Non-intrusive optical study of gas and its exchange in human maxillary sinuses

Abstract

Non-intrusive optical study of gas and its exchange in human maxillary sinuses -art. no. 662804Persson, Linda; Andersson, Mats; Svensson, Tomas; Lewander, Märta; Svanberg, Katarina; Svanberg, Sune Lewander, M., Svanberg, K., & Svanberg, S. (2007). Non-intrusive optical study of gas and its exchange in human maxillary sinuses -art. no. 662804. In Diagnostic Optical Spectroscopy in Biomedicine IV (Vol. 6628, pp. 62804-62804). SPIE. DOI: 10.1117/12.728120 General rights Copyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights.• Users may download and print one copy of any publication from the public portal for the purpose of private study or research.• You may not further distribute the material or use it for any profit-making activity or commercial gain • You may freely distribute the URL identifying the publication in the public portal Volunteers have been investigated by injecting near-infrared light fibre-optically in contact with the palate inside the mouth. The multiply scattered light was detected externally by a handheld probe on and around the cheek bone. A significant signal difference in oxygen imprint was observed when comparing volunteers with widely different anamnesis regarding maxillary sinus status. Control measurements through the hand and through the cheek below the cheekbone were also performed to investigate any possible oxygen offset in the setup. These provided a consistently non-detectable signal level. The passages between the nasal cavity and the maxillary sinuses were also non-intrusively optically studied, to the best of our knowledge for the first time. These measurements provide information on the channel conductivity which may prove useful in facial sinus diagnostics.The results suggest that a clinical trial together with an ear-nose-throat (ENT) clinic should be carried out to investigate the clinical use of the new technique.

Simultaneous detection of molecular oxygen and water vapor in the tissue optical window using tunable diode laser spectroscopy

“…The cavities located within the human skull are surrounded by strongly scattering tissue, and gas signal recordings for such cavities have been previously demonstrated with laboratory equipment [11,12]. However, then separate setups were used for Fig.…”

“…The diffusely scattered light emerging out through the cheek bone with a fraction crossing the maxillary sinus is detected by placing the detector on the cheek bone [11,12].…”

Gas monitoring in human sinuses using tunable diode laser spectroscopy

“…No such behavior could be observed on a volunteer with constantly recurring sinus problems. 9 We demonstrate molecular oxygen measurements on maxillary sinuses for 11 healthy volunteers using the transmission detection geometry discussed. The measured values have been compared with values obtained using Monte Carlo simulations of a model representing the maxillary sinuses.…”

“…The present study extends and establishes the methodology, which was first described in two recent exploratory papers. 8,9 The new development became possible by taking advantage of optical spectroscopic techniques refined in the environmental monitoring of free gas, and an understanding of tissue optics, developed for purposes such as optical mammography and photodynamic therapy dosimetry ͑e.g., Ref.…”

Clinical system for non-invasive in situ monitoring of gases in the human paranasal sinuses

“…Current diagnostic methods of the paranasal sinuses include case history and, in selected cases, computed tomography (CT) [16]. The diagnostic potential of the GASMAS technique has been demonstrated on volunteers with a laboratory system for oxygen spectroscopy [17,8]. As discussed in Ref.…”