“…Is necessary to determine the total lymph node burden by ALND and provide a reference for systematic treatment? Research results have shown that [ 3 , [65] , [66] , [67] ], the proportion of 1–2 positive SLN patients with total over three ALNs metastasis after receiving ALND is 5.7–18.9 %, indicating that more than 80 % of these patients have a lower risk of non-SLNM because the number of metastatic ALNs is ≤ 3. In the RxPONDER study, the axillary management of patients with 1–2 positive SLN was determined by a physician, and ALND was not required.…”