Non-Intestinal Bacterial Infections

Isaäcson, M; Hale, Michael

doi:10.1007/978-3-642-57863-2_6

Tropical Pathology

1995

DOI: 10.1007/978-3-642-57863-2_6

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Non-Intestinal Bacterial Infections

M Isaäcson¹,

Michael Hale²

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1996

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“…Another important African plague focus is Ovamboland in northern Namibia (18). The overall case fatality rate from plague is about 10%, although it was higher (15%) among patients with reported cases of the disease in Africa between 1976 and 1990 (10). In view of the high mortality rate among individuals with untreated plague, effective antibiotic treatment is mandatory (4).…”

mentioning

confidence: 99%

In vitro activities of 14 antibiotics against 100 human isolates of Yersinia pestis from a southern African plague focus

Frean

Arntzen

Capper

et al. 1996

Antimicrob Agents Chemother

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A limited repertoire of antimicrobial agents is currently in use for the treatment of plague. We investigated the in vitro activities of some newer antimicrobial agents against Yersinia pestis. Among the injectable agents tested, cefotaxime was the most active, and among the oral agents, both levofloxacin and ofloxacin were highly active, with MICs at which 90% of isolates are inhibited of <0.03 g/ml. The susceptibilities to the ketolide RU004 and the penem faropenem warrant attention. The enhanced activities of quinolones against Y. pestis suggest that these agents should be further investigated for the treatment of human plague in the future.

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mentioning

confidence: 99%

In vitro activities of 14 antibiotics against 100 human isolates of Yersinia pestis from a southern African plague focus

Frean

Arntzen

Capper

et al. 1996

Antimicrob Agents Chemother

View full text Add to dashboard Cite

show abstract

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Non-Intestinal Bacterial Infections

Cited by 1 publication

References 73 publications

In vitro activities of 14 antibiotics against 100 human isolates of Yersinia pestis from a southern African plague focus

In vitro activities of 14 antibiotics against 100 human isolates of Yersinia pestis from a southern African plague focus

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