Non-invasive assessment determine the swallowing and respiration dysfunction in early Parkinson's disease

Wang, Chin-Man; Weng, Yi-Hsin; Hsu, Yi-Hsuan; Wu, Yih‐Ru

doi:10.1016/j.parkreldis.2017.05.024

Cited by 36 publications

(39 citation statements)

References 28 publications

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“…Although there have been numerous studies of pulmonary function in PD, few have investigated the contributions of central and peripheral respiratory mechanisms using functional respiratory testing in patients with dyspnea. Table summarizes the key studies addressing pulmonary dysfunction in PD and shows the frequency of restrictive and obstructive patterns . Review of these studies shows a lack of consistent findings, which is likely due to the fact that they included diverse cohorts of patients at different stages of disease and used variable outcome measures.…”

Section: Studies Of Pulmonary Function In Pdmentioning

confidence: 99%

“…Table 1 summarizes the key studies addressing pulmonary dysfunction in PD and shows the frequency of restrictive and obstructive patterns. 4,17,[22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37] Review of these studies shows a lack of consistent findings, which is likely due to the fact that they included diverse cohorts of patients at different stages of disease and used variable outcome measures. However, a restrictive pattern of pulmonary dysfunction has been a consistent finding, reported in up to 94% of cases in different studies.…”

Section: Studies Of Pulmonary Function In Pdmentioning

confidence: 99%

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Brainstem Ventilatory Dysfunction: A Plausible Mechanism for Dyspnea in Parkinson's Disease?

et al. 2020

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Dyspnea is an under‐recognized and debilitating symptom that is reported in up to 40% of patients with Parkinson's disease and may have multiple origins. Despite its frequency, it is poorly researched, and there is a general lack of understanding of the pathophysiology of dyspnea and respiratory dysfunction in PD. Consequently, a number of PD patients are labelled as having “unexplained dyspnea.” Studies to date have focused mainly on evaluating ventilatory capacity and lung volumes, and little is known about the effects of the disease on the medullary and pontine ventilatory control centers within the brainstem. This is of particular relevance in view of neuropathological studies demonstrating early involvement of the dorsal medulla and other brainstem structures by the disease process. The possibility that impaired brainstem ventilatory control is a contributory mechanism for dyspnea and could be a premotor manifestation in some PD patients therefore warrants further attention. This review focuses on clinical, pathological, and experimental evidence for the involvement of brainstem respiratory centers in PD. We highlight the need for further research, particularly in PD patients with unexplained dyspnea. © 2020 International Parkinson and Movement Disorder Society

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Section: Studies Of Pulmonary Function In Pdmentioning

confidence: 99%

Section: Studies Of Pulmonary Function In Pdmentioning

confidence: 99%

Brainstem Ventilatory Dysfunction: A Plausible Mechanism for Dyspnea in Parkinson's Disease?

et al. 2020

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“…Similar to our previous studies ( 25 – 28 ), we used an electrophysiological monitoring system (Biopac MP 100 system) and AcqKnowledge software for data recording and analysis. By using the Biopac 100 system, we simultaneously recorded swallowing and respiration biosignals, including submental surface electromyography (sEMG), nasal airflow, and thyroid cartilage excursion, during swallowing.…”

Section: Methodsmentioning

confidence: 99%

“…All the aforementioned parameters have been defined and used to analyze swallowing and its coordination with respiration in our previous studies ( 25 – 28 ).…”

Section: Methodsmentioning

confidence: 99%

“…Previous studies have reported swallowing and respiratory dysfunction in PD ( 22 – 25 ), but no longitudinal follow-up study has evaluated the therapeutic effect of RST on swallowing function and respiration coordination in PD. We hypothesized that a home-based OLE program including effortful dry (saliva) swallowing and lingual exercises can improve the coordination of swallowing and respiration.…”

Section: Introductionmentioning

confidence: 99%

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Home-Based Orolingual Exercise Improves the Coordination of Swallowing and Respiration in Early Parkinson Disease: A Quasi-Experimental Before-and-After Exercise Program Study

Wang

et al. 2018

Front. Neurol.

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Introduction: The coordination of swallowing and respiration is important for safety swallowing without aspiration. This coordination was affected in Parkinson disease (PD). A noninvasive assessment tool was used to investigate the effect of an easy-to-perform and device-free home-based orolingual exercise (OLE) program on swallowing and respiration coordination in patients with early-stage PD.Materials and Methods: This study had a quasi-experimental before-and-after exercise program design. Twenty six patients with early-stage PD who were aged 62.12 ± 8.52 years completed a 12-week home-based OLE program. A noninvasive assessment tool was used to evaluate swallowing and respiration. For each patient, we recorded and analyzed 15 swallows (3 repeats of 5 water boluses: 1, 3, 5, 10, and 20 mL) before and after the home-based OLE program. Oropharyngeal swallowing and its coordination with respiration were the outcome measures. The frequency of piecemeal deglutition, pre- and post-swallowing respiratory phase patterns, and parameters of oropharyngeal swallowing and respiratory signals (swallowing respiratory pause [SRP], onset latency [OL], total excursion time [TET], excursion time [ET], second deflexion, amplitude, and duration of submental sEMG activity, and amplitude of laryngeal excursion) were examined.Results: The rate of piecemeal deglutition decreased significantly when swallowing 10- and 20-mL water boluses after the program. In the 1-mL water bolus swallowing trial, the rate of protective pre- and post-swallowing respiratory phase patterns was significantly higher after the program. For the parameters of oropharyngeal swallowing and respiratory signals, only the amplitude of laryngeal excursion was significantly lower after the program. Moreover, the volume of the water bolus significantly affected the SRP and duration of submental sEMG when patients swallowed three small water bolus volumes (1, 3, and 5 mL).Conclusion: The home-based OLE program improved swallowing and its coordination with respiration in patients with early-stage PD, as revealed using a noninvasive method. This OLE program can serve as a home-based program to improve swallowing and respiration coordination in patients with early-stage PD.

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A Review of the Use of Prosodic Aspects of Speech for the Automatic Detection and Assessment of Parkinson’s Disease

Moro-Velázquez

Dehak

2020

Communications in Computer and Information Science

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Non-invasive assessment determine the swallowing and respiration dysfunction in early Parkinson's disease

Cited by 36 publications

References 28 publications

Brainstem Ventilatory Dysfunction: A Plausible Mechanism for Dyspnea in Parkinson's Disease?

Brainstem Ventilatory Dysfunction: A Plausible Mechanism for Dyspnea in Parkinson's Disease?

Home-Based Orolingual Exercise Improves the Coordination of Swallowing and Respiration in Early Parkinson Disease: A Quasi-Experimental Before-and-After Exercise Program Study

A Review of the Use of Prosodic Aspects of Speech for the Automatic Detection and Assessment of Parkinson’s Disease

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