Sepsis and septic shock represent a continuum of illness caused by infection and the subsequent somatic inflammatory response to a pathogen. This continuum of conditions accounts for a significant proportion of admissions and health care dollars spent within the intensive care unit (ICU), with ∼50 million cases of sepsis diagnosed and 11 million deaths due to sepsis in 2017 worldwide. 1 Sepsis, if left unidentified and untreated, will lead to septic shock and ultimately organ dysfunction and death. Despite extensive research over the past 3 decades into the pathophysiology, definition, and treatment of sepsis, recommendations regarding identification and treatment remain ever-changing.