Non-Hodgkin lymphoma of bone in an HIV-infected patient from Argentina

Abstract

Introduction: Human immunodeficiency virus (HIV)-infected patients are at higher risk for development of Non-Hodgkin's lymphoma (NHL). The estimated incidence of NHL in patients with acquired immunodeficiency syndrome (AIDS) is much higher when compared to the general population. Most AIDS-associated NHL are of intermediate-or high-grade B-cell type and involve extranodal sites more frequently. The most common sites are the central nervous system (CNS), gastrointestinal tract, liver, bone marrow and soft tissues. Methodology: We describe a 42-year-old male with risk factors for HIV infection who presented with left leg pain and an osteolytic lesion of the left medial tibia. He was subsequently diagnosed with HIV disease and an open biopsy of his left tibia established the diagnosis of NHL. Results: After starting antiretroviral therapy followed by chemotherapy he achieved remission. Conclusion: Bone lymphomas account for 3% of malignant bone tumors and 4-7% of all extranodal sites. NHL of bone has been infrequently described in patients with AIDS. To our knowledge, this is the first report of NHL of the bone in Argentina.

Two cases of primary non‐Hodgkin's lymphoma of female breast: Role of fine‐needle aspiration cytology and cell‐block immunohistochemistry

“…HIV‐infection carries a significant risk association with extranodal lymphomas. Persistent immunodeficiency, antigenic incitation, immunoreactivity, deregulated cytokine response and dendritic/T‐cell activation; plus the opportunistic oncogenic viruses like Epstein‐Barr virus (EBV) and human herpesvirus‐8 (HHV‐8) play the pivotal role in the pathogenesis of HIV‐associated lymphoma . NHL arises at a median age of 65 years in general population, while that age declines down to as low as 37 years in PHA .…”

“…NHL emerges as the AIDS defining illness in about 3% HIV‐infected patients . In two consecutive studies Dhir et al calculated the prevalence of several HIV‐associated malignancies.…”

Osseous manifestations of non-Hodgkin's lymphoma in Human Immunodeficiency Virus (HIV) infection and Acquired Immunodeficiency Syndrome (AIDS)

“…5,6 Lymphoma is a haematopoietic neoplasm composed of malignant lymphoid cells affecting different parts of the body. The most common areas of involvement include lymph nodes, spleen, central nervous system, bone marrow and gastrointestinal tract.…”