Non-Hodgkin's lymphoma with uncommon clinical manifestations: A case report

Abstract

Abstract. Extranodal lymphoma occurs in ~40% of all patients with lymphoma and has been described in virtually all organs and tissue. However, diffuse large B-cell lymphoma (DLBCL), which is the most common histological subtype of non-Hodgkin's lymphoma (NHL), primarily arising in the retroperitoneal region has been rarely reported. Primary retroperitoneal lymphoma without renal or ureteral involvement affecting the genitourinary system has not been reported until now. In this article, we report the rare case of a young female suffering with primary DLBCL located simultaneously in the retroperitoneal and gastrointestinal region. The first sign of this disease was renal colic. Pathological assessment was performed using immunohistochemistry staining, revealing positivity for CD20 and Ki67. DLBCL was the final confirmed diagnosis. Obtaining a definitive histological diagnosis by surgery and using exactly chemotherapy played an essential role in the treatment of our patient. This case serves as a reminder to include the differential diagnosis of primary retroperitoneal NHL when a patient presents with a retroperitoneal mass and the first symptom is renal colic.

Precursor T-Lymphoblastic Lymphoma Presenting With Cough: A Case Report

“…Cai et al have reported a case of a girl child who was diagnosed with primary DLBCL in the retroperitoneal as well as gastrointestinal regions at the same time. Renal colic was the initial indication of this condition, which was unusual [ 6 ]. Remnants of the thymus are often found in the mediastinal mass, and this may lead to a mistaken diagnosis of thymoma.…”

Aggressive Lymphoma “Sarcoma Mimicker” Originating in the Gluteus and Adductor Muscles: A Case Report and Literature Review

“…About 30%–40% of all NHL cases arise from sites other than lymph nodes, spleen, or bone marrow. 1,2,8 They may also arise from sites typically devoid of lymphocytes. Almost half of all ENL cases reported had DLBCL histology.…”

“…Extranodal involvement may also be due to the regional spread of nodal disease or hematogenous dissemination. 1,2,8 Primary skeletal muscle NHL of diffuse large B-cell immunophenotype is exceptionally rare (incidence rate of 0.1%-0.5% in all extranodal lymphoma (ENL) of the extremities). [5][6][7] However, diffuse large B-cell lymphoma (DLBCL), which is the most common histological subtype of NHL, primarily arising in the retroperitoneal region, has rarely been reported.…”

“…A few cases have been reported in the available literature. 2 Despite advances in imaging devices over the past decade, accurate diagnosis of soft tissue tumors remains a challenge for clinicians, requiring a close team approach between the surgical oncologist, musculoskeletal radiologist, and pathologist. 3 Elkourashy et al electrolytes were normal.…”

Primary extra-nodal indolent B-cell lymphoma (small lymphocytic lymphoma/chronic lymphocytic leukemia) of retroperitoneum

“…[2] Also, several cases of diffuse large B-cell lymphoma have been reported. [3,4] Non-Hodgkin lymphoma is now classified according to WHO classification in which lymphomas are roughly classified into B, T, NK, null, lymphoblastic, and unclassifiable lymphomas. [5][6][7][8][9][10][11][12][13] Primary indolent B-cell lymphoma is a category of B-cell lymphoma comprising of follicular lymphoma, mantle cell lymphoma, lympho-plasmacytic lymphoma, mucosa-associated lymphoid tissue (MALT) lymphoma, and small lymphocytic lymphoma/chronic lymphocytic lymphoma.…”