Non-Hodgkin Lymphoma of the jejunum presenting as perforation peritonitis: A case report

Warsinggih,; Darmadi, Suluh; Prihantono, Prihantono

doi:10.1016/j.amsu.2020.04.041

Cited by 4 publications

(3 citation statements)

References 15 publications

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“…Peritonitis is an inflammation of the peritoneal membrane of the abdominal cavity and the organs within it [ [1] , [2] , [3] ]; it is a surgical emergency condition associated with a high level of infectious complications, such as sepsis, septic shock, and death [ 1 , [4] , [5] , [6] ].…”

Section: Introductionmentioning

confidence: 99%

Transfer factor treatment in management of peritonitis condition: An experimental study in rat

Habar¹,

Islam²,

Hatta³

et al. 2021

Annals of Medicine &Amp; Surgery

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Background There is a role for the immune system in improving the outcome of peritonitis cases in children. Transfer factors are one immunomodulatory treatment that can increase the activity of natural killer (NK) cells to produce interferon-gamma (IFN-γ), which is thought to increase the phagocytic activity of macrophages. This study analyzed the effects of transfer factors on the phagocytic activity of macrophages in the intraperitoneal fluid of a Wistar rat model of peritonitis. Methods This experimental study had a post-test-only control group design and was carried out at the Laboratory of Pharmacology and Microbiology of Padjadjaran University, Bandung, Indonesia. It analyzed the effect of transfer factors on the phagocytic activity of macrophages in the intraperitoneal fluid of Wistar rats experiencing peritonitis after being injected with Escherichia coli . An unpaired comparative t -test was performed using the SPSS program to analyze the difference between transfer factor administration and macrophage phagocytic activity levels. Results There was a statistically significant difference between the phagocytosis index values of macrophages in samples treated with transfer factors and those that were untreated (p = 0.005). Conclusions Transfer factors increased the phagocytic activity of macrophages in a Wistar rat model of peritonitis. This suggests that transfer factors could have a role as an immunomodulatory treatment for peritonitis.

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Section: Introductionmentioning

confidence: 99%

Transfer factor treatment in management of peritonitis condition: An experimental study in rat

Habar¹,

Islam²,

Hatta³

et al. 2021

Annals of Medicine &Amp; Surgery

Self Cite

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“…Common acute abdominal diseases include appendicitis, gastric and intestinal perforation, volvulus, acute pancreatitis, and ectopic pregnancy. Therefore, in the majority of cases, the intestinal perforation can only be detected by laparotomy, and a de nite diagnosis can be made only after histopathological examination [3].We report the rare case of a male suffering from peritonitis with Non-Hodgkin Lymphoma located in small intestine and reported the case in accordance with the SCARE 2018 guidelines [4].…”

Section: Introductionmentioning

confidence: 99%

T-cell Non-Hodgkin Lymphoma of the Ileum Presenting as Perforation and Peritonitis: A Case Report

Yong

Zhang

et al. 2021

Preprint

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Background Non-Hodgkin Lymphoma (NHL) of the ileum presenting as perforation and peritonitis is a rare disease, derived from intestinal intraepithelial T lymphocytes.The degree of malignancy is extremely high. The pathogenic factors of ileal perforation caused by NHL are not clear yet, Chromosome and immune system abnormalities, which may be related to the NHL, are indistinguishable from other benign and malignant conditions and clinically nonspecific. Case presentation Here,We described an 84 year old male with abdominal pain for four days and aggravating for three hours. The pain was initially considered as gastrointestinal perforation, and was initially located at the upper abdomen area.The persistent insidious pain,and was accompanied by nausea, vomiting and fever. According to the abdominal physical examination, the patient had pain all over his abdomen, rebound pain and muscle tension, and bowel sounds were reduced on auscultation. The abdominal CT scan showed abdominal cavity free gas.We diagnosed the patient with peritonitis due to the perforation of the hollow viscus. We promptly performed exploratory laparotomy.Intraoperative findings,showed perforations in the ileum that were approximately 40 cm from the ileocecal region and had a size of 3～8 mm. Segmental distribution was observed, and the intestinal contents overflowed with purulent moss around the perforation surface. Resection and ileostomy were performed as intervention, and the clinical histopathological examination showed the T-cell lymphoma. Conclusion:Timely emergency surgery is the key to the treatment of the ileal perforation caused by T-cell lymphoma.Resection and ileostomy were performed as intervention, and the subsequent histopathological examination showed T-cell lymphoma. Clinical follow-up was performed, and the patient was advised to go to the oncology department for further chemotherapy.

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“…[11]. Treatment for gastrointestinal lymphoma depends on an accurate staging and diagnosis.Stage IITwo or more lymphatic regions on the same side of the diaphragm or a single extranodal organ with lymph node involvement on the same side of the diaphragm…”

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Multifocal Primary Extranodal Non-Hodgkin Lymphoma: A Report of a Rare Case

Kani,

Ravichandran,

Grace Priyadarshini

et al. 2024

Cureus

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Primary extranodal non-Hodgkin lymphoma (NHL) is a rare manifestation of lymphoid malignancies and typically arises in tissues outside the lymph nodes and can involve various organs and anatomical sites presenting unique challenges in diagnosis and treatment. Multifocal primary extranodal NHL, characterized by simultaneous involvement of multiple extranodal sites, presents a diagnostic and therapeutic challenge due to its uncommon presentation and varied clinical manifestations. Despite advances in diagnostic modalities and treatment strategies for NHL, multifocal involvement poses unique clinical dilemmas requiring a multidisciplinary approach for accurate diagnosis and optimal therapeutic intervention. In this case report, we describe a rare case of multifocal primary extranodal NHL in a 29-yearold female, highlighting the complexities associated with its diagnosis and management. Through this case presentation, we aim to underscore the importance of recognizing and addressing the intricacies of multifocal primary extranodal NHL to enhance clinical outcomes and improve patient care. It also highlights the diagnostic complexity and clinical challenges associated with multifocal primary extranodal NHL. A multidisciplinary approach involving haematologists, oncologists, radiologists, and pathologists is crucial for the accurate diagnosis and optimal management of such cases. Additionally, further research is warranted to better understand the underlying pathogenesis and improve treatment strategies for this rare presentation of NHL.

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Non-Hodgkin Lymphoma of the jejunum presenting as perforation peritonitis: A case report

Cited by 4 publications

References 15 publications

Transfer factor treatment in management of peritonitis condition: An experimental study in rat

Transfer factor treatment in management of peritonitis condition: An experimental study in rat

T-cell Non-Hodgkin Lymphoma of the Ileum Presenting as Perforation and Peritonitis: A Case Report

Multifocal Primary Extranodal Non-Hodgkin Lymphoma: A Report of a Rare Case

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Non-Hodgkin Lymphoma of the jejunum presenting as perforation peritonitis: A case report

Cited by 4 publications

References 15 publications

Transfer factor treatment in management of peritonitis condition: An experimental study in rat

Transfer factor treatment in management of peritonitis condition: An experimental study in rat

T-cell Non-Hodgkin Lymphoma&nbsp;of the&nbsp;Ileum&nbsp;Presenting as Perforation&nbsp;and Peritonitis: A Case Report

Multifocal Primary Extranodal Non-Hodgkin Lymphoma: A Report of a Rare Case

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T-cell Non-Hodgkin Lymphoma of the Ileum Presenting as Perforation and Peritonitis: A Case Report