I think endoscopic retrograde cholangiopancreatography (ERCP) is a very highly advanced upper endoscopic procedure, and is an uncomfortable procedure that requires adequate sedation for its successful conduction. But, The optimum method for sedation for endoscopic procedures is not known. Propofol has a faster recovery time than traditional sedative agents, but may be associated with increased complication rates. Dexmedetomidine is a highly selective α2 adrenoceptor agonist that has many advantages over other sedatives. In addition to producing sedative, analgesic, and anxiolytic effects, it provides respiratory stability. When patients are treated with appropriate analgesics, sedation with dexmedetomidine for ERCP would be safe and associated with better outcomes than sedation with other sedatives.