Non-Hodgkin's Lymphoma in Childhood: Epidemiologic Features

Grundy, Gordon W.; Creagan, Edward T.; Fraumeni, Joseph F.

doi:10.1093/jnci/51.3.767

Cited by 28 publications

(6 citation statements)

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“…The slight elevation of the risk of brain tumors in the mothers of children with lymphoma, although based on few observations, is consistent with previous reports of familial tumor complexes. 29 The high risk of melanoma among fathers of children with retinoblastoma is an intriguing finding, given that children with heritable retinoblastoma are prone to have melanoma as a second tumor 30 (however, the finding in our study occurred in children with unilateral disease 19 ). A link between melanoma and retinoblastoma has also been noted in case reports, 31 as well as an accompanying association with the dysplastic nevus syndrome.…”

Section: Discussionmentioning

confidence: 44%

Cancer in the Parents of Children with Cancer

Olsen

Boice²,

Seersholm

et al. 1995

N Engl J Med

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Section: Discussionmentioning

confidence: 44%

Cancer in the Parents of Children with Cancer

Olsen

Boice²,

Seersholm

et al. 1995

N Engl J Med

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“…It is a large, but selected, cohort study, not limited to a single institution or small group of families, specific diagnostic group, twin studies, or analyses of family cancers by death certificates, methodologies employed in other studies (13,14,(16)(17)(18)(19)(21)(22)(23)(24). In this survivor cohort, highly lethal tumors, such as brain tumors, are not represented; thus, an increased risk of cancer among CNS tumor probands may not have been appreciated.…”

Section: Discussionmentioning

confidence: 99%

“…Studies of cancer among siblings of childhood cancer patients show increased risk, but results differ greatly depending on the sample size, mechanism of ascertainment, inclusion of twin pairs, and specific childhood cancer diagnoses (13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24). Studies of cancer risk in offspring of childhood cancer survivors have suggested that the risk is low, outside of the known cancer predisposition syndromes (25)(26)(27).…”

Section: Introductionmentioning

confidence: 99%

Increased Risk of Cancer among Siblings of Long-term Childhood Cancer Survivors: A Report from the Childhood Cancer Survivor Study

Friedman

Kadan‐Lottick

Whitton

et al. 2005

Cancer Epidemiology, Biomarkers &Amp; Prevention

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We determined risk of cancer among first-degree relatives of 5-year survivors of childhood leukemia, lymphoma, central nervous system tumors, sarcomas, Wilms' tumor, and neuroblastoma. Subjects were 13,703 participants in the Childhood Cancer Survivor Study. Family history was collected on 56,759 first-degree relatives using a selfreported questionnaire. Incidence was compared with age-and sex-specific rates using the U.S. Surveillance, Epidemiology and End Results program. Siblings of the survivors had an increased risk of cancer [standardized incidence ratio (SIR), 1.5; 95% confidence interval (95% CI), 1.35-1.7]. Risk was elevated for siblings of probands of leukemia (SIR, 1.3; 95% CI, 1.0-1.6), Hodgkin's disease (SIR, 1.5; 95% CI, 1.2-1.9), non-Hodgkin's lymphoma (SIR, 1.8; 95% CI, 1.3-2.5), Wilms' tumor (SIR, 1.9; 95% CI, 1.2-3.2), soft tissue sarcoma (SIR, 1.5; 95% CI, 1.0-2.2), and bone tumors (SIR, 1.6; 95% CI, 1.2-2.2). Cancer risk was elevated in siblings (SIR, 2.4; 95% CI, 1.5-3.7) and offspring (SIR, 15.0; 95% CI, 5.3-42.9) of probands with second malignant neoplasms (SMN) compared with relatives of probands without SMNs. Siblings of probands with leukemia, Hodgkin's disease, neuroblastoma, and Wilms' tumor had elevated risks for the same malignancies. Parents had no increased risk (fathers' SIR, 0.7; 95% CI, 0.7-0.8; mothers' SIR, 0.9; 95% CI, 0.9-1.0). Seventy percent of siblings' cancers developed in adulthood. These findings suggest that familial cancer syndromes may be revealed as this cohort and family members age and with accrual of more offspring and subjects with SMNs. (Cancer Epidemiol Biomarkers Prev 2005;14(8):1922 -7)

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“…3) three siblings with childhood acute lymphocytic leukemia, malignant schwannoma, and osteogenic sarcoma, respectively, associated with brain tumor in adulthood in the father;' 4) two siblings with Ig A deficiency, associated in one child with lymphoma and in the other with astrocytoma and other cancers;' 5) female twins with childhood brain tumor and lymphoma, respectively, and another pair with glioblastoma and both osteosarcoma and acute leukemia, respectively. 8,20 In addition, a survey of 900 children with non-Hodgkin's lymphoma revealed four patients with a second primary neoplasm of the brain, and 10 patients who had a sibling with brain tumor, leukemia, or lymphoma;' these frequencies were considered excessive. Other studies have also reported aggregation of the neoplasms in the same patient26*2Q,a0 or in families.…”

Section: Discussionmentioning

confidence: 99%

Double primary cancers in 2 young sibs, leukemia in another, and dextrocardia in a fourth

Li¹,

McIntosh²,

Peng-Whang³

1977

Cancer

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Two brothers developed multiple primary neoplasms in childhood; one had glioblastoma and non-Hodgkin's lymphoma at age 11 years, and the other brain tumor and acute leukemia at six years. A third brother died with myelogenous leukemia at three years, and a fourth with cyanotic congential heart disease at 11 weeks. Each child aiso had at least one hamartomatous lesion of the skin. The clinical features suggested von Recklinghausen's neurofibromatosis or other inherited cancer syndrome, but laboratory studies identified no markers of susceptibility to familial neoplasia.Cancer 39:2633-2636, 1977. AMILY STUDIES CAN PROVIDE CLUES TO CAUSESF of cancer in man. This report examines etiologic factors in the development of multiple primary malignancies in two young brothers, and myelogenous leukemia in a third; the family was mentioned in a prior survey of childhood cancers in siblings. CASE REPORTS AND FAMILY HISTORYPatient 111-2 (Fig 1) The proband, a n 1 1-year-old Caucasian boy, was hospitalized in 1974 at the Yale-New Haven Hospital because of a n anterior mediastinal mass. Past medical history revealed accidental ingestion of petroleum without acute toxic effects at age 7 years. Physical examination showed a 3 cm X 6 cm cafe-au-lait spot on the right cheek, and several punctate flat pigmented nevi on the face and trunk. Peripheral blood and bone marrow examinations were normal. Thoracotomy showed a diffuse, poorly differentiated lym-

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Non-Hodgkin's Lymphoma in Childhood: Epidemiologic Features

Cited by 28 publications

References 0 publications

Cancer in the Parents of Children with Cancer

Cancer in the Parents of Children with Cancer

Increased Risk of Cancer among Siblings of Long-term Childhood Cancer Survivors: A Report from the Childhood Cancer Survivor Study

Double primary cancers in 2 young sibs, leukemia in another, and dextrocardia in a fourth

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