Non-Invasive Continuous Monitoring of Cerebral Blood Flow after Traumatic Brain Injury in Mice Using Fiber Camera-Based Speckle Contrast Optical Spectroscopy

Abstract

We implemented a laser speckle contrast imaging technique with a fiber camera-based approach to monitor blood flow changes in a mouse model post-closed head injury, revealing a significant (~10%, p < 0.05) decrease within 30 minutes. This suggests the potential of blood flow as an early biomarker for head injuries, highlighting the technique's utility for continuous monitoring and clinical translation.