NON‐IgE‐MEDIATED ASTHMA IN CHILDREN

Pa, Ostergaard

doi:10.1111/j.1651-2227.1985.tb10019.x

Cited by 41 publications

(14 citation statements)

References 9 publications

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“…It is thus questionable, whether a distinction of "extrinsic" and "intrinsic" asthma should be based on the presence or absence of an elevated serum concentration of IgE [34]. Further studies are clearly warranted to elucidate whether these observations represent a causal, pathogenic, or noncausal association.…”

Section: Discussionmentioning

confidence: 99%

Elevation of total serum immunoglobulin E is associated with asthma in nonallergic individuals

Beeh¹,

Ksoll²,

Buhl³

2000

Eur Respir J

138

102

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Elevated serum immunoglobulin (Ig)E is the hallmark of atopy, and contributes to asthma and bronchial hyperresponsiveness in atopic individuals. In contrast, the significance of IgE in nonallergic subjects is less clear. The aim of the present study is to clarify a potential association of IgE and asthma in absence of clinical allergy.To this purpose 1,219 consecutive patients of a pulmonary practice were evaluated. Nonallergic patients were defined by negative skin prick test, history of atopy and specific IgE, 509 subjects (42%) were nonallergic. Among these, 80 patients (16%) had elevated total IgE levels (>150 U . mL -1 ). Prevalence and severity of asthma in nonallergic subjects with IgE>150 U . mL -1 were compared with subjects with normal IgE levels, and lung function parameters were correlated with serum IgE in all nonallergic subjects and asthmatics.Asthma was more prevalent in nonallergic subjects with elevated IgE levels than in nonallergic subjects with normal IgE (39% versus 14%; p<0.001). Lung function values of nonallergic asthmatics were lower for forced expiratory volume in one second (FEV1) % predicted (66+20% versus 8317%; p<0.001), FEV1% forced vital capacity (FVC) (7014% versus 818%; p<0.001) and forced mid expiratory flow (FEF25±75) (1.70.9 L . s -1 versus 2.80.9 L . s -1 ; p=0.002) in patients with high IgE compared to asthmatics with normal IgE, and were negatively correlated with log IgE levels in all nonallergic asthmatics. (FEV1 % pred: r=-0.5, p<0.001; FEV1 % FVC: r=-0.53, p<0.001; FEF25±75: r=-0.52, p<0.001). In the whole study population, multivariate analysis showed a greater than fivefold asthma risk for nonallergic individuals with serum IgE>150 U . mL -1 . These data support the role of IgE as risk factor for asthma independent of allergy, and they further challenge the definition of intrinsic asthma as "non-IgE mediated" entity. Eur Respir J 2000; 16: 609±614.

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Section: Discussionmentioning

confidence: 99%

Elevation of total serum immunoglobulin E is associated with asthma in nonallergic individuals

Beeh¹,

Ksoll²,

Buhl³

2000

Eur Respir J

138

102

View full text Add to dashboard Cite

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“…These disorders are well-known Th1-mediated inflammatory diseases. In addition, BAFF induces class-switch DNA recombination to produce IgG, IgA and IgE (Litinskiy et al, 2002), which is in relation to Th2-mediated immune reaction-mediated allergic disorder such as asthma (Rackeman, 1947;Ostergaard, 1985;Corrigan, 2004). Our previous reports show that BAFF protein level was higher in asthma patient, suggesting that BAFF could be a novel diagnostic parameter and a novel therapeutic target to treat asthma (Kang et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

TACI:Fc scavenging B cell activating factor (BAFF) alleviates ovalbumin-induced bronchial asthma in mice

Moon

Ryu²

2007

Exp Mol Med

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Asthma was induced by the sensitization and challenge with ovalbumin (OVA) in mice. B-cell activating factor (BAFF) plays a role in mature B cell generation and maintenance. Here, we investigated whether, BAFF expression was changed in OVA-induced mice and whether the control of BAFF expression level alleviates the symptom of bronchial asthma. BAFF expression was detected in alveolar-associated cells surrounding bronchi of OVA-induced mouse lung tissues. BAFF protein was also increased in OVA-induced mouse serum. The increased BAFF transcripts was detected in OVA-induced mouse splenocytes. OVA-induced asthma was associated with the increased number of eosinophils in bronchoalveolar lavage fluid (BALF). When TACI:Fc scavenging soluble BAFF was injected to OVA-induced mice, a significant inhibition was detected in the thickness of airway smooth muscle and glycol-containing cellular elements in airway that were visualized by hematoxylin/eosin Y and periodic acid-Schiff staining, respectively. In addition, when mice were treated with TACI:Fc protein, BAFF protein level was decreased in alveolar-associated cells surrounding bronchi of OVA-induced mouse lung tissues compared to control mice. When compared to OVA-induced control, TACI:Fc treatment reduced the percentage of non-lymphoid cells and no changes were detected in lymphoid cell population. Hypodiploid cell formation in BALF was decreased by OVA-challenge but it was recovered by TACI:Fc treatment. Collectively, data suggest that asthmatic symptom could be alleviated by scavenging BAFF and then BAFF could be a novel target for the develpoment of anti-asthmatic agents.

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“…Regarding the mechanism of disease onset, asthma is classified into two types, atopic and nonatopic, based on the presence or absence of an IgE-mediated allergic reaction (1). Interestingly however, several recent reports show that asthma is almost always associated with some type of IgE-mediated allergic reaction (2,3).…”

Section: Introductionmentioning

confidence: 99%

A New Modified Classification of Bronchial Asthma Based on Clinical Symptoms.

et al. 1993

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The clinical features of four asthma types, Ia-1 (bronchospasm with 0-49ml/day of expectoration), Ia-2 (with 50-99 ml/day), Ib (over 100 ml/day), and II (bronchiolar obstruction), as classified by the clinical symptoms, were compared in 119 patients with bronchial asthma. The age of onset characteristic symptomsof each asthma type was in the 20's in types Ia-1 and Ia-2, in the 30's in type Ib, and in the 40's in type II patients. A significant increase in the number of neutrophils in bronchoalveolar lavage (BAL) fluid was found in type II patients. The proportion of BALeosinpphils was significantly higher in types Ia-2 and Ib asthma patients compared with that in type Ia-1 patients. The BAL eosinophil count was significantly higher in type Ib than in type Ia-2 patients. The FEV1.0%and %V25values were significantly lower in patients with type II asthma than in the patients with the other asthma types. Steroid-dependent intractable asthma (SDIA) was more often observed in patients with type Ib or type II asthma.

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NON‐IgE‐MEDIATED ASTHMA IN CHILDREN

Cited by 41 publications

References 9 publications

Elevation of total serum immunoglobulin E is associated with asthma in nonallergic individuals

Elevation of total serum immunoglobulin E is associated with asthma in nonallergic individuals

TACI:Fc scavenging B cell activating factor (BAFF) alleviates ovalbumin-induced bronchial asthma in mice

A New Modified Classification of Bronchial Asthma Based on Clinical Symptoms.

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