Non-Invasive Characterization of Atrial Activity Immediately Prior to Termination of Paroxysmal Atrial Fibrillation

Alcaraz, Raúl; Rieta, J.J.; Hornero, Fernando

doi:10.1016/s1885-5857(08)60091-2

Cited by 9 publications

(12 citation statements)

References 41 publications

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“…Whether AF spontaneous termination is preceded by a progressive fusion of wavelets or involves a simultaneous block of all wavelets present in the tissue remains an open question, and past results were mixed. Several studies revealed organization preceding spontaneous terminations [2,15], while other studies did not [20]. No consensus was found about the appropriate time scale of AF spontaneous termination, ranging from several minutes [2] to 1 s [16].…”

Section: Discussionmentioning

confidence: 99%

“…In a study based on intra-atrial recordings in humans, observations failed to show any change in number of wavelets or cycle length before spontaneous AF termination, therefore supporting, but not proving, the hypothesis that AF wavelets are simultaneously annihilated [20]. On the other hand, several studies demonstrated that AF global organization or cycle length tended to increase prior to termination, suggesting a process of wavelet fusion [2,15]. In a mapping study, spontaneous AF termination was found to be polymorphic with spatially heterogeneous groups of unstable rhythms and different dynamical behaviors were observed in the right atrium (RA) and the left atrium (LA) [15].…”

Section: Introductionmentioning

confidence: 96%

“…A study in patients with paroxysmal AF reported that changes in the organization of electrocardiographic signals could be detected up to 1 min prior to AF termination [2]. Another study in paroxysmal AF patients found that changes in the power spectrum of the surface electrocardiogram (ECG) were abrupt and occurred only during the last 1-2 s of the AF episode [5,16].…”

Section: Introductionmentioning

confidence: 99%

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Estimating the time scale and anatomical location of atrial fibrillation spontaneous termination in a biophysical model

Uldry

Jacquemet

Virag

et al. 2012

Med Biol Eng Comput

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Due to their transient nature, spontaneous terminations of atrial fibrillation (AF) are difficult to investigate. Apparently, confounding experimental findings about the time scale of this phenomenon have been reported, with values ranging from 1 s to 1 min. We propose a biophysical modeling approach to study the mechanisms of spontaneous termination in two models of AF with different levels of dynamical complexity. 8 s preceding spontaneous terminations were studied and the evolution of cycle length and wavefront propagation were documented to assess the time scale and anatomical location of the phenomenon. Results suggest that termination mechanisms are dependent on the underlying complexity of AF. During simulated AF of low complexity, the total process of spontaneous termination lasted 3,200 ms and was triggered in the left atrium 800 ms earlier than in the right atrium. The last fibrillatory activity was observed more often in the right atrium. These asymmetric termination mechanisms in both time and space were not observed during spontaneous terminations of complex AF simulations, which showed less predictable termination patterns lasting only 1,600 ms. This study contributes to the interpretation of previous clinical observations, and illustrates how computer modeling provides a complementary approach to study the mechanisms of cardiac arrhythmias.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

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Estimating the time scale and anatomical location of atrial fibrillation spontaneous termination in a biophysical model

Uldry

Jacquemet

Virag

et al. 2012

Med Biol Eng Comput

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“…Clinical studies have been conducted mostly on paroxysmal AF observed from non-invasive 24-h Holter recordings [1,2], from mapping experiments [3] or from data collected in implantable devices [4]. According to these studies, the processes involved in spontaneous AF termination can occur at different time scales.…”

Section: Introductionmentioning

confidence: 99%

“…According to these studies, the processes involved in spontaneous AF termination can occur at different time scales. On the one hand, Alcaraz et al revealed in a study in patients with paroxysmal AF that an atrial organization is detectable in electrocardiographic signals up to one minute prior to termination [2]. On the other hand, a study of 24-h Holter recordings of spontaneous paroxysmal AF terminations by Petrutiu et al showed that the changes in frequency preceding termination are abrupt and occur only during the last 1-2 s of the episode [1].…”

Section: Introductionmentioning

confidence: 99%

Spontaneous termination of atrial fibrillation: Study of the effect of atrial geometry in a biophysical model

Uldry

Virag

Jacquemet

et al. 2009

2009 Annual International Conference of the IEEE Engineering in Medicine and Biology Society

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We studied the mechanisms of spontaneous termination of atrial fibrillation in a biophysical model of human atria, during the eight seconds preceding termination. The earliest detectable changes in the cycle length and the number of wavefronts occurred about three seconds prior to termination. We compared the mechanisms involved in the right and left atrium and investigated the effects of atrial geometry on the termination processes. We observed that cycle length started to increase 800 ms earlier in the left atrium than in the right atrium. Similarly, the number of wavefronts decreased even 1800 ms earlier in the left atrium than in the right one. Significantly fewer episodes terminated in the left atrium. Four areas of the atrial geometry showing distinct termination mechanisms were identified.

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Infra-Hisian Atrioventricular Block Secondary to Radiotherapy

Alcalde-Rodríguez¹,

Rodríguez‐Font²,

Guerra-Ramos³

et al. 2008

Revista Española de Cardiología (English Edition)

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Non-Invasive Characterization of Atrial Activity Immediately Prior to Termination of Paroxysmal Atrial Fibrillation

Cited by 9 publications

References 41 publications

Estimating the time scale and anatomical location of atrial fibrillation spontaneous termination in a biophysical model

Estimating the time scale and anatomical location of atrial fibrillation spontaneous termination in a biophysical model

Spontaneous termination of atrial fibrillation: Study of the effect of atrial geometry in a biophysical model

Infra-Hisian Atrioventricular Block Secondary to Radiotherapy

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