Non‐Hodgkin lymphoma and obesity: A pooled analysis from the InterLymph Consortium

Willett, Eleanor V.; Morton, Lindsay M.; Hartge, Patricia; Becker, Nikolaus; Bernstein, Leslie; Boffetta, Paolo; Bracci, Paige M.; Cerhan, James R.; Chiu, Brian C.‐H.; Cocco, Pierluigi; Maso, Luigino Dal; Davis, Scott; Sanjosé, Sílvia de; Smedby, Karin E.; Ennas, Maria Grazia; Foretová, Lenka; Holly, Elizabeth A.; Vecchia, Carlo La; Matsuo, Keitaro; Maynadié, Marc; Melbye, Mads; Negri, Eva; Nieters, Alexandra; Severson, Richard K.; Slager, Susan L.; Spinelli, John J.; Staines, Anthony; Talamini, Renato; Vornanen, Martine; Weisenburger, Dennis D.; Roman, Eve

doi:10.1002/ijc.23344

Cited by 105 publications

(87 citation statements)

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“…All cases and controls (416 and 181 cases, and 2,260 and 966 controls in HER-PACC-I and HERPACC-II, respectively) pooled in the analysis of the InterLymph study were included in our study. 1 Our previous study confirmed the feasibility of using noncancer outpatients at our hospital as controls in epidemiological studies because their general lifestyles are accordant with those of a general population randomly selected from the electoral roll in Nagoya City. 32 Although the ACCH is called a cancer hospital, only 20 and 11% of all new male and female outpatients have cancer.…”

Section: Cases and Controlssupporting

confidence: 67%

“…[1][2][3][4][5][6][7][8][9][10][11] Moreover, most of these studies were conducted in non-Asian populations. Recently, the International Lymphoma Epidemiology Consortium (InterLymph) reported a large pooled analysis of 18 case-control studies conducted at various centers, including ours, to evaluate the impact of recent obesity on NHL risk, with the results suggesting no significant association between NHL and obesity.…”

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confidence: 99%

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Association between obesity and the risk of malignant lymphoma in Japanese: a case–control study

Kanda

Matsuo

Suzuki

et al. 2010

Intl Journal of Cancer

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Although marked differences in anthropometric characteristics and malignant lymphoma (ML) incidence suggest that the association between obesity and ML risk in Asian and non-Asian populations may differ, few studies have investigated this association in Asian populations. Here, we conducted a sex-and age-matched case-control study in a Japanese population using 782 cases and 3,910 noncancer controls in the hospital-based Epidemiological Research Program at Aichi Cancer Center Hospital. Odds ratios (ORs) and 95% confidence intervals (CIs) for anthropometric characteristics were estimated using a conditional logistic regression model that incorporated smoking and alcohol intake. Recent body weight and body mass index (BMI) showed marginally significant association with ML risk (ORs [95% CIs] per 5-unit increase in recent weight and BMI; 1.04 [0.99-1.09] and 1.11 [0.98-1.27], respectively). On the other hand, weight and BMI in early adulthood exhibited a strong association with ML risk (ORs [95% CIs] per 5-unit increase in early adulthood weight and BMI; 1.11 [1.05-1.18] and 1.33 [1.13-1.55], respectively). Further, in women, a BMI of 25.0-29.9 kg/m 2 , defined as obesity in Asian populations, during early adulthood was significantly associated with ML risk compared to the normal range of 18.5-22.9 kg/m 2 . By histological ML subtype, the point estimates of ORs for obesity relative to normal weight in early adulthood were over unity for nonHodgkin lymphoma (NHL) as a whole and significant for diffuse large B-cell lymphoma (DLBCL). In conclusion, our study in Japanese subjects suggested that early adulthood obesity is associated with the risk of NHL, particularly DLBCL.Although the association between obesity and the risk of non-Hodgkin lymphoma (NHL) and Hodgkin lymphoma (HL) has been investigated in a number of case-control and cohort studies, results have been inconsistent. 1-11 Moreover, most of these studies were conducted in non-Asian populations. Recently, the International Lymphoma Epidemiology Consortium (InterLymph) reported a large pooled analysis of 18 case-control studies conducted at various centers, including ours, to evaluate the impact of recent obesity on NHL risk, with the results suggesting no significant association between NHL and obesity. 1 In contrast, Maskarinec et al. 2 reported that body weight and body mass index (BMI) at age 21 were stronger predictors of NHL risk than baseline anthropometric characteristics, suggesting that weight during early adulthood may be a better indicator of NHL risk than weight at an older age. Further, increase in various cytokines among obese people has been proposed as a mechanism underlying the development of malignant lymphoma (ML); bioavailable insulin-like growth factor-1 (IGF-1) and insulin play a role in promoting cellular proliferation and inhibiting apoptosis, 12-14 whereas leptin is considered to be involved in lymphomagenesis via inflammatory pathways. [15][16][17][18][19] Because Asian populations generally have a low BMI but higher

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Section: Cases and Controlssupporting

confidence: 67%

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confidence: 99%

Association between obesity and the risk of malignant lymphoma in Japanese: a case–control study

Kanda

Matsuo

Suzuki

et al. 2010

Intl Journal of Cancer

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“…These results were in agreement with the findings of the study by Larsson and Wolk (17) in Sweden in 2011 as well as those by Litchman et al (18) in the United States in 2010 indicating where the BMI was positively associated with the increased risk of the NHL and the HL. The given findings were also consistent with the results of the study by Willet et al (19) suggesting that individuals with the BMI equal or more than 30, five years before the diagnosis of their disease had a greater risk of infection with HL. In a way that it was argued to have an initial focus on the prevention of cancer to reduce obesity.…”

Section: Discussionsupporting

confidence: 92%

Investigating Lifestyle and Dietary Style in Patients with Lymphoma of the Head and Neck Admitted to Razi Hospital in the City of Rasht

2018

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Background: In recent years, the incidence of various types of cancer including lymphoma has been on the rise. Although there have been developments in terms of knowledge of its biology and treatments, its etiology is still less known. In this respect, lifestyle and dietary factors can play important roles in the etiology of lymphoma. Thus, the purpose of the present study was to investigate the lifestyle and the dietary style in patients with lymphoma of the head and neck. Methods: This study was a retrospective case-control research. The patient group (57 people) was selected from the department of oncology at Razi hospital in the city of Rasht and the control group (57 individuals) was selected out of healthy individuals referred to Guilan school of dentistry. Then, both groups completed questionnaires concerning the research variables. After collecting the required information, the data were entered into the SPSS Software (version 21) to evaluate the dietary style and the lifestyle in the both groups. Results: Comparing the lifestyle in both study groups, the rate of smoking (P < 0.0001) as well as the body mass index (BMI) (P = 0.0001) in the patient group was higher than those in the control group. Moreover, comparing the dietary style in both groups showed that the rates of red meat intake (P = 0.005) in the patient group, and the consumption of fresh herbs (P = 0.009) and fruits (P = 0.043) in the control group were high. These differences were also statistically significant. Conclusions:The consumption of red meat, herbs, and fruit, as well as the body mass index were considered as predictors of lymphoma. Furthermore, smoking was directly correlated with the incidence of lymphoma.

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“…[17][18][19][20][21][22][23][24][25][26] Results from a meta-analysis by Larsson et al indicate that excess body weight may be a risk factor for NHL and MM, 27,28 whereas a pooled analysis from the InterLymph Consortium found no evidence to support the hypothesis that obesity is a determinant of all types of NHL combined. 29 Of the 19 published reports, [8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26] seven cohort studies focused on incident cases 10,[18][19][20][21][22]26 and two cohorts focused on mortality. 8,11 Although sexspecific 8,9,11,14,15,18,19,…”

Section: Introductionmentioning

confidence: 99%

Anthropometric characteristics and non-Hodgkin's lymphoma and multiple myeloma risk in the European Prospective Investigation into Cancer and Nutrition (EPIC)

Britton

Khan²,

Rohrmann³

et al. 2008

Haematologica

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Non‐Hodgkin lymphoma and obesity: A pooled analysis from the InterLymph Consortium

Cited by 105 publications

References 50 publications

Association between obesity and the risk of malignant lymphoma in Japanese: a case–control study

Association between obesity and the risk of malignant lymphoma in Japanese: a case–control study

Investigating Lifestyle and Dietary Style in Patients with Lymphoma of the Head and Neck Admitted to Razi Hospital in the City of Rasht

Anthropometric characteristics and non-Hodgkin's lymphoma and multiple myeloma risk in the European Prospective Investigation into Cancer and Nutrition (EPIC)

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