Non-Hodgkin's Lymphoma Involving the Ileocecal Region

Zhai, Linzhu; Zhao, Yuanyuan; Lin, Lizhu; Tian, Ying; Chen, Xinggui; Huang, He; Lin, Tongyu

doi:10.1097/mcg.0b013e318237126c

Cited by 18 publications

(8 citation statements)

References 18 publications

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“…And lastly, NSAIDs, Eosinophilic enteritis and malignancies have been described in literature as cause of ulcerations in ileo-cecal region[3,14,19]. These causes were also noted in our study.…”

Section: Discussionsupporting

confidence: 82%

All ileo-cecal ulcers are not Crohn’s: Changing perspectives of symptomatic ileocecal ulcers

Toshniwal¹,

Chawlani²,

Thawrani³

et al. 2017

WJGE

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AIMTo investigated clinical, endoscopic and histopathological parameters of the patients presenting with ileocecal ulcers on colonoscopy.METHODSConsecutive symptomatic patients undergoing colonoscopy, and diagnosed to have ulcerations in the ileocecal (I/C) region, were enrolled. Biopsy was obtained and their clinical presentation and outcome were recorded.RESULTSOut of 1632 colonoscopies, 104 patients had ulcerations in the I/C region and were included in the study. Their median age was 44.5 years and 59% were males. The predominant presentation was lower GI bleed (55, 53%), pain abdomen ± diarrhea (36, 35%), fever (32, 31%), and diarrhea alone (9, 9%). On colonoscopy, terminal ileum was entered in 96 (92%) cases. The distribution of ulcers was as follows: Ileum alone 40% (38/96), cecum alone 33% (32/96), and both ileum plus cecum 27% (26/96). The ulcers were multiple in 98% and in 34% there were additional ulcers elsewhere in colon. Based on clinical presentation and investigations, the etiology of ulcers was classified into infective causes (43%) and non-infective causes (57%). Fourteen patients (13%) were diagnosed to have Crohn’s disease (CD).CONCLUSIONNon-specific ileocecal ulcers are most common ulcers seen in ileo-cecal region. And if all infections are clubbed together then infection is the most common (> 40%) cause of ulcerations of the I/C region. Cecal involvement and fever are important clues to infective cause. On the contrary CD account for only 13% cases as a cause of ileo-cecalulcers. So all symptomatic patients with I/C ulcers on colonoscopy are not Crohn’s.

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Section: Discussionsupporting

confidence: 82%

All ileo-cecal ulcers are not Crohn’s: Changing perspectives of symptomatic ileocecal ulcers

Toshniwal¹,

Chawlani²,

Thawrani³

et al. 2017

WJGE

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“…Primary gastrointestinal NHL is rare, accounting for only 1% to 4% of malignancies originating from the stomach, small intestine, or colon. 7 – 11 B-cell lymphoma is the third most common colorectal malignancy after colorectal cancer and neuroendocrine tumors, with an incidence of <0.5%. 5 – 7 DLBCL is the most common histological subtype of gastrointestinal lymphoma, and is more aggressive than other B-cell lymphomas.…”

Section: Discussionmentioning

confidence: 99%

Primary colonic lymphoma: report of two cases and a literature review

et al. 2021

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Primary colonic lymphoma is a very rare malignant tumor with no standard treatment. We report two cases of primary colonic lymphoma successfully treated with surgery and chemotherapy, and chemotherapy alone, respectively. The first case was a 61-year-old woman who presented with abdominal pain of more than 1 month. The patient was diagnosed with a colonic tumor, and immunohistochemical examinations confirmed the initial diagnosis of colonic lymphoma. The patient underwent laparoscopic-assisted right hemicolectomy followed by postoperative adjuvant chemotherapy with the cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) regimen, combined with targeted therapy with rituximab (R-CHOP). The second case was a 78-year-old man who presented with a complaint of abdominal distention for more than 1 year. Diffuse large B-cell lymphoma was definitively diagnosed by immunohistochemical examinations, and the patient underwent systemic chemotherapy with the R-CHOP regimen. Primary colonic lymphoma is a rare type of non-Hodgkin's lymphoma (NHL), and the clinical treatment is not standardized, unlike for many other types of lymphoma. Therefore, treatment is mainly based on the patient’s symptoms to determine whether surgery or systemic chemotherapy is appropriate. Rituximab is effective in some patients and may play an important role in the treatment of unresectable or asymptomatic colonic lymphoma.

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“…There have been reports of delayed CRS that occurred weeks after CAR T-cell infusion [ 13 - 15 ]. The late manifestation of CRS seemed to be related with late in vivo CAR T-cell expansion [ 11 ]. GI complications in lymphoma patients after CAR T-cell therapy were rare in clinical trials.…”

Section: Discussionmentioning

confidence: 99%

Delayed Terminal Ileal Perforation in a Relapsed/Refractory B-Cell Lymphoma Patient with Rapid Remission Following Chimeric Antigen Receptor T-Cell Therapy

Wang

et al. 2018

Cancer Res Treat

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Chimeric antigen receptor T-cell strategy targeting CD19 (CART19) has prominent anti-tumor effect for relapsed/refractory B-cell lymphomas. CART19-associated complications have been gradually recognized, however, late-onset complications have not been extensively studied. Herein, for the first time we report a diffuse large B-cell lymphoma patient with terminal ileum involvement obtained rapid remission and developed spontaneous terminal ileal perforation 38 days following CART19 infusion. The late-onset perforation reminds us that, for the safety of CART treatment, more cautions are warranted for the management of delayed GI complications.

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Non-Hodgkin's Lymphoma Involving the Ileocecal Region

Cited by 18 publications

References 18 publications

All ileo-cecal ulcers are not Crohn’s: Changing perspectives of symptomatic ileocecal ulcers

All ileo-cecal ulcers are not Crohn’s: Changing perspectives of symptomatic ileocecal ulcers

Primary colonic lymphoma: report of two cases and a literature review

Delayed Terminal Ileal Perforation in a Relapsed/Refractory B-Cell Lymphoma Patient with Rapid Remission Following Chimeric Antigen Receptor T-Cell Therapy

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