Non-Hodgkin lymphoma with t(14;18): clonal evolution patterns and cytogenetic–pathologic–clinical correlations

Aamot, Hege Vangstein; Torlakovic, Emina; Eide, Marianne Brodtkorb; Holte, Harald; Heim, Sverre

doi:10.1007/s00432-006-0188-3

Cited by 20 publications

(19 citation statements)

References 39 publications

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“…Triple hit lymphomas were mostly represented by combinations of the t(8;22)(q24;q11) and a t(14;18)(q32;q21) (six of eight cases) (Stamatoullas et al, 2000;Henderson et al, 2004;D'Achille et al, 2006;Le Gouill et al, 2007;Johnson et al, 2009); one case had a t(2;8)(p12;q24) and t(18;22)(q21;q11) in combination (Au et al, 1999), and one case had both a t(8;14)(q24;q32) and t(14;18)(q32;q21) additionally to a BCL6 rearrangement (Aamot et al, 2007). No cases with four hits involving BCL6, MYC, BCL2, and CCND1 as reported in this study were found in the Mitelman database.…”

Section: Search Of the Mitelman Databasementioning

confidence: 96%

Several lymphoma‐specific genetic events in parallel can be found in mature B‐cell neoplasms

Bacher

Haferlach

Alpermann

et al. 2010

Genes Chromosomes & Cancer

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The mature B-cell neoplasms frequently result from translocations involving the IGH gene localized on 14q32. In rare instances, combinations of different IGH rearrangements were described, and even coincidence of three genetic lymphoma-specific events has been rarely reported. We here present eight patients with triple hit lymphoma, and two with four different lymphoma specific events detected by chromosome banding analysis and interphase FISH (seven males, three females, 47-82 years). All showed bone marrow involvement (Burkitt's lymphoma: n = 5, diffuse large B-cell lymphoma: n = 2; features intermediate between BL/DLBCL: n = 1; secondary aggressive B-cell lymphoma: n = 1; follicular lymphoma: n = 1). Eight patients had triple hit lymphoma combining IGH-BCL2/t(14;18)(q32;q21), MYC/8q24, and BCL6/3q27 rearrangements. Two showed an additional IGH-CCND1/t(11;14)(q13;q32) as fourth genetic event (according to research of the Mitelman database, the first reports on four genetic hits in lymphomas). All cases had complex aberrant karyotypes (median, 11 cytogenetic alterations per patient). Interphase FISH revealed a high rate of CDKN2A deletions (five of nine cases investigated; 56%), being homozygous in two of these cases. At the time of study, four of nine patients with follow-up data were alive (44%), one of these in remission. The two patients with four genetic hits died 6 and 9 days from diagnosis. Additional cases of lymphomas with three or four genetic hits should be collected to evaluate whether their clinical course differs from dual hit lymphomas.

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Section: Search Of the Mitelman Databasementioning

confidence: 96%

Several lymphoma‐specific genetic events in parallel can be found in mature B‐cell neoplasms

Bacher

Haferlach

Alpermann

et al. 2010

Genes Chromosomes & Cancer

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“…The karyotypes of the first biopsies from 40 of these patients have been published previously. 36 aCGH and statistical considerations DNA was isolated from frozen tissue with the use of the EZ1 tissue kit (QIAGEN). DNA copy number alterations (CNAs) were detected by aCGH on in-house arrays containing approximately 4500 Bacterial Artificial Chromosomes/P1-derived Artificial Chromosomes (BAC/PACs) in quadruplicate at an average resolution of 1 megabase.…”

Section: Patients and Biopsiesmentioning

confidence: 99%

Genomic alterations reveal potential for higher grade transformation in follicular lymphoma and confirm parallel evolution of tumor cell clones

Eide

Liestøl

Lingjærde

et al. 2010

Blood

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Our aim was to examine the genetics of clonal evolution in follicular lymphoma (FL) and to identify genetic alterations associated with disease progression. A total of 100 biopsies from 44 patients diagnosed with t(14;18)-positive FL were examined by array comparative genomic hybridization. In 20 patients the patterns of somatic hypermutations (SHMs) in the variable region of heavy chain gene were additionally analyzed. Gain of chromosome X in male samples was a marker for poor outcome (P < .01). Gains involving chromosome 2, 3q, and 5 were exclusively present in FL biopsies from cases with higher grade transformation and were among the copy number alterations (CNAs) associated with inferior survival.

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“…Weisenburger et al () showed an association between trisomy 21 and poor survival that was independent of t(14;18) in follicular large cell lymphoma. Aamot et al () showed that both trisomy 21 and the presence of more than six secondary cytogenetic aberrations correlated with a shorter OS in FL. However, these results were obtained from patients in whom the treatments were unknown or who were not treated with rituximab (Yunis et al , ; Weisenburger et al , ; Aamot et al , ).…”

Section: Discussionmentioning

confidence: 99%

“…Aamot et al () showed that both trisomy 21 and the presence of more than six secondary cytogenetic aberrations correlated with a shorter OS in FL. However, these results were obtained from patients in whom the treatments were unknown or who were not treated with rituximab (Yunis et al , ; Weisenburger et al , ; Aamot et al , ). To our knowledge, only one report mentioned that patients with 6q‐ had a shorter OS in an R‐CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone)‐like treatment group (Tsukamoto et al , ).…”

Section: Discussionmentioning

confidence: 99%

Prognostic impact of trisomy 21 in follicular lymphoma

et al. 2018

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Summary The chromosomal abnormalities associated with follicular lymphoma (FL) prognosis are not fully elucidated. Here, we evaluated the pattern of chromosomal abnormalities in FL, and clarified the correlations between the cytogenetic features and clinical outcome. Cytogenetic analysis was performed using standard methods of Giemsa‐banding at diagnosis for 201 FL patients admitted to our hospitals between 2001 and 2013. The identified chromosomal abnormalities were: t(14;18)(q32;q21) (59·2%), +X (17·9%), del(6)(q)/‐6 (16·9%), +7 (14·4%), abnormality of 1q12‐21/1q (12·9%), del(13)(q)/‐13 (11·9%), abnormality of 3q27 (10·4%), abnormality of 10q22‐24 (10·0%), +12/dup(12)(q) (10·0%), abnormality of 1p21‐22/1p (9·0%), +18 (9·0%), del(17)(p)/‐17 (5·0%), and a complex karyotype (54·7%). Patients with trisomy 21 had a significantly shorter progression‐free survival (P = 0·00171) and overall survival (OS) (P < 0·001) than those without trisomy 21; additionally, patients with trisomy 21 in the rituximab‐treated cohort also had a significantly shorter OS (P = 0·000428). Multivariate analysis identified trisomy 21 as an independent risk factor in our cohorts with or without t(14;18) (P = 0·015). In conclusion, the presence of trisomy 21 was an independent risk factor for in FL. Chromosomal analysis of FL patients at diagnosis can provide useful information about their expected survival.

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Non-Hodgkin lymphoma with t(14;18): clonal evolution patterns and cytogenetic–pathologic–clinical correlations

Abstract: Secondary chromosomal aberrations showed some correlation with the morphologic subgroups of t(14;18)-NHL. Trisomy 21 and the presence of >6.0 secondary cytogenetic aberrations both correlated with shorter overall survival.

Cited by 20 publications

References 39 publications

Several lymphoma‐specific genetic events in parallel can be found in mature B‐cell neoplasms

Several lymphoma‐specific genetic events in parallel can be found in mature B‐cell neoplasms

Genomic alterations reveal potential for higher grade transformation in follicular lymphoma and confirm parallel evolution of tumor cell clones

Prognostic impact of trisomy 21 in follicular lymphoma

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