Non-Hodgkin Lymphoma of the Central Skull Base

Han, Moon Hee; Chang, Kee Hyun; Kim, In One; Kim, Dong Kyu; Han, Man Chung

doi:10.1097/00004728-199307000-00009

Cited by 56 publications

(25 citation statements)

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“…5 Han et al demonstrated the MRI characteristics of non-Hodgkin's lymphoma of skull base and noted MRI findings of an erosive lesion of the skull base, invasion of the cavernous sinus without arterial narrowing, infiltration along the Dural surface and iso or hypo intensity within the brain on T2 weighted imaging should suggest lymphoma. 7 Similar features were seen in another study by Choi et al 1 These features are also consistent with what was seen on the MRI images of our patient.…”

Section: Discussionsupporting

confidence: 92%

Skull base non-Hodgkin’s lymphoma

2017

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Primary skull base lymphoma accounts for 1% - 2% of all skull base tumours. It is a very rare condition, which poses a diagnostic challenge in clinical practice but needs early diagnosis and treatment. We present a case of primary lymphoma of the skull base in a 53-year-old woman, who was admitted with complaints of bilateral temporal pain, facial numbness, slurred speech, difficulty in swallowing and deafness. Computed tomography (CT) and Magnetic Resonance Imaging (MRI) showed ill-defined destruction of the petrous temporal bone with a high signal area noted on T2 weighted images in the right temporal lobe which initially was thought to be skull base osteomyelitis. However, a finding of a thin subperiosteal dense soft tissue in the left parieto-occipital region with intact adjacent bone cortex similar in appearance to the of the primary skull base pathology was seen which alerted the team to possible diagnosis of skull base lymphoma.

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Section: Discussionsupporting

confidence: 92%

Skull base non-Hodgkin’s lymphoma

2017

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“…This atypical presentation of diffuse large B-cell lymphoma underscores the importance of considering the condition in a differential diagnosis of intracranial mass lesions. Certain radiological features of the tumour such as comparable signal intensities to brain parenchyma, its homogeneous nature and homogeneous enhancement with gadolinium may raise suspicion of the existence of a non-Hodgkin's lymphoma [3]. The existence of a dural tail similar to that seen in meningioma is another radiographic feature indicative of lymphoma reported previously [3,4].…”

Section: Discussionmentioning

confidence: 90%

An atypical cause of trigeminal neuralgia and panhypopituitarism

Coulter

Garrioch²,

Toft³

2010

BJR

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A 63-year-old man presented to the hospital accident and emergency department with an episode of syncope. He also gave a history describing several weeks of leftsided facial pain, which was initially thought to be secondary to a tooth abscess. On systemic enquiry the patient also reported having intermittent episodes of night sweats and mild anorexia, but he was otherwise well. Physical examination revealed the patient to have significant postural hypotension, allodynia affecting all three divisions of the trigeminal nerve and a palpable liver edge. Laboratory biochemistry investigations revealed profound panhypopituitarism.An MRI with gadolinium contrast of the brain subsequently revealed a hypothalamic mass sitting posterior to the optic chiasm and wrapping around the floor of the third ventricle with extension into the infundibulum. A second mass was also observed within Meckel's cave extending towards the foramen ovale. The masses appeared radiologically similar but anatomically separate (Figures 1 and 2).What is the differential diagnosis? What further investigations are indicated? DiagnosisRadiological assessment of the lesions initially suggested the possibility of (a) metastatic lesions including lymphoma; (b) two coincidental lesions, e.g. hypothalamic astrocytoma and trigeminal schwannoma; or (c) granulomatous pathology such as neurosarcoidosis. There is a 15612 mm hypothalamic mass that wraps around the floor of the third ventricle. The mass lateral to the cavernous sinus is situated within Meckel's cave and is likely to account for the left trigeminal nerve symptoms.

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“…B-NHL from mucosa-associated lymphoid tissue often arises in gastric mucosa and is extremely rare in the upper aerodigestive tract. Few cases with marginal-zone lymphoma and (more frequently) diffuse large B-cell lymphoma in the upper aerodigestive tract have been described [2,6,[8][9][10].…”

Section: Discussionmentioning

confidence: 99%