Non‐high‐density lipoprotein cholesterol is more informative than traditional cholesterol indices in predicting diabetes risk for women with normal glucose tolerance

Liu, Lu; Qiu, Li Xin; Yuan, Zhongshang; Zhao, Meng; Zhang, Xu; Zhang, Haiqing; Zheng, Donghai; Xu, Jin; Gao, Ling; Guan, Qingbo; Zhao, Jiajun; Proud, Christopher G.; Wang, Xuemin; Hou, Xu

doi:10.1111/jdi.12837

Cited by 9 publications

(7 citation statements)

References 27 publications

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“…After administering UA for 15 weeks, the average body weight, liver weight, and epididymal and perirenal adipose contents significantly reduced in the UA (at 100 mg/kg) group by 22.7%, 28%, 27.2%, and 52.1% compared with the HFD group, respectively (all P < 0.05). Non‐HDL‐C is considered to be an important risk factor for predicting obesity‐related chronic diseases and is superior to low‐density lipoprotein cholesterol in disease assessment (Liu et al., 2018; Ramjee, Sperling, & Jacobson, 2011; Verbeek, Hovingh, & Boekholdt, 2015). Therefore, the serum levels of TC, TG, HDL‐C, and non‐HDL‐C and the TC and TG contents in liver tissue were tested to evaluate the lipid‐lowering effect of UA (Table 4).…”

Section: Resultsmentioning

confidence: 99%

Ursolic acid alleviates lipid accumulation by activating the AMPK signaling pathway in vivo and in vitro

Cheng

Liu

et al. 2020

Journal of Food Science

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The mechanism underlying the effect of ursolic acid (UA) on lipid metabolism remains unclear. This study aimed to explore the mechanisms of UA in reducing lipid accumulation in free fatty acids‐cultured HepG2 cells and in high‐fat‐diet‐fed C57BL/6J mice. In vivo, UA effectively alleviated liver steatosis and decreased the size of adipocytes in the epididymis. It also significantly decreased the total cholesterol (TC) and triglyceride (TG) contents in the liver and plasma in C57BL/6 mice. In vitro, UA (20 µM) significantly reduced lipid accumulation; the intracellular TC contents decreased from 0.078 ± 0.0047 to 0.049 ± 0.0064 µmol/mg protein, and TG contents from 0.133 ± 0.005 to 0.066 ± 0.0047 µmol/mg protein, in HepG2 cells. Furthermore, UA reduced the mRNA expression related to fat synthesis, enhanced the mRNA expression related to adipose decomposition, and dramatically upregulated the protein expression of P‐AMPK in vivo and in vitro. Of note, these protective effects of UA on a high‐fat environment were blocked by the AMPK inhibitor (compound C) in vitro. In addition, the molecular docking results suggested that UA could be docked to the AMPK protein as an AMPK activator. These results indicated that UA lowered the lipid content probably via activating the AMPK signaling pathway, thereby inhibiting lipid synthesis and promoting fat decomposition. Practical Application Ursolic acid (UA) widely exists in vegetables and fruits. This study highlighted a lipid‐lowing mechanism of UA in HepG2 cells and C57BL/6J mice. The data indicated that UA might be used in lipid‐lowering functional foods.

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Section: Resultsmentioning

confidence: 99%

Ursolic acid alleviates lipid accumulation by activating the AMPK signaling pathway in vivo and in vitro

Cheng

Liu

et al. 2020

Journal of Food Science

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“…A case-control study conducted in Han Chinese individuals supported our results, which showed that non-HDL-C is elevated in adults with prediabetes [ 30 ]. However, a cohort study previously proposed that non-HDL-C was more informative than traditional cholesterol indices in predicting the risk of diabetes for women but not for men with NGT, which demonstrated that cholesterol levels might be a sex-specific risk factor for diabetes [ 31 ]. In addition, our study showed that the AUC of non-HDL-C (0.705) was larger than that of the TG/HDL-C and TC/HDL-C ratios (0.692 and 0.686 respectively) to discriminate diabetes, which was inconsistent with an investigation in Tangshan, China [ 12 ].…”

Section: Discussionmentioning

confidence: 99%

Predictive performance of lipid parameters in identifying undiagnosed diabetes and prediabetes: a cross-sectional study in eastern China

Zhou

Yang

et al. 2022

BMC Endocr Disord

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Background Dyslipidaemia is a risk factor for abnormal blood glucose. However, studies on the predictive values of lipid markers in prediabetes and diabetes simultaneously are limited. This study aimed to assess the associations and predictive abilities of lipid indices and abnormal blood glucose. Methods A sample of 7667 participants without diabetes were enrolled in this cross-sectional study conducted in 2016, and all of them were classified as having normal glucose tolerance (NGT), prediabetes or diabetes. Blood glucose, blood pressure and lipid parameters (triglycerides, TG; total cholesterol, TC; high-density lipoprotein cholesterol, HDL-C; low-density lipoprotein cholesterol, LDL-C; non-high-density lipoprotein cholesterol, non-HDL-C; and triglyceride glucose index, TyG) were evaluated or calculated. Logistic regression models were used to analyse the association between lipids and abnormal blood glucose. The area under the curve (AUC) of the receiver operating characteristic (ROC) curve was used to assess the discriminatory power of lipid parameters for detecting prediabetes or diabetes. Results After adjustment for potential confounding factors, the TyG was the strongest marker related to abnormal blood glucose compared to other lipid indices, with odds ratios of 2.111 for prediabetes and 5.423 for diabetes. For prediabetes, the AUCs of the TG, TC, HDL-C, LDL-C, TC/HDL-C, TG/HDL-C, non-HDL-C and TyG indices were 0.605, 0.617, 0.481, 0.615, 0.603, 0.590, 0.626 and 0.660, respectively, and the cut-off points were 1.34, 4.59, 1.42, 2.69, 3.39, 1.00, 3.19 and 8.52, respectively. For diabetes, the AUCs of the TG, TC, HDL-C, LDL-C, TC/HDL-C, TG/HDL-C, non-HDL-C and TyG indices were 0.712, 0.679, 0.440, 0.652, 0.686, 0.692, 0.705, and 0.827, respectively, and the cut-off points were 1.35, 4.68, 1.42, 2.61, 3.44, 0.98, 3.13 and 8.80, respectively. Conclusions The TyG, TG and non-HDL-C, especially TyG, are accessible biomarkers for screening individuals with undiagnosed diabetes.

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“…Non-HDL cholesterol was previously reported to show a better performance for predicting diabetes than total, HDL, and LDL cholesterols in Canadian and southern Chinese populations, 21-23 and in women in an eastern Chinese population. 24 Our study added to the evidence that non-HDL cholesterol could be a better predictor of diabetes than total, HDL, and LDL cholesterols in the Ethiopian population.…”

Section: Discussionmentioning

confidence: 76%

Factors Associated With Prediabetes and Diabetes Among Public Employees in Northern Ethiopia

Chiang

Gebremariam

et al. 2020

Asia Pac J Public Health

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The increasing burden of diabetes mellitus is one of the major public health challenges in African countries, including Ethiopia. This is the first study aimed to identify factors associated with prediabetes and diabetes defined by both fasting blood glucose and glycated hemoglobin in Ethiopians. We analyzed data of a cross-sectional survey (1372 adults aged 25-64 years) conducted between October 2015 and February 2016; multinomial logistic regression models were applied. Abdominal obesity, total cholesterol, and non–high-density lipoprotein cholesterol were independently associated with prediabetes and diabetes in both sexes. Increased triglycerides and religious fasting practices were independently associated with prediabetes and diabetes only in men; hypertension was associated with prediabetes and diabetes only in women, while high-density lipoprotein cholesterol was not associated with prediabetes and diabetes in either sex. Sex differences in the association of triglycerides, hypertension, and dietary habit suggest that different approaches of lifestyle modification may be required for men and women.

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Non‐high‐density lipoprotein cholesterol is more informative than traditional cholesterol indices in predicting diabetes risk for women with normal glucose tolerance

Cited by 9 publications

References 27 publications

Ursolic acid alleviates lipid accumulation by activating the AMPK signaling pathway in vivo and in vitro

Ursolic acid alleviates lipid accumulation by activating the AMPK signaling pathway in vivo and in vitro

Predictive performance of lipid parameters in identifying undiagnosed diabetes and prediabetes: a cross-sectional study in eastern China

Factors Associated With Prediabetes and Diabetes Among Public Employees in Northern Ethiopia

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