Non-invasive deep tissue imaging of iodine modified poly(caprolactone-co-1-4-oxepan-1,5-dione) using X-ray

Olsen, Timothy R.; Davis, Lundy L.; Nicolau, Samantha E.; Duncan, Caroline C.; Whitehead, Daniel C.; Horn, Brooke A. Van; Alexis, Frank

doi:10.1016/j.actbio.2015.03.021

Cited by 23 publications

(17 citation statements)

References 27 publications

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“…Additionally, this novel polymer system was developed to exploit the biodegradable and biocompatible characteristics of poly(ε‐caprolactone), both increasingly important priorities for polymer systems to be used in vivo . Current and future studies are planned to address the ability to image the polymer in soft tissues, to examine materials degradation kinetics and by‐products, and determine the biocompatibility to more fully understand the biological applications of this promising material.…”

Section: Discussionmentioning

confidence: 99%

Oxime functionalization strategy for iodinated poly(epsilon-caprolactone) X-ray opaque materials

Nicolau

Davis

Duncan

et al. 2015

J. Polym. Sci. Part A: Polym. Chem.

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Since two of the most common technologies for imaging the human body are X‐ray radiography and computed tomography (CT), researchers are focused on developing biodegradable and biocompatible polymeric molecules as an alternative to the traditional small molecule contrast agents. This report highlights the synthesis of novel biodegradable iodinated poly(ε‐caprolactone) copolymers by oxime “Click” ligation reactions. A series of ketone‐bearing materials are built by tin (II)‐mediated ring‐opening polymerization followed by a postpolymerization deprotection step. The intended X‐ray opacity is imparted through acid‐catalyzed oxime postpolymerization modification of the resultant polymers with an iodinated hydroxylamine. All small molecules and polymeric materials are characterized using proton nuclear magnetic resonance (NMR) for purity, functional group stoichiometry, and number‐averaged molecular weight calculations. Additionally, the polymers are evaluated with gel permeation chromatography (GPC) to determine polymer sample polydispersity and general molecular weight distribution shapes and by differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA) for thermal properties. © 2015 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2015, 53, 2421–2430

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Section: Discussionmentioning

confidence: 99%

Oxime functionalization strategy for iodinated poly(epsilon-caprolactone) X-ray opaque materials

Nicolau

Davis

Duncan

et al. 2015

J. Polym. Sci. Part A: Polym. Chem.

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“…A vast number of publications have investigated the use of polyester contrast agents for the enhancement of X‐ray scanning in both in vitro and in vivo . In 2015, a novel radiopaque 3D printable bone screw based on a poly‐ l ‐lactide composite, which contained 20% IONPs (Fe 3 O 4 ), was reported.…”

Section: Polyesters With Imaging Contrast Propertiesmentioning

confidence: 99%

“…Next, the biocompatibility and CT contrast properties for deep tissue imaging were studied . Deep tissue imaging is critical for possible clinical translation.…”

Section: Polyesters With Imaging Contrast Propertiesmentioning

confidence: 99%

Section: Polyesters With Imaging Contrast Propertiesmentioning

confidence: 99%

Section: Polyesters With Imaging Contrast Propertiesmentioning

confidence: 99%

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Recent Advances in Polyesters for Biomedical Imaging

Attia

Brummel

Lex

et al. 2018

Adv Healthcare Materials

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Several synthetic materials exhibiting contrast imaging properties have become vital to the field of biomedical imaging. Polymeric biomaterials and metals are commonly used imaging agents and can assist in the monitoring of therapy response, migration, degradation, changes in morphology, defects, and image-guided surgery. In comparison to metals, most bio and synthetic polymers lack inherent imaging properties. Polymeric biomaterials, specifically polyesters, have gained a considerable amount of attention due to their unique properties including biocompatibility, biodegradation, facile synthesis, and modification capability. Polyester implants and nanomaterials are available on the market or are in clinical trials for many applications including: dental implants, cranio-maxilofacial implants, soft tissue sutures and staples, abdominal wall repair, tendon and ligament reconstruction, fracture fixation devices, and coronary drug eluting stents. This review aims to provide a summary of the recent developments of polyesters with bioimaging contrast properties. The three main approaches to prepare bioimaging polyesters (coating, encapsulation, and functionalization) are discussed in depth. Furthermore, commonly used imaging modalities including X-ray computed tomography, magnetic resonance imaging, ultrasound, fluorescence, and radionucleotide polyester contrast agents are highlighted. In each section, examples of impactful bioimaging polyesters in the five major imaging modalities are evaluated.

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Development of 3D Printed Biodegradable, Entirely X‐ray Visible Stents for Rabbit Carotid Artery Implantation

Shen,

Tang,

Sun

et al. 2024

Adv Healthcare Materials

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Biodegradable stents have been considered a promising strategy for the endovascular treatment (EVT) of cerebrovascular diseases. The visualization of biodegradable stents is of significance during the implantation and long‐term follow‐up. Endowing the biodegradable stents with X‐ray radiopacity can overcome the weakness of intrinsic radioparency of polymers. Hence, this work focused on the development of an entirely X‐ray visible biodegradable stent (PCL‐KIO3) composed of polycaprolactone (PCL) and potassium iodate via physical blending and 3D printing for cerebrovascular application. The PCL‐KIO3 stents were implanted into the rabbit carotid artery to evaluate the imaging performance in vivo and biosafety. The in vitro X‐ray imaging results showed that the introduction of potassium iodate made the 3D printed PCL stents visualizable under X‐ray. So far, there is inadequate study about polymeric stent visualization in vivo. Therefore, the entirely X‐ray visible stents were implanted into the rabbit carotid artery to evaluate the biosafety and visibility performance. In the process of stent deployment, the visualization of PCL‐KIO3 stent effectively help us understand the position and dilation status of stents. At 6‐month follow‐up, the PCL‐KIO3 stent could still be observed under X‐ray and maintained excellent vessel patency. To sum up, this study demonstrated that PCL‐KIO3 stent may provide a robust strategy for biodegradable stent visualization.This article is protected by copyright. All rights reserved

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Non-invasive deep tissue imaging of iodine modified poly(caprolactone-co-1-4-oxepan-1,5-dione) using X-ray

Cited by 23 publications

References 27 publications

Oxime functionalization strategy for iodinated poly(epsilon-caprolactone) X-ray opaque materials

Oxime functionalization strategy for iodinated poly(epsilon-caprolactone) X-ray opaque materials

Recent Advances in Polyesters for Biomedical Imaging

Development of 3D Printed Biodegradable, Entirely X‐ray Visible Stents for Rabbit Carotid Artery Implantation

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