Non-invasive current stimulation in vision recovery: a review of the literature

Perin, C; Viganò, Barbara; Piscitelli, Daniele; Matteo, Barbara Maria; Meroni, Roberto; Cerri, C

doi:10.3233/rnn-190948

Cited by 20 publications

(26 citation statements)

References 56 publications

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“…Non-invasive visual cortex stimulation studies have reported varying fellow eye effects. Studies using inhibitory stimulation protocols (1 Hz rTMS and continuous theta burst stimulation; cTBS) have reported reduced fellow eye contrast sensitivity 35 , 36 whereas those using excitatory protocols (anodal tDCS and tRNS) 24 , 42 , including the present study, observed improvements. This pattern of results is consistent with the homeostasis hypothesis which predicts relatively impaired fellow eye function following inhibitory stimulation and does not rule out improved fellow eye function following excitatory stimulation.…”

Section: Discussioncontrasting

confidence: 56%

“…Transcranial electrical stimulation (tES) refers to a suite of non-invasive neuro-modulation techniques including transcranial direct current stimulation (tDCS), transcranial alternating current stimulation (tACS) and transcranial random noise stimulation (tRNS) that may enhance plasticity in targeted regions of the human brain 21 – 23 , including the visual cortex 24 – 26 . Currently, tES methods are being investigated as a potential neurorehabilitation tool for disorders including stroke 27 – 30 , chronic pain 31 , 32 and tinnitus 33 , 34 and there is growing interest in the use of tES and transorbital stimulation to treat disorders of vision (see 35 – 38 for recent reviews).…”

Section: Introductionmentioning

confidence: 99%

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Repetitive visual cortex transcranial random noise stimulation in adults with amblyopia

Donkor

Silva

Teske

et al. 2021

Sci Rep

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We tested the hypothesis that five daily sessions of visual cortex transcranial random noise stimulation would improve contrast sensitivity, crowded and uncrowded visual acuity in adults with amblyopia. Nineteen adults with amblyopia (44.2 ± 14.9 years, 10 female) were randomly allocated to active or sham tRNS of the visual cortex (active, n = 9; sham, n = 10). Sixteen participants completed the study (n = 8 per group). tRNS was delivered for 25 min across five consecutive days. Monocular contrast sensitivity, uncrowded and crowded visual acuity were measured before, during, 5 min and 30 min post stimulation on each day. Active tRNS significantly improved contrast sensitivity and uncrowded visual acuity for both amblyopic and fellow eyes whereas sham stimulation had no effect. An analysis of the day by day effects revealed large within session improvements on day 1 for the active group that waned across subsequent days. No long-lasting (multi-day) improvements were observed for contrast sensitivity, however a long-lasting improvement in amblyopic eye uncrowded visual acuity was observed for the active group. This improvement remained at 28 day follow up. However, between-group differences in baseline uncrowded visual acuity complicate the interpretation of this effect. No effect of tRNS was observed for amblyopic eye crowded visual acuity. In agreement with previous non-invasive brain stimulation studies using different techniques, tRNS induced short-term contrast sensitivity improvements in adult amblyopic eyes, however, repeated sessions of tRNS did not lead to enhanced or long-lasting effects for the majority of outcome measures.

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Section: Discussioncontrasting

confidence: 56%

Section: Introductionmentioning

confidence: 99%

Repetitive visual cortex transcranial random noise stimulation in adults with amblyopia

Donkor

Silva

Teske

et al. 2021

Sci Rep

View full text Add to dashboard Cite

show abstract

“…Non-invasive visual cortex stimulation studies have reported varying fellow eye effects. Studies using inhibitory stimulation protocols (1 Hz rTMS and continuous theta burst stimulation; cTBS) have reported reduced fellow eye contrast sensitivity [35,36] whereas those using excitatory protocols (anodal tDCS and tRNS) [24,40], including the present study, observed improvements. This pattern of results is consistent with the homeostasis hypothesis which predicts relatively impaired fellow eye function following inhibitory stimulation and does not rule out improved fellow eye function following excitatory stimulation.…”

Section: Trns-induced Improvements In Contrast Sensitivitycontrasting

confidence: 53%

“…Currently, tES methods are being investigated as a potential neurorehabilitation tool for disorders including stroke [27][28][29][30], chronic pain [31,32] and tinnitus [33,34] and there is growing interest in the use of tES to treat disorders of vision (see [35,36] for recent reviews).…”

Section: Introductionmentioning

confidence: 99%

Multi-session visual cortex transcranial random noise stimulation in adults with amblyopia

Donkor

Silva

Teske

et al. 2019

Preprint

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Purpose:We tested the hypothesis that five daily sessions of visual cortex transcranial random noise stimulation would improve contrast sensitivity, crowded and uncrowded visual acuity in adults with amblyopia.Methods: Nineteen adults with amblyopia (44.2 ± 14.9yrs, 10 female) were randomly allocated to active or sham tRNS of the visual cortex (active, n = 9; sham, n = 10). tRNS was delivered for 25 minutes across five consecutive days. Monocular contrast sensitivity, uncrowded and crowded visual acuity were measured before, during, 5 minutes and 30 minutes post stimulation on each day. Results:Active tRNS significantly improved contrast sensitivity for both amblyopic and fellow eyes whereas sham stimulation had no effect. An analysis of the day by day effects revealed large within session improvements on day 1 for the active group that waned across subsequent days. No long-lasting changes in baseline contrast sensitivity were observed in the active group.The uncrowded visual acuity measurements followed the same trend, but differences in baseline uncrowded visual acuity between the two groups prevent definitive conclusions. No effect of tRNS was observed for crowded visual acuity. Conclusions:In agreement with previous non-invasive brain stimulation studies using different techniques, tRNS induced short-term contrast sensitivity improvements in adult amblyopic eyes, and the effects may extend to uncrowded visual acuity. However, multiple sessions of tRNS did not lead to enhanced or long-lasting effects. Multi-modal approaches to adult amblyopia treatment that combine non-invasive brain stimulation with other interventions may be required to induce long lasting improvements in visual function.

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“…Regarding the effects of each tDCS method, it is suggested that bihemispheric tDCS has a more significant effect on chronic stroke [ 6 – 8 ]. Moreover, the positive effect of each tDCS approach on stroke motor recovery has been elucidated by previous studies [ 9 – 13 ]. Notably, recent systematic reviews reported the improvement of upper limb (UL) sensorimotor functions and improvement of activities of daily living following tDCS in post-stroke individuals [ 8 – 10 , 14 ].…”

Section: Introductionmentioning

confidence: 94%

Baseline Motor Impairment Predicts Transcranial Direct Current Stimulation Combined with Physical Therapy-Induced Improvement in Individuals with Chronic Stroke

et al. 2020

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Transcranial direct current stimulation (tDCS) can enhance the effect of conventional therapies in post-stroke neurorehabilitation. The ability to predict an individual’s potential for tDCS-induced recovery may permit rehabilitation providers to make rational decisions about who will be a good candidate for tDCS therapy. We investigated the clinical and biological characteristics which might predict tDCS plus physical therapy effects on upper limb motor recovery in chronic stroke patients. A cohort of 80 chronic stroke individuals underwent ten to fifteen sessions of tDCS plus physical therapy. The sensorimotor function of the upper limb was assessed by means of the upper extremity section of the Fugl-Meyer scale (UE-FM), before and after treatment. A backward stepwise regression was used to assess the effect of age, sex, time since stroke, brain lesion side, and basal level of motor function on UE-FM improvement after treatment. Following the intervention, UE-FM significantly improved ( p < 0.05 ), and the magnitude of the change was clinically important (mean 6.2 points, 95% CI: 5.2–7.4). The baseline level of UE-FM was the only significant predictor ( R 2 = 0.90 , F 1 , 76 = 682.80 , p < 0.001 ) of tDCS response. These findings may help to guide clinical decisions according to the profile of each patient. Future studies should investigate whether stroke severity affects the effectiveness of tDCS combined with physical therapy.

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Non-invasive current stimulation in vision recovery: a review of the literature

Cited by 20 publications

References 56 publications

Repetitive visual cortex transcranial random noise stimulation in adults with amblyopia

Repetitive visual cortex transcranial random noise stimulation in adults with amblyopia

Multi-session visual cortex transcranial random noise stimulation in adults with amblyopia

Baseline Motor Impairment Predicts Transcranial Direct Current Stimulation Combined with Physical Therapy-Induced Improvement in Individuals with Chronic Stroke

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