond to 12% increase in risk of stroke17.…”

Section: Discussionmentioning

confidence: 99%

Non-High-Density Lipoprotein Cholesterol Levels on the Risk of Asymptomatic Intracranial Arterial Stenosis: A Result from the APAC Study

Wang

et al. 2016

Sci Rep

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Intracranial arterial stenosis (ICAS) is an important cause of ischemic stroke and transient ischemic attack (TIA), and the correlation between the plasma non-high density cholesterol (non-HDLC) levels and ICAS, especially asymptomatic ICAS (AICAS) is not clear. The Asymptomatic Polyvascular Abnormalities Community(APAC) study is a community-based, prospective, long-term follow-up observational study. 3387 participants were enrolled in this study. The diagnosis of AICAS was made by transcranial Doppler ultrasonography. The participants were then divided into 3 groups based on their non-HDLC levels. The cox regression was used to analyze the correlation between the non-HDLC level and the incidence of AICAS.9.98% of the participants were diagnosed with AICAS during 2 years following up. Multivariate analysis showed that non-HDL-C is an independent indicator for the incidence of AICAS (HR = 1.22, 95%CI: 1.06–1.40), The incidence of AICAS gradually increase with the increasing non-HDLC level. Compared with subgroup(non-HDLC < 3.4 mmol/l), incidence of AICAS was significantly higher in the subgroups(non-HDLC 3.4–4.1 mmol/l and non-HDLC ≥ 4.1 mmol/l) after adjustment for the confounding factors (HR = 1.32, 95%CI:1.02–1.73; HR = 1.46, 95%CI: 1.10–1.94, respectively). In conclusions, our findings suggest that elevated non-HDLC levels a significant risk factor for the development of AICAS in the APAC study.

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Section: Discussionmentioning

confidence: 99%

Non-High-Density Lipoprotein Cholesterol Levels on the Risk of Asymptomatic Intracranial Arterial Stenosis: A Result from the APAC Study

Wang

et al. 2016

Sci Rep

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“…The non–HDL-C level can represent cholesterol levels in atherogenic lipoproteins, and it may be a useful lipid marker for predicting the onset of future cardiovascular-related events in daily clinical practice. Japanese epidemiological data regarding the association between non–HDL-C and fatal and/or nonfatal CVD have been accumulated, such as the Hisayama study, Suita study, Ibaraki Prefectural Health study, NIPPON DATA, and pooled analyses 42–46. Apolipoprotein B represents all atherogenic apoB-containing lipoproteins, including chylomicrons, chylomicron remnants, VLDL, IDL, LDL, and Lp(a) particles containing one molecule of apoB, and so on, and these lipoproteins have been identified as possible predictors of CAD; however, limited research has been performed regarding these new risk markers, such as the apoB/apoA-I ratio, in Japan 47…”

Section: Non–hdl-c and Beyond Low-density Lipoprotein Cholesterolmentioning

confidence: 99%

Atherosclerotic Cardiovascular Risk in Japan

Nojiri

Daida

2017

Jpn Clin Med

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Increased global mortality is associated with atherosclerosis, which appears to be independent of race. Cardiovascular disease is one of the leading causes of mortality and morbidity in Japan. Atherosclerosis, an inflammatory disease characterized by abnormal lipid accumulation and inflammation in the arterial wall, is the main underlying cause of cardiovascular disease. Numerous cardiovascular risk scores have been developed and are used to prioritize patients’ treatment needs. The predictive performance of risk scores established in Western nations needs to be examined in Japanese populations. For secondary prevention, it is imperative to control hypertension, hyperlipidemia, diabetes mellitus, smoking, and local interventions. In this review, we present a historical overview of atherosclerotic risk research and the risk factors for atherosclerosis in Japan and compare the situation in Japan with that in Western nations. In addition, we discuss relevant cardiovascular risk assessment tools in the context of clinical practice in Japan.

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“…CHD was defined as acute myocardial infarction, silent myocardial infarction, sudden cardiac death within 1 h of the onset of acute illness, or included those who had undergone coronary intervention (coronary artery bypass surgery or angioplasty). Acute myocardial infarction was diagnosed using the criteria described elsewhere 29) . Stroke was defined as an acute onset of nonconvulsive and focal neurological deficit lasting for more than 24 h. All CVD events were adjudicated on the basis of physical examination, a review of all available clinical data, including medical records and brain imaging, and autopsy findings by a panel of the study members.…”

Section: Introductionmentioning

confidence: 99%

Serum Non-High-Density Lipoprotein Cholesterol and Risk of Cardiovascular Disease in Community Dwellers with Chronic Kidney Disease: the Hisayama Study

Usui

Nagata

Hata

et al. 2017

J Atheroscler Thromb

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Aim: It is not clear whether elevated serum non-high-density lipoprotein cholesterol (non-HDL-C) levels are a risk factor for cardiovascular disease (CVD) in subjects with chronic kidney disease (CKD) in the general population.Methods: A total of 2,630 community-dwelling Japanese subjects (1,107 men and 1,523 women) without history of CVD and aged ≥ 40 years were prospectively followed up for an average of 19 years, and the association between serum non-HDL-C levels and the incidence of type-specific CVD was estimated using a Cox proportional hazards model. CKD was defined as estimated glomerular filtration rate < 60 mL/min/1.73 m2 or proteinuria (≥ 1 + on dipstick).Results: At baseline, 357 subjects had CKD. During the follow up, 186 coronary heart disease (CHD) and 277 stroke events occurred. The age- and sex-adjusted incidence of CHD was significantly higher in subjects with higher non-HDL-C levels, both in those with and without CKD. In the CKD group, the risk of CHD was significantly higher in those with non-HDL-C levels of 150–189 mg/dL [adjusted hazard ratio (HR), 2.23; 95% confidence interval (CI), 1.04–4.77] and those with levels ≥ 190 mg/dL (adjusted HR, 3.20; 95% CI, 1.46–7.03) than in those with levels < 150 mg/dL. In the non-CKD group, the risk of CHD was significantly higher only in those with non-HDL-C levels ≥ 190 mg/dL (adjusted HR, 2.12; 95% CI, 1.33 –3.38). However, no such association was observed for the risk of stroke.Conclusions: Our findings suggest that higher serum non-HDL-C levels are associated with greater risk of CHD in subjects with and without CKD and that this association is greater in subjects with CKD than in those without CKD.

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Non-high-density lipoprotein cholesterol and the development of coronary heart disease and stroke subtypes in a general Japanese population: The Hisayama Study

Cited by 38 publications

References 18 publications

Non-High-Density Lipoprotein Cholesterol Levels on the Risk of Asymptomatic Intracranial Arterial Stenosis: A Result from the APAC Study

Non-High-Density Lipoprotein Cholesterol Levels on the Risk of Asymptomatic Intracranial Arterial Stenosis: A Result from the APAC Study

Atherosclerotic Cardiovascular Risk in Japan

Serum Non-High-Density Lipoprotein Cholesterol and Risk of Cardiovascular Disease in Community Dwellers with Chronic Kidney Disease: the Hisayama Study

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