Non-invasive brain stimulation as therapeutic approach for ischemic stroke: Insights into the (sub)cellular mechanisms

Kemps, Hannelore; Gervois, Pascal; Brône, Bert; Lemmens, Robin; Bronckaers, Annelies

doi:10.1016/j.pharmthera.2022.108160

Cited by 16 publications

(10 citation statements)

References 141 publications

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“…In addition, tDCS is more likely to be used in double-blind or sham-controlled studies. 31 , 32 Most of the current comparisons of efficacy are derived from reviews between the two, and no direct guidelines have reported recommendations related to the use of post-stroke dysfunction. One study has demonstrated the effectiveness of low-frequency TMS combined with anodal tDCS stimulation protocols in motor recovery in subacute stroke patients.…”

Section: Discussionmentioning

confidence: 99%

Research Hotspots and Global Trends of Transcranial Direct Current Stimulation in Stroke: A Bibliometric Analysis

Zhou¹,

Zhou²,

Zeng³

et al. 2023

NDT

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Purpose Transcranial direct current stimulation has been widely used in the clinical treatment of stroke. The purpose of this study was to perform a bibliometric analysis of scientific literature in this field. Methods Articles and reviews regarding transcranial direct current stimulation in stroke from January 01, 2004 to May 31, 2022 were identified from the Science Citation Index-Expanded of the Web of Science Core Collection database. CiteSpace 6.1.R2, Bibliometrix and the Bibliometric Online Analysis Platform were used to analyze data. Results A total of 905 papers were obtained, with the highest number of publications coming from the USA. The institutions and authors with the most publications were Harvard Medical School and Fregni F respectively. Nitsche MA had the most co-citations, followed by Fregni F. Neurosciences was the most fruitful research area and Brain Stimulation had the highest H-index. The research topics could be divided into three sections: mechanisms of treatment, comparison of efficacy with transcranial magnetic stimulation, clinical application of post-stroke dysfunction. The field of “walking”, “strength” and “virtual reality therapy” are the future research hotspots of transcranial direct current stimulation. Conclusion The overall research showed a slow growth trend, and the outstanding contribution of the USA in this field cannot be ignored. Relevant researchers are suggested to focus on international collaboration and actively conduct high-quality randomized controlled clinical trials on research hotspots and frontiers in order to identify the optimal stimulation paradigm for clinical purposes.

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Section: Discussionmentioning

confidence: 99%

Research Hotspots and Global Trends of Transcranial Direct Current Stimulation in Stroke: A Bibliometric Analysis

Zhou¹,

Zhou²,

Zeng³

et al. 2023

NDT

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“…14 For tDCS, cathodal stimulation reduces cortical excitability while anodal stimulation increases cortical excitability. 15 NIBS therapy offers safe, effective and non-invasive approaches to promote functional recovery in stroke survivors. 15 Moreover, both tDCS and rTMS have shown promising outcomes in treating PSD.…”

Section: Introductionmentioning

confidence: 99%

“…15 NIBS therapy offers safe, effective and non-invasive approaches to promote functional recovery in stroke survivors. 15 Moreover, both tDCS and rTMS have shown promising outcomes in treating PSD.…”

Section: Introductionmentioning

confidence: 99%

“…With rTMS, low‐frequency (LF) rTMS (≤1 Hz) reduces cortical excitability, while high‐frequency (HF) rTMS (≥5 Hz) increases cortical excitability 14 . For tDCS, cathodal stimulation reduces cortical excitability while anodal stimulation increases cortical excitability 15 . NIBS therapy offers safe, effective and non‐invasive approaches to promote functional recovery in stroke survivors 15 .…”

Section: Introductionmentioning

confidence: 99%

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Non‐invasive brain stimulation for treating post‐stroke depression: A network meta‐analysis

Sun

Liu

et al. 2023

Int J Geriat Psychiatry

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Objective: To compare the antidepressant effects and tolerability of repetitive transcranial magnetic stimulation (rTMS) and transcranial direct current stimulation (tDCS) treatments in patients with post-stroke depression (PSD). Methods:We included randomized controlled trials comparing active stimulation with sham stimulation. Primary outcomes were the depression score after treatment, presented as standardized mean differences with 95% confidence intervals.Response/remission and long-term antidepressant efficacy were also examined. We estimated effect-size using pairwise and Bayesian network meta-analysis (NMA) with random-effects model. Results:We identified 33 studies (total n = 1793). In NMA, 5 of 6 treatment strategies were associated with higher effect compared with sham therapy: dual rTMS (standardized mean differences = −1.5; 95% confidence interval = −2.5 to −0.57), dual LFrTMS (−1.5, −2.4 to −0.61), dual tDCS (−1.1, −1.5 to −0.62), HFrTMS (−1.1, −1.3 to −0.85) and LFrTMS (−0.90, −1.2 to −0.6). And dual rTMS, dual LFrTMS or HFrTMS may be more effective than other interventions for achieving antidepressant effects. Regarding secondary outcomes, rTMS can promote depression remission and response, and alleviate depression for at least 1 month. rTMS and tDCS were well tolerated. Conclusions: Bilateral rTMS and HFrTMS are considered top-priority non-invasive brain stimulation (NIBS) interventions for improving PSD. Dual tDCS and LFrTMS are also efficient.

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“…In tDCS models, both anodal and cathodal stimulation can improve post‐stroke functional recovery by modulating neurogenesis, increasing oligodendrocyte precursor recruitment, and polarizing microglia 23 . Although most preclinical research has demonstrated the neuroprotective benefits of NIBS in acute stroke models, 24 rTMS can also improve functional recovery in chronic stroke models, which relate more closely to CP pathologies 25 . Preclinical tDCS findings report beneficial effects on cortical neuronal cell viability and functional recovery in subacute stroke models 26 .…”

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confidence: 99%

Safety and efficacy of non‐invasive brain stimulation for the upper extremities in children with cerebral palsy: A systematic review

Metelski,

Gu,

Quinn

et al. 2023

Develop Med Child Neuro

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AimTo evaluate available evidence examining safety and efficacy of non‐invasive brain stimulation (NIBS) on upper extremity outcomes in children with cerebral palsy (CP).MethodWe electronically searched 12 sources up to May 2023 using JBI and Cochrane guidelines. Two reviewers selected articles with predetermined eligibility criteria, conducted data extraction, and assessed risk of bias using the Cochrane Risk of Bias criteria.ResultsNineteen studies were included: eight using repetitive transcranial magnetic stimulation (rTMS) and 11 using transcranial direct current stimulation (tDCS). Moderate certainty evidence supports the safety of rTMS and tDCS for children with CP. Very low to moderate certainty evidence suggests that rTMS and tDCS result in little to no difference in upper extremity outcomes.InterpretationEvidence indicates that NIBS is a safe and feasible intervention to target upper extremity outcomes in children with CP, although it also indicates little to no significant impact on upper extremity outcomes. These findings are discussed in relation to the heterogeneous participants’ characteristics and stimulation parameters. Larger studies of high methodological quality are required to inform future research and protocols for NIBS.

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Non-invasive brain stimulation as therapeutic approach for ischemic stroke: Insights into the (sub)cellular mechanisms

Cited by 16 publications

References 141 publications

Research Hotspots and Global Trends of Transcranial Direct Current Stimulation in Stroke: A Bibliometric Analysis

Research Hotspots and Global Trends of Transcranial Direct Current Stimulation in Stroke: A Bibliometric Analysis

Non‐invasive brain stimulation for treating post‐stroke depression: A network meta‐analysis

Safety and efficacy of non‐invasive brain stimulation for the upper extremities in children with cerebral palsy: A systematic review

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