Non-invasive Brain Stimulation for the Treatment of Nicotine Addiction: Potential and Challenges

Yang, Lizhuang; Yang, Zhiyu; Zhang, Xiaochu

doi:10.1007/s12264-016-0056-3

Cited by 15 publications

(9 citation statements)

References 65 publications

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“…40 Non-invasively, stimulation of the brain using transcranial magnetic stimulation may also be effective by generating a brief, high-intensity electric shock between two electrodes placed on the scalp. 41,42…”

Section: Discussionmentioning

confidence: 99%

Immediate and Sustained Decrease in Smoking Urges After Acute Insular Cortex Damage

Abdolahi

Williams

Benesch

et al. 2017

Nicotine &Amp; Tobacco Research

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Human lesioning studies that evaluate the insula's involvement in maintaining nicotine addiction make inferences of the insula's role in decreasing urge, but do not use validated instruments that directly assess urges. This study corroborates prior findings using the continuous Questionnaire of Smoking Urges to quantify changes in urge from before lesion onset to immediate and 3-month follow-up time points.

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Section: Discussionmentioning

confidence: 99%

Immediate and Sustained Decrease in Smoking Urges After Acute Insular Cortex Damage

Abdolahi

Williams

Benesch

et al. 2017

Nicotine &Amp; Tobacco Research

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“…Although there are various ways to modulate the activity of a specific brain area, such as random noise stimulation, ultrasound stimulation, electoral stimulation, and magnetic stimulation, recent research has been focusing on the latter two [76,77]. Transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS) are two of the best-studied approaches for treating drug addiction and other mental disorders [76][77][78][79]. Studies have shown that stimulating dorsal lateral PFC by TMS and tDCS were effective to reduce craving, improve cognition, and ameliorate the mood states in subjects using major drugs of abuse [76,80].…”

Section: Brain Stimulationmentioning

confidence: 99%

Drug addiction: a curable mental disorder?

Liu

2018

Acta Pharmacol Sin

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Drug addiction is a chronic, relapsing brain disorder. Multiple neural networks in the brain including the reward system (e.g., the mesocorticolimbic system), the anti-reward/stress system (e.g., the extended amygdala), and the central immune system, are involved in the development of drug addiction and relapse after withdrawal from drugs of abuse. Preclinical and clinical studies have demonstrated that it is promising to control drug addiction by pharmacologically targeting the addiction-related systems in the brain. Here we review the pharmacological targets within the dopamine system, glutamate system, trace amine system, antireward system, and central immune system, which are of clinical interests. Furthermore, we discuss other potential therapies, e.g., brain stimulation, behavioral treatments, and therapeutic gene modulation, which could be effective to treat drug addiction. We conclude that, although drug addiction is a complex disorder that involves complicated neural mechanisms and psychological processes, this mental disorder is treatable and may be curable by therapies such as gene modulation in the future.

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“…The accepted way to target ES precisely to a specific area within the brain or body is by invasive techniques with inserted or implanted electrodes. Tissue damage, pain, risks of bleeding, infection, and inflammation associated with electrode placement preclude the use of invasive techniques for routine examination of patients, disease diagnostics, and for treatments which do not justify implantation surgery (such as outpatient treatment of drug addiction by brain stimulation 15–17 ).…”

Section: Introductionmentioning

confidence: 99%

Selective distant electrostimulation by synchronized bipolar nanosecond pulses

Gianulis

Casciola

Zhou

et al. 2019

Sci Rep

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A unique aspect of electrostimulation (ES) with nanosecond electric pulses (nsEP) is the inhibition of effects when the polarity is reversed. This bipolar cancellation feature makes bipolar nsEP less efficient at biostimulation than unipolar nsEP. We propose to minimize stimulation near pulse-delivering electrodes by applying bipolar nsEP, whereas the superposition of two phase-shifted bipolar nsEP from two independent sources yields a biologically-effective unipolar pulse remotely. This is accomplished by electrical compensation of all nsEP phases except the first one, resulting in the restoration of stimulation efficiency due to cancellation of bipolar cancellation (CANCAN-ES). We experimentally proved the CANCAN-ES paradigm by measuring YO-PRO-1 dye uptake in CHO-K1 cells which were permeabilized by multiphasic nsEP (600 ns per phase) from two generators; these nsEP were synchronized either to overlap into a unipolar pulse remotely from electrodes (CANCAN), or not to overlap (control). Enhancement of YO-PRO-1 entry due to CANCAN was observed in all sets of experiments and reached ~3-fold in the center of the gap between electrodes, exactly where the unipolar pulse was formed, and equaled the degree of bipolar cancellation. CANCAN-ES is promising for non-invasive deep tissue stimulation, either alone or combined with other remote stimulation techniques to improve targeting.

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Non-invasive Brain Stimulation for the Treatment of Nicotine Addiction: Potential and Challenges

Cited by 15 publications

References 65 publications

Immediate and Sustained Decrease in Smoking Urges After Acute Insular Cortex Damage

Immediate and Sustained Decrease in Smoking Urges After Acute Insular Cortex Damage

Drug addiction: a curable mental disorder?

Selective distant electrostimulation by synchronized bipolar nanosecond pulses

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