Non-hodgkin's lymphomas in turkey

Sarpel, Suleyman; Paydaş, Semra; Tuncer, İlhan; Varinli, Seyhan; Koksal, Mete; Akoğlu, T

doi:10.1002/1097-0142(19881015)62:8<1653::aid-cncr2820620833>3.0.co;2-0

Cited by 18 publications

(13 citation statements)

References 21 publications

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“…When data of the studies performed in USA, Europe, and Asia, using Ann Arbor staging system, 45-54 % of NHL patients were at an advanced stage of their disease at the time of diagnosis [20][21][22][23]. In our study, 63.9% of our patients were at an advanced stage of their disease (stage 3-4) at the time of diagnosis which is higher than those reported in various literature studies.…”

Section: Discussioncontrasting

confidence: 55%

Clinical and pathological evaluation of histopathological subtypes in patients with non-Hodgkin’s lymphoma

2016

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Objectives. Non-Hodgkin Lymphomas (NHLs) are tumours of the lymphoid system which originate from lymph nodes or extranodal lymphatic tissue. Since they represent a heterogeneous group of diseases, it is very important to determine prognostic factors apart from staging and identification of the patients with poor prognosis. The objective of our study is to investigate clinical characteristics, treatments applied, and their outcomes, survival rates, and prognostic factors which may be effective on survival. Methods. Clinical characteristics, treatments applied, and their outcomes, survivals, and prognostic factors which may be effective on the survival in 230 patients who were diagnosed as NHL, and consulted to our center between the years 2002, and 2015 were retrospectively evaluated. Results. Median age of our patients (male, 54.8 %, and female, 45.2 %) was 57 years. The most frequently seen histopathological subtype was diffuse large β cell lymphoma. We have seen that IPI score, β symptom, levels of LDH, albumin, β2 microglobulin, and lymphocyte counts are significant prognostic factors. Stomach was the most frequently involved extranodal organ. Advanced stage, higher IPI score, extranodal organ involvement were found to be correlated with shorter survival times. Conclusion. Everyday developments occur in the diagnosis, classification, and treatment of NHL. Therefore, it is important for medical centres to evaluate their treatment outcomes, and prognostic factors affecting their survival rates.Eur Res J 2016;2(1):52-61

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Section: Discussioncontrasting

confidence: 55%

Clinical and pathological evaluation of histopathological subtypes in patients with non-Hodgkin’s lymphoma

2016

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“…Primary extranodal lymphoma constitutes 25% of the NHL cases in North America and up to 50% in parts of Europe, Turkey, and Middle Eastern countries 3-5. The incidence of GI lymphoma is higher in Eastern Countries than Western Countries 4-6. High grade histopathologic types of gastric lymphomas are higher in Turkey and Middle East Countries than Western Countries 3-6…”

Section: Introductionmentioning

confidence: 99%

Clinicopathologic Characteristics and Therapeutic Outcomes of Primary Gastrointestinal Non-Hodgkin's Lymphomas in Central Anatolia, in Turkey

et al. 2006

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Primary gastrointestinal lymphoma is a common presentation of non-Hodgkin's lymphoma. The main controversy arises when many aspects of its classification and management are under discussion, particularly regarding roles for surgical resection. The aim of this study was to evaluate clinicopathologic characteristics and the therapeutic outcome of primary gastrointestinal non-Hodgkin's lymphoma. We carried out a retrospective analysis of 74 patients who were presented to our center with histopathological diagnosis of primary gastro-intestinal non-Hodgkin's lymphoma between 1990 and 2001. All patients have been staged according to Lugano Staging System. For histopathological classification, International Working Formulation was applied. The treatment choice concerning the surgical or non-surgical management was decided by the initially acting physician. Treatment modalities were compared using the parameters of age, sex, histopathological results, stage, and the site of disease. Of the 74 patients, 31 were female and 43 were male, with a median age of 49 years (range 15-80). The stomach was the most common primary site and was seen in 51 of 74 patients (68.9%). The intermediate and high grade lymphomas constituted 91.9% of the all cases. In a median follow-up of 29 months (range 2-128), 20 out of 74 patients died. There was a three year overall survival rate in 65.4% of all patients. The three year overall survival rate was better in stage I and II1 patients who were treated with surgery plus chemotherapy (+/-RT) than those treated with chemotherapy alone (93.7% vs. 55.6%, p < 0.05). The stage and presence of B symptoms affected the disease free survival and overall survival significantly, but the histopathologic grade only affected the overall survival. On the basis of these results, we suggest that surgical resection is necessary before chemotherapy in early stage (stage I and II1) patients with gastrointestinal non-Hodgkin's lymphomas because of the significant survival advantage it would bring to the patient.

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“…Two studies of gastrointestinal lymphoma patients from Ç ukurova University 16,17 reported gastric lymphomas to be the major form of gastrointestinal lymphoma whereas a previous report from our center 18 and another one from Ankara University found intestinal lymphomas to be the most common gastrointestinal lymphomas. This issue was not addressed in this study, and sufficient epidemiologic data are lacking at the moment to draw conclusions.…”

Section: Discussionmentioning

confidence: 79%

“…[1][2][3] One striking difference in this analysis of 78 gastric lymphoma patients from Turkey is the notably younger age distribution that also was reported in other Turkish series. [15][16][17][18][19] Gastric lymphoma is a disease occurring later in life. Most of the cases are diagnosed after the age of 50 years, with a mean age older than 55 in most published series.…”

Section: Discussionmentioning

confidence: 99%