Non‐immune hydrops fetalis was rare in Sweden during 1997‐2015, but cases were associated with complications and poor prognosis

Whybra, Catharina; Källén, Karin; Hansson, Stefan R.; Gunnarsson, R

doi:10.1111/apa.15260

Cited by 18 publications

(30 citation statements)

References 26 publications

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“…3,32 The overall outcome for liveborn infants is poor, with the first-year survival rate at approximately 50%. 5,6,27,30,32 In our case, even if the hydrothorax was present between at least 21 and 26 gestational weeks, the newborn showed no respiratory complications and good perinatal outcomes. At the last medical control at 10 months of age, the infant still presented no cardiorespiratory disorders.…”

Section: Discussionmentioning

confidence: 45%

Section: Discussionmentioning

confidence: 99%

“… 3 , 32 The overall outcome for live‐born infants is poor, with the first‐year survival rate at approximately 50%. 5 , 6 , 27 , 30 , 32 …”

Section: Discussionmentioning

confidence: 99%

“…Due to difficulty in diagnosis and potential early spontaneous pregnancy termination, the incidence of hydrops fetalis varies considerably in different studies, ranging from 1.6 to 5.9 per 10,000 pregnancies. 5,6 Once a hydrops fetalis is diagnosed, clinicians should offer an attentive ultrasound examination searching for malformations, signs of fetal anemia, umbilical cord or placental irregularities, and cardiac functional abnormalities. In addition, genetics, serologic, and microbiologic examinations should be proposed.…”

Section: Discussionmentioning

confidence: 99%

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Spontaneous resolution of nonimmune hydrops fetalis in a fetus with TP63 gene mutation and LZTR1 gene variants

Hurni

Marangoni

Garofalo

et al. 2021

Clinical Case Reports

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Section: Discussionmentioning

confidence: 45%

Section: Discussionmentioning

confidence: 99%

“… 3 , 32 The overall outcome for live‐born infants is poor, with the first‐year survival rate at approximately 50%. 5 , 6 , 27 , 30 , 32 …”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Spontaneous resolution of nonimmune hydrops fetalis in a fetus with TP63 gene mutation and LZTR1 gene variants

Hurni

Marangoni

Garofalo

et al. 2021

Clinical Case Reports

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show abstract

“…These masses may obstruct venous return and complications such as fetal hydrops, which can cause fetal death in severe cases. Studies have shown that the survival rate of the fetus with edema is only 3% [ 5 ], and is associated with several obstetric complications, such as preterm delivery [ 6 ] and high stillbirth rate [ 7 ]. Therefore, carrying out the prediction and early diagnosis of the risk of developing fetal hydrops caused by CLM and implementing preventive interventions and treatment measures for high-risk groups are essential to reduce the incidence of fetal hydrops and improve the quality of prognosis of the child.…”

Section: Introductionmentioning

confidence: 99%

Diagnostic value of congenital pulmonary airway malformation volume ratio for fetal hydrops due to congenital lung malformations: a systematic review and meta-analysis

Zhu

Cheng

et al. 2022

Orphanet J Rare Dis

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Objective Meta-analysis was used to evaluate the diagnostic value of a CVR cut-off value of 1.6 for fetal hydrops due to congenital lung malformation (CLM). Methods A systematic search of PubMed, Embase, Web of Science, CNKI, VIP, and Wanfang published before 7/30/2021 for the value of a congenital pulmonary airway malformation volume ratio (CVR) cut-off value of 1.6 for the diagnosis of fetal hydrops. According to the inclusion and exclusion criteria, the literature that met the requirements were obtained. A total of 75 articles were retrieved, and 12 articles were included for further analysis. The quality of these studies was evaluated according to the Quality Assessment for Studies of Diagnostic Accuracy tool (QUADAS-2) criteria. The Q test and heterogeneity I2 were used to evaluate the heterogeneity due to non-threshold effects, and Stata 15.0 was used for statistical analysis to evaluate the diagnostic value of the CVR cutoff value of 1.6 for fetal hydrops due to CLM. Results A total of 12 studies were included. The QUADAS-2 indicated that the risk of bias was relatively low, and the clinical applicability was relatively high. Statistical analysis was performed on included studies using a random effect model. Meta-analysis showed that the pooled sensitivity, specificity, diagnostic ratio and summary receiver operating characteristic (SROC) for the diagnosis of fetal hydrops by CVR were 0.86 (95% CI, 0.72–0.93; I2 = 59.84), 0.90 (95% CI, 0.88–0.93; I2 = 31.94), 58 (95% CI, 22–149; I2 = 100%), 0.93 (95% CI, 0.91–0.95). Conclusions The sensitivity and specificity of CVR cut-off value 1.6 for the diagnosis of CLM-induced fetal hydrops were high, no publication bias was observed, and the CVR cut-off value 1.6 is meaningful for the early diagnosis prediction of CLM-induced fetal hydrops.

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Maternal outcomes of a cohort of pregnancies affected by non‐immune hydrops fetalis

Critchlow,

Wodoslawsky,

Makhamreh

et al. 2023

Intl J Gynecology & Obste

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ObjectiveTo describe the maternal outcomes of a prospective cohort of non‐immune hydrops fetalis (NIHF) pregnancies with negative standard‐of‐care evaluations.MethodsThis study was a secondary analysis of a prospective cohort study of NIHF pregnancies with negative work‐ups (infection, alloimmune anemia, fetomaternal hemorrhage, and chromosomal disorders). Outcomes were obstetric complications, including pre‐eclampsia, mirror syndrome, preterm birth, polyhydramnios, postpartum hemorrhage, and maternal mental health.ResultsForty pregnancies were included. Four patients developed pre‐eclampsia (4/40, 10.0%); three occurred postpartum. None was diagnosed with mirror syndrome. Of the 31 continued pregnancies, 16 (51.6%) resulted in early fetal death or stillbirth and 15 (48.4%) resulted in live births. Of the 15 live births, 8 (53.3%) were delivered by primary cesarean delivery; 5 (62.5%) were for hydrops fetalis. Eleven live births (73.3%) were delivered preterm; 9 (81.8%) were indicated, most commonly for fetal indications (7/9, 77.8%). Polyhydramnios occurred in 14/40 (35.0%) cases. Where EBL was recorded (n=37), there were 5 (13.5%) cases of postpartum hemorrhage and an additional 3 (8.1%) had uterine atony without hemorrhage. Eighteen patients (18/40, 45.0%) had new‐onset or exacerbated depression or anxiety symptoms.ConclusionOur study identified several important adverse outcomes of pregnancies complicated by NIHF with negative standard‐of‐care evaluations, including a high rate of postpartum pre‐eclampsia and worsened mental health. We identified a higher rate of cesarean delivery and preterm birth, both primarily for fetal indications. We also observed the known relationship between polyhydramnios, hemorrhage, and atony, but noted that this risk included pregnancies concluding in dilation and evacuation. Counseling after a diagnosis of NIHF should include these adverse outcomes.

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Non‐immune hydrops fetalis was rare in Sweden during 1997‐2015, but cases were associated with complications and poor prognosis

Cited by 18 publications

References 26 publications

Spontaneous resolution of nonimmune hydrops fetalis in a fetus with TP63 gene mutation and LZTR1 gene variants

Spontaneous resolution of nonimmune hydrops fetalis in a fetus with TP63 gene mutation and LZTR1 gene variants

Diagnostic value of congenital pulmonary airway malformation volume ratio for fetal hydrops due to congenital lung malformations: a systematic review and meta-analysis

Maternal outcomes of a cohort of pregnancies affected by non‐immune hydrops fetalis

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