Non-insulin-based insulin resistance indexes in predicting severity for coronary artery disease

Wang, Ruiling; Fu, Xiangsheng; Song, Haiyan

doi:10.1186/s13098-022-00967-x

Cited by 40 publications

(40 citation statements)

References 40 publications

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“…In a prospective cohort study, IR measured by METS‐IR was associated with arterial stiffness and was a predictor of hypertensive events 38 . As a derivative of the TyG index, recent studies have found that TyG‐BMI is an independent risk factor for the prevalence of hypertension and that TyG‐BMI may predict the severity of coronary artery disease 39,40 . In addition, TyG‐BMI was associated with association between hyperuricemia, hepatic steatosis, and osteoporosis has also been confirmed in patients with type 2 diabetes 41–43 …”

Section: Discussionmentioning

confidence: 89%

Insulin resistance is associated with the presence and severity of retinopathy in patients with type 2 diabetes

Xu,

Pu,

Zhang

et al. 2023

Clinical Exper Ophthalmology

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BackgroundTo assess the relationship between novel insulin resistance (IR) indices and the presence and severity of diabetic retinopathy (DR) in patients with type 2 diabetes.MethodsThis is a cross‐sectional study involving 2211 patients. The study outcomes were DR events. The study exposures were IR indices including estimated glucose disposal rate (eGDR), natural logarithm of glucose disposal rate (lnGDR), metabolic insulin resistance score (METS‐IR), triglyceride glucose index‐body mass index (TyG‐BMI), triglyceride glucose index‐waist‐to‐hip ratio (TyG‐WHR), and triglyceride/high‐density lipoprotein cholesterol(TG/HDL‐c ratio). We used binary and multivariate ordered logistic regression models to estimate the association between different IR indices and the presence and severity of DR. Subject work characteristic curves were used to assess the predictive power of different IR indices for DR.ResultsDR was present in 25.4% of participants. After adjusting for all covariates, per standard deviation (SD) increases in eGDR (ratio [OR] 0.38 [95% CI 0.32–0.44]), lnGDR (0.34 [0.27–0.42]) were negatively associated with the presence of DR. In contrast, per SD increases in METS‐IR (1.97 [1.70–2.28]), TyG‐BMI (1.94 [1.68–2.25]), TyG‐WHR (2.34 [2.01–2.72]) and TG/HDL‐c ratio (1.21 [1.08–1.36]) were positively associated with the presence of DR. eGDR was strongly associated with severity of DR. Of all variables, eGDR had the strongest diagnostic value for DR (AUC = 0.757).ConclusionsOf the six IR indices, eGDR was significantly associated with the presence and severity of DR in patients with type 2 diabetes. eGDR has a good predictive value for DR. Thus, eGDR maybe a stronger marker of DR.

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Section: Discussionmentioning

confidence: 89%

Insulin resistance is associated with the presence and severity of retinopathy in patients with type 2 diabetes

Xu,

Pu,

Zhang

et al. 2023

Clinical Exper Ophthalmology

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“…Zhi et al elucidated a robust link between ischemic stroke and TyG-BMI and found that risk strati cation of ischemic stroke patients was improved using this index [12]. Yu et al reported that TyG-BMI is highly relevant to the severity of coronary artery disease [11]. However, another study involving 3,281 participants found that TyG-BMI was not useful in predicting incident hypertension [20].…”

Section: Discussionmentioning

confidence: 99%

“…The index simultaneously combines glucose, lipid levels and BMI, re ecting multiple critical factors in the management of PD. Recent studies have shown that TyG-BMI was associated with the risk of ischemic stroke, hypertension, and coronary artery disease [11][12][13]. However, its relationship with CVD mortality in the PD population remains unclear.…”

Section: Introductionmentioning

confidence: 99%

Triglyceride glucose-body mass index and cardiovascular mortality in patients undergoing peritoneal dialysis: A retrospective cohort study

Zhan

Peng

et al. 2023

Preprint

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Background: Recent studies have shown that triglyceride glucose-body mass index (TyG-BMI) is associated with the risk of ischemic stroke and coronary artery disease. However, little attention has been paid to the association between TyG-BMI and cardiovascular disease (CVD) mortality in patients undergoing peritoneal dialysis (PD). Therefore, this study aimed to explore the relationship between TyG-BMI and CVD mortality in Southern Chinese patients undergoing PD. Methods: Incident patients receiving PD during January 1, 2006, to December 31, 2018, with baseline serum triglycerides, glucose, and body mass index (BMI) information, were recruited for this single-center retrospective cohort study. TyG-BMI was calculated based on fasting plasma glucose, triglyceride, and BMI values. The association between TyG-BMI, CVD and all-cause mortality was evaluated using a multivariate-adjusted Cox proportional hazard regression model. Results: Of 2,335 patients, the mean age was 46.1±14.8 years; 1,382 (59.2%) were male, and 564 (24.2%) had diabetes. The median TyG-BMI was 183.7 (165.5–209.2). Multivariate linear regression showed that advanced age, male sex, history of CVD, higher levels of albumin and low-density lipoprotein cholesterol, and higher urine output were correlated with a higher TyG-BMI (P<0.05). During a median follow-up period of 46.6 (22.4–78.0) months, 615 patients died, of which 297 (48.2%) died as a result of CVD. After adjusting for demographics and comorbidities, TyG-BMI was significantly associated with an increased risk of CVD mortality (hazard ratio [HR] 1.51, 95% confidence interval [CI] 1.05–2.17) and all-cause mortality (HR 1.36, 95%CI 1.05–1.75). After full adjustment, 28% risk of CVD mortality (HR 1.28, 95%CI 1.13‒1.45) and 19% risk of all-cause mortality elevated (HR 1.19, 95%CI 1.09‒1.31) when TyG-BMI increased by 1-Stand Deviation (SD) (34.2). Conclusions: A higher baseline TyG-BMI was independently associated with an increased risk of CVD and all-cause mortality in patients receiving PD.

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“…Wang et al discovered that Mets-IR may have better discriminatory power than other IR indicators in predicting the incidence of coronary artery calci cation in asymptomatic adults without cardiovascular disease (CVD) [24]. Mets-IR is also a reliable predictor of coronary heart disease severity with an AUC of 0.726 (95% CI 0.677-0.775) [25]. A large longitudinal cohort study of Korean adults who were not diabetic found that higher Mets-IR levels were linked with an increased risk of new-onset ischemic heart disease (IHD) [26].…”

Section: Discussionmentioning

confidence: 99%

Mets-IR as a Predictor of Cardiovascular Events in the Middle-Aged and Elderly Population and Mediator role of blood lipids

Qian

Sheng

Shen

et al. 2023

Preprint

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Background: Worldwide, cardiovascular disease has a high morbidity and mortality rate, and the number of cardiovascular fatalities in China is rising yearly. Using fasting glucose, fasting triglycerides, body mass index (BMI), and high-density lipoprotein cholesterol (HDL-C), the metabolic score of insulin resistance (Mets-IR), a novel index created by Mexican researchers to assess insulin sensitivity, is a more precise way to measure insulin sensitivity. This study sought to determine the mediating function of triglycerides in the link between insulin resistance and cardiovascular disease, stroke, and cardiac issues in a Chinese population. Methods: The study's data came from the 2011 and 2018 China Health and Retirement Longitudinal Studies (CHARLS). We used three logistic regression models to account for the potential effects of ten factors on cardiovascular disease/stroke/heart disease (age, gender, marital status, education level, location, smoking status, drinking status, sleep duration, lipid level, blood glucose level, and past medical history). In order to determine the involvement of triglycerides (TG) in the link between Mets-IR and cardiovascular disease/stroke/heart disease events, we also conducted a mediation analysis using the R package "Mediation". Finally, we made an effort to fit Mets-IR into a logistic regression model to see if it has any more predictive power than already-established clinical risk factors. Results: This study comprised 4540 participants, of whom 494 (10.88%) were found to have cardiovascular disease (CVD). According to the data, participants with CVD had significantly higher triglyceride levels and baseline ages as well as shorter sleep duration. Moreover, the prevalence of CVD was greater in men than in women (p=0.03). The last Mets-IR quartile (Q4) had the highest risk of new-onset cardiovascular disease, according to analysis using Mets-IR as a continuous variable (OR=1.81, 95CI=1.37-2.38) and there was a linear dose-response relationship between Mets-IR and the risk of new-onset cardiovascular disease, stroke, and heart issues (Poverall<0.05, Pnon-linear>0.05). No significant interactions between socioeconomic traits and medical history and Mets-IR were revealed by stratified analysis. Approximately 2.5% and 3.5% (indirect effect/total effect) of the significant correlations of Mets-IR with cardiovascular events and stroke were mediated by TG, respectively. With the addition of Mets-IR to the base model, the continuous NRI and IDI for predicting cardiovascular disease increased by 0.175 (P <0.001) and 0.006 (P <0.001), respectively, showing a significant improvement in the incremental prediction analysis of Mets-IR. Conclusion: Mets-IR is linked to an increased risk of cardiovascular disease/stroke/cardiac issues, and TG mediates these connections. Improving insulin sensitivity and lipid regulation may be essential and effective preventive measures for cardiovascular events.

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Non-insulin-based insulin resistance indexes in predicting severity for coronary artery disease

Cited by 40 publications

References 40 publications

Insulin resistance is associated with the presence and severity of retinopathy in patients with type 2 diabetes

Insulin resistance is associated with the presence and severity of retinopathy in patients with type 2 diabetes

Triglyceride glucose-body mass index and cardiovascular mortality in patients undergoing peritoneal dialysis: A retrospective cohort study

Mets-IR as a Predictor of Cardiovascular Events in the Middle-Aged and Elderly Population and Mediator role of blood lipids

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