Non-Hodgkin's lymphomas and pregnancy: Presentation of 16 cases

Mycosis fungoides and pregnancy.

“…The interaction of pregnancy and NHL is difficult to assess because of the relative paucity of cases (7,8). Although some authors have suggested than NHL in pregnancy is most commonly associated with aggressive histology and disseminated disease (9,10), others have found no influence on the course of treated or untreated NHL (8).…”

Mutagenwirkungen in Keimzellen und frühen Embryonalstadien

“…Einige Beispiele mögen diese Spanne erläutern: in 20 Fällen einer in-utero-Exposition zu verschiedenen Zeitpunkten der Gravidität gegen diverse zytostatische Antibiotika fand sich keine Fehlbildung bei den Neugeborenen, für Busulfan wird eine Fehlbildungsrate von 10 % für Cyclophosphamid von 22 %, für Aminopterin von 53 %, für Azathioprin von 1 %, für Cytarabin von 15 %, für Merkaptopurin von 3 %, für Methotrexat von 6 % und für Vincristin von 8 % angegeben. Demgegenüber schlossen Aviles et al (1990) aus ihrer Studie an 16 Neugeborenen von Müttern, die sich in der Schwangerschaft einer Non-Hodgkin-Lymphom-Therapie unterziehen muûten, ¹That pregnancy is not a contraindication for treatment of Non-Hodgkin-Lymphomaª. Zum gleichen Ergebnis kam eine Studie über eine Radiotherapie des Morbus Hodgkin während der Schwangerschaft (Woo et al 1992 Balan et al 1992Casara et al 1993Smith et al 1994Schlumberger et al 1996Ehrenheim et al 1997 Thorotrtast Dodds et al 1993Malamos et al 1996Seersholm et al 1997 Chemotherapie…”

Ultrasonographic Appearance of Non-Hodgkin’s Lymphoma in a Pregnant Woman

“…There has also been apprehension about the use of cytotoxic drugs or radio therapy in pregnant women with a neoplasm because of possible teratogenic effects. But recently a number of reports have increasingly documented the delivery of nor mal infants to mothers with NHL who received aggressive chemotherapy or radiotherapy [1][2][3]. However, the possi ble harm of these tratments to the unborn fetus is still of great concern.…”

“…It is currently recommended that if the disease is detected in the early stages of pregnancy, even in the first trimester, immediate initiation of chemotherapy is cru cial for the survival of mother and child [3], If NHL is diagnosed close to full term, during the last month of preg nancy, one could wait for delivery in order to avoid possi ble complications of aggressive chemotherapy and in this instance treatment should be started immediately after delivery. On the other hand, in cases of high-grade lym Non-Hodgkin's Lymphoma during Pregnancy phomas such as Burkitt lymphoma, delaying the therapy may not be wise and treatment should be started earlier.…”