Non-invasive detection of total bilirubin based on multi-wavelength PPG signal

Cheng, Leiyang; Nawaz, Muhammad Zeehan; Fan, Meiling; Li, Gang

doi:10.1016/j.cmpb.2023.107570

Cited by 3 publications

(2 citation statements)

References 26 publications

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“…Bilirubin, for example, is a well‐established marker of liver function and, at high levels, potentially harmful to the brain and nervous system. [ 42 , 43 ] With further advances in miniature spectrometric sensors, it becomes possible to create new PPG‐based techniques: Inverting the sensor configuration from narrow‐band LEDs and a wide‐band photodiode to a wide‐band LED and a spectometric detector would maximize the available information content and thus increase the accuracy of current PPG parameters by optimizing, perhaps dynamically, the wavelength and create a wealth of new parameters that could combine shorter‐wavelength (microcirculation‐related) parameters with longer‐wavelength (macrocirculation‐related) parameters. An example of the latter is the arteriolar PTT, calculated using PPG signals recorded at blue, yellow, and infrared wavelengths, recently used in ref.…”

Section: Discussionmentioning

confidence: 99%

Non‐Invasive Hemodynamic Monitoring System Integrating Spectrometry, Photoplethysmography, and Arterial Pressure Measurement Capabilities

Sirkiä,

Panula,

Kaisti

2024

Advanced Science

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Minimally invasive and non‐invasive hemodynamic monitoring technologies have recently gained more attention, driven by technological advances and the inherent risk of complications in invasive techniques. In this article, an experimental non‐invasive system is presented that effectively combines the capabilities of spectrometry, photoplethysmography (PPG), and arterial pressure measurement. Both time‐ and wavelength‐resolved optical signals from the fingertip are measured under external pressure, which gradually increased above the level of systolic blood pressure. The optical channels measured at 434–731 nm divided into three groups separated by a group of channels with wavelengths approximately between 590 and 630 nm. This group of channels, labeled transition band, is characterized by abrupt changes resulting from a decrease in the absorption coefficient of whole blood. External pressure levels of maximum pulsation showed that shorter wavelengths (<590 nm) probe superficial low‐pressure blood vessels, whereas longer wavelengths (>630 nm) probe high‐pressure arteries. The results on perfusion indices and DC component level changes showed clear differences between the optical channels, further highlighting the importance of wavelength selection in optical hemodynamic monitoring systems. Altogether, the results demonstrated that the integrated system presented has the potential to extract new hemodynamic information simultaneously from macrocirculation to microcirculation.

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Section: Discussionmentioning

confidence: 99%

Non‐Invasive Hemodynamic Monitoring System Integrating Spectrometry, Photoplethysmography, and Arterial Pressure Measurement Capabilities

Sirkiä,

Panula,

Kaisti

2024

Advanced Science

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“…The efficacy of noninvasive blood collection techniques has been validated in multiple studies and is comparable to the results obtained from invasive tests. [ 67 , 68 ] The incorporation of pneumatic logistics with advanced robotics represents a novel technological advancement in the transportation of medical drugs and samples. The integration of pneumatic logistics with intelligent robotics offers higher efficiency and greater sample stability compared to traditional transportation modes, thereby enhancing operational efficiency.…”

Section: Discussionmentioning

confidence: 99%

Research progress on humoral biomarkers of Alzheimer’s disease: A review

Zhang,

Fu,

Yang

et al. 2024

Medicine

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Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by progressive memory loss. The main pathological features are neuronal fibrillary tangles caused by amyloid beta deposition and hyperphosphorylation of tau protein, accompanied by neuronal death and loss of synaptic structure. Early diagnosis is the key to the treatment of AD. It is known that some small molecular components are related to the pathogenesis of AD. This article will summarize the common AD biomarkers in cerebrospinal fluid and blood and analyze the current status of AD biomarkers and future research directions. This review summarizes the promising biomarkers for the diagnosis of AD in the last decade and describes their changes in AD body fluids. The diagnostic biomarkers related to AD were mainly distributed in cerebrospinal fluid and blood. Significant changes in these molecules can be detected in cerebrospinal fluid and blood, and they are correlated with AD severity. These humoral molecules have necessary relationship with AD and can be used as AD biomarkers to assist early diagnosis of AD.

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