Non-Hodgkin Lymphoma Manifesting as Thyroid Nodules and Cardiac Involvement

Iqbal, Yasir; Al-Sudairy, Reem; Abdullah, Mohammad F.; Alomari, Ali; Crankson, Stanley

doi:10.1097/00043426-200312000-00017

Cited by 9 publications

(4 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In particular, in the 23 reports of Burkitt’s lymphoma, FNA cytology was performed in 12 patients (52%) and was able to provide the diagnosis without core needle or open surgical biopsy only in one case [ 12 ] (Table 1 ). Overall, in the reported cases of thyroid Burkitt’s lymphoma, diagnosis was provided by core needle biospy (43%; 10 cases out of 23), open surgery (35%; 8 cases out of 23), incisional/open wedge biopsy (17%; 4 cases out of 23), rarely by FNA (1 case out of 23) [ 12 ] or biopsy of other sites of involvement, such as a renal mass (1 cases out of 23) [ 10 ] (Table 1 ).…”

Section: Discussionmentioning

confidence: 99%

Usefulness of core needle biopsy for the diagnosis of thyroid Burkitt’s lymphoma: a case report and review of the literature

et al. 2018

View full text Add to dashboard Cite

BackgroundThyroid lymphomas are an exceptional finding in patients with thyroid nodules. Burkitt’s lymphoma is one of the rarest and most aggressive forms of thyroid lymphomas, and its prognosis depends on the earliness of medical treatment. Given the rarity of this disease, making a prompt diagnosis can be challenging. For instance, fine-needle aspiration (FNA) cytology, which is the first-line diagnostic test that is performed in patients with thyroid nodules, is often not diagnostic in cases of thyroid lymphomas, with subsequent delay of the start of therapy.Case presentationHere we report the case of a 52-year-old woman presenting with a rapidly enlarging thyroid mass. Thyroid ultrasonography demonstrated a solid hypoechoic nodule. FNA cytology was only suggestive of a lymphoproliferative disorder and did not provide a definitive diagnosis. It is core needle biopsy (CNB) that helped us to overcome the limitations of routine FNA cytology, showing the presence of thyroid Burkitt’s lymphoma. Subsequent staging demonstrated bone marrow involvement. The early start of an intensive multi-agent chemotherapy resulted in complete disease remission. At 60 months after the diagnosis, the patient is alive and has not had any recurrence.ConclusionsClinicians should be aware that thyroid Burkitt’s lymphoma is an aggressive disease that needs to be treated with multi-agent chemotherapy as soon as possible. To diagnose it promptly, they should consider to order/perform a CNB in any patient with a rapidly enlarging thyroid mass that is suspicious for lymphoma.

show abstract

Section: Discussionmentioning

confidence: 99%

Usefulness of core needle biopsy for the diagnosis of thyroid Burkitt’s lymphoma: a case report and review of the literature

et al. 2018

View full text Add to dashboard Cite

show abstract

“…Treatment for cardiac tumors may be curative or palliative and includes chemotherapy, surgical resection, or heart transplantation. [29][30][31] Cardiac tumors should be treated as soon as possible after discovery because of their possible lethal nature if left untreated. The anesthetic management of cardiac tumors requires a specialist in cardiac anesthesia who is knowledgeable in the aspects of cardiopulmonary bypass and echocardiography.…”

Section: Cardiovascular Emergenciesmentioning

confidence: 99%

Oncologic Emergencies: The Anesthesiologist's Perspective

Lew

Falabella

Moore-Jeffries

et al. 2007

J Natl Compr Canc Netw

View full text Add to dashboard Cite

Cancer is the second leading cause of death in the United States. During the course of treatment, a cancer patient may present emergently to the hospital because of either the cancer itself or a manifestation of cancer therapy. Rarely, patients with cancer can present to the operating room with several emergent conditions that require the services of an anesthesiologist. The main oncologic emergencies affecting anesthesiologists relate to airway obstruction and cardiac-, neurologic-, gastrointestinal-, and endocrine-related conditions. Mismanagement of these crises can increase morbidity and mortality. This article addresses emergencies in patients with cancer and how they relate to anesthetic care.

show abstract

“…This neoplasm is characterized by intermediate-sized lymphoid cells with a "starry sky" appearance and exhibits chromosomal translocations that activate the MYC oncogene [2,3]. To our knowledge, only 20 patients with primary thyroid BL have been described in the English-language literature [4][5][6][7][8][9][10][11][12][13][14][15][16]. Because of its extremely low prevalence, little is known about the pathogenesis and clinicopathological features of this disease, or about the differences between it and its systemic counterpart.…”

Section: Introductionmentioning

confidence: 99%

Clinicopathological features of primary thyroid Burkitt’s lymphoma: a systematic review and meta-analysis

et al. 2020

View full text Add to dashboard Cite

Background: Primary thyroid Burkitt's lymphoma (BL) is an extremely rare and highly aggressive form of non-Hodgkin's lymphoma; only isolated case reports are available for patients with this disease. Methods: We analyzed the clinicopathological features of thyroid BL by conducting a meta-analysis of 21 known patients (including ours) and compared them to those of extrathyroidal BL. Results: There were 13 men and 8 women with a median age of 39.3 years (range, 6-75 years). The median followup was 46.5 months (range, 0.5-361 months). Six patients (28.6%) had stage I disease, 2 (9.5%) had stage II, 2 (9.5%) had stage III, and 11 (52.4%) had stage IV. Five of 7 tested patients with thyroid BL (71.4%) had histological evidence of underlying Hashimoto's thyroiditis. Ki-67 labeling indices exceeding 90% in all 19 patients tested (100%). Fluorescence in situ hybridization performed on 12 patient samples revealed that all (100%) had MYC rearrangement. Among the 16 patients for whom follow-up data were available, 4 died of disease-related causes. Kaplan-Meier analysis revealed that the 12-and 60-month overall survival rates for patients with thyroid BL were 87.5 and 70.7%, respectively. Conclusions: Ours was the largest study of thyroid BL and its detailed clinicopathological features to date. Thyroid BL is not associated with underlying Epstein-Barr virus infection but is closely linked to Hashimoto's thyroiditis; patients generally have good overall survival and respond well to intensive chemotherapy. The correct pathological diagnosis is essential for treatment selection and outcome improvement.

show abstract

Non-Hodgkin Lymphoma Manifesting as Thyroid Nodules and Cardiac Involvement

Cited by 9 publications

References 6 publications

Usefulness of core needle biopsy for the diagnosis of thyroid Burkitt’s lymphoma: a case report and review of the literature

Usefulness of core needle biopsy for the diagnosis of thyroid Burkitt’s lymphoma: a case report and review of the literature

Oncologic Emergencies: The Anesthesiologist's Perspective

Clinicopathological features of primary thyroid Burkitt’s lymphoma: a systematic review and meta-analysis

Contact Info

Product

Resources

About