Non-invasive assessment of oxidative stress in preterm infants

Peña-Bautista, Carmen; Durand, Thierry; Vigor, Claire; Oger, Camille; Galano, Jean‐Marie; Cháfer-Pericás, Consuelo

doi:10.1016/j.freeradbiomed.2019.02.019

Cited by 31 publications

(31 citation statements)

References 86 publications

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“…Moreover, it could be acquired without any discomfort in comparison to blood or cerebrospinal fluid (CSF) collection [27]. Therefore, biomarkers from saliva might be easily gained, especially in small children and even newborn [36]. The samples can be even self-collected by the patients at home or with the help of a caregiver, and easily store in the refrigerator until diagnostics [37].…”

Section: Saliva: Composition and Diagnostic Importancementioning

confidence: 99%

Salivary Redox Biomarkers in Selected Neurodegenerative Diseases

Maciejczyk

Gerreth

2020

JCM

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Neurodegenerative diseases (NDDs), such as Alzheimer’s disease, Parkinson’s disease, and Huntington’s disease, are disorders, which cause irreversible and progressive deterioration of the central nervous system. The pathophysiology of NDDs is still not fully explained; nevertheless, oxidative stress is considered as a critical mediator of cerebral degeneration, brain inflammation, as well as neuronal apoptosis. Therefore, it is not surprising that redox biomarkers are increasingly used in the diagnosis of neurodegenerative diseases. As saliva is a very easy to obtain bioliquid, it seems promising to use this biomaterial in the diagnosis of NDDs. Saliva collection is easy, cheap, stress-free, and non-infectious, and it does not require the help of a specialised medical personnel. Additionally, the concentrations of many salivary redox biomarkers correlate with their content in blood serum as well as the degree of disease progression, which makes them non-invasive indicators of NDDs. This paper reviews the latest knowledge concerning the use of salivary redox biomarkers in the diagnosis and prognosis of selected neurodegenerative diseases.

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Section: Saliva: Composition and Diagnostic Importancementioning

confidence: 99%

Salivary Redox Biomarkers in Selected Neurodegenerative Diseases

Maciejczyk

Gerreth

2020

JCM

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“…Most complications are related to the dysfunction of immature organ systems. In some cases, complications resolve entirely; in others, residual organ dysfunction remains [5,6]. The most common complications in extremely preterm infants are cardiac (patent ductus arteriosus (PDA)), neurological (poor sucking and swallowing reflexes, apneic episodes, IVH, developmental or cognitive delays), ocular (ROP, myopia and/or strabismus), gastrointestinal (feeding intolerance, with increased risk of aspiration, NEC), renal (metabolic acidosis, growth failure), infective (sepsis, meningitis), respiratory (respiratory distress syndrome, respiratory insufficiency of prematurity, chronic lung disease and BPD), and metabolic (hypoglycemia, hyperbilirubinemia, and metabolic bone disease-osteopenia of prematurity) [7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Oxidative Stress in Preterm Infants: Overview of Current Evidence and Future Prospects

et al. 2020

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Preterm birth (PTB), defined as parturition prior to 37 weeks of gestation, is the leading cause of morbidity and mortality in the neonatal population. The incidence and severity of complications of prematurity increase with decreasing gestational age and birthweight. The aim of this review study is to select the most current evidence on the role of oxidative stress in the onset of preterm complication prevention strategies and treatment options with pre-clinical and clinical trials. We also provide a literature review of primary and secondary studies on the role of oxidative stress in preterm infants and its eventual treatment in prematurity diseases. We conducted a systematic literature search of the Medline (Pubmed), Scholar, and ClinicalTrials.gov databases, retroactively, over a 7-year period. From an initial 777 articles identified, 25 articles were identified that met the inclusion and exclusion criteria. Of these, there were 11 literature reviews: one prospective cohort study, one experimental study, three case-control studies, three pre-clinical trials, and six clinical trials. Several biomarkers were identified as particularly promising, such as the products of the peroxidation of polyunsaturated fatty acids, those of the oxidation of phenylalanine, and the hydroxyl radicals that can attack the DNA chain. Among the most promising drugs, there are those for the prevention of neurological damage, such as melatonin, retinoid lactoferrin, and vitamin E. The microbiome also has an important role in oxidative stress. In conclusion, the most recent studies show that a strong relationship between oxidative stress and prematurity exists and that, unfortunately, there is still little therapeutic evidence reported in the literature.

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“…Prematurity is the leading cause of death among newborns and it comes in second among children below five years old, after pneumonia and, at the same time, prematurity increases the risk of serious lifetime disabilities [1,2]. Extremely and very preterm infants are a special cohort of newborns with their inherent functional immaturity and specific pathological conditions which are accompanied by hypoxia, reoxygenation, tissue hypoperfusion, increased risk of oxidative stress [3,4].…”

Section: Introductionmentioning

confidence: 99%

Predictors of adverse outcomes in preterm infants in the early neonatal period

Кліщ

Pavlyshyn

Kozak

et al. 2020

J Educ Health Sport

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Introduction. Extremely and very preterm infants are a special cohort of newborns with inherent functional immaturity and specific pathological conditions which are accompanied by hypoxia, reoxygenation, tissue hypoperfusion, increased risk of oxidative stress. Premature infants are prone to oxidative deterioration which plays a key role in the pathogenesis of severe diseases such as respiratory distress syndrome, necrotizing enterocolitis, periventricular leukomalacia, patent ductus arteriosus, bronchopulmonary dysplasia, and retinopathy of prematurity. 365Objective. The aim of the research was to estimate the predictors of adverse outcomes in preterm infants with gestational age less than 32 weeks in the early neonatal period by assessment of oxidative stress markers. Material and methods.A total amount of 46 preterm infants with gestational age less than 32 weeks in the early neonatal period were included in the research. According to the results of early outcomes newborns were divided into two groups: I group -12 infants with adverse outcomes and II group -34 preterm infants with favorable outcomes. Twenty healthy newborns were included in the control group (III group). Clinical examination of infants and laboratory determination of oxidative stress markers were done for all participants.Results. Asphyxia, early onset sepsis, intraventricular hemorrhage in preterm infants less than 32 weeks of gestation had increased the risk of mortality in the early neonatal period. The level of 8-isoprostane, ROS, TBP, LHP was significantly higher in neonates with adverse outcomes (group I). It was found that the level of 8-isoprostane more than 595.4 mg/ml, ROS level above 0.483 IU, TBP higher than 5.14 μmol/l and LHP levels above 5.91 U/m were associated with unfavorable outcomes in the early neonatal period. Decreased activity of the antioxidant system (catalase, SOD) increases the risk of early neonatal mortality.Conclusions. The activation of oxidative stress in preterm infants may be a predictor of adverse outcomes in the early neonatal period.

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Non-invasive assessment of oxidative stress in preterm infants

Cited by 31 publications

References 86 publications

Salivary Redox Biomarkers in Selected Neurodegenerative Diseases

Salivary Redox Biomarkers in Selected Neurodegenerative Diseases

Oxidative Stress in Preterm Infants: Overview of Current Evidence and Future Prospects

Predictors of adverse outcomes in preterm infants in the early neonatal period

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