Non-invasive diagnosis of liver fibrosis: A review of current imaging modalities

Wu, Ling; Shen, Yue; Li, Feng

doi:10.1016/j.gastre.2019.11.006

Cited by 2 publications

(3 citation statements)

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“…Liver biopsy remains the gold standard for both diagnosis and staging of fibrosis, but it is largely suboptimal due to its invasive nature and various associated complications. To overcome this, several non-invasive diagnostic methods based on serum biomarkers and imaging techniques have been developed [13]. Serum biomarkers exclude a lot of the concerns related to liver biopsy.…”

Section: Vmentioning

confidence: 99%

Novel Prognostic Indicators to reflect the grade of liver fibrosis in hepatic patients

El-Gazar¹,

Fahmi

Mohamed³

et al. 2021

Egypt. J. Chem.

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Background: Liver fibrosis is the result of a sustained wound healing response to chronic liver injury. The main reasons include chronic hepatitis C virus (HCV), hepatitis B virus (HBV) infection, and Non-alcoholic fatty liver disease (NAFLD). Non-invasive methods of assessing fibrosis are often used in clinical practice as a safer, more accessible, and less costly way than liver biopsy to stratify individuals by risk. The current study early diagnosis of liver fibrosis in patients with hepatitis B, C, and NAFLD using indirect non-invasive biomarkers and evaluating the diagnostic impact of the Study applied on 250 patients divided into five equal groups: HBV Group, HCV Group, HBV + HCV Group, NAFLD Group and Control Group, for each with the same inclusion and exclusion criteria in order to monitor the prevalence of Apolipoprotein B (ApoB) (g/L), Lipoprotein A (mg/dL), Serum Amyloid A (SAA) (mg/L) and Insulin-like growth factor 1 (IGF1) (ng/ml) as biomarkers reflecting the grade of liver fibrosis in hepatic patients. Results: In the terms of Alanine aminotransferase ALT (p<0.05), Gamma-glutamyltransferase GGT (p<0.001), Glycosylated hemoglobin HbA1C (p<0.001), and Apo B(p<0.001), in the NAFLD group, had the highest value. Meanwhile, the terms of Aspartate aminotransferase AST (p<0.001), Aspartate aminotransferase to platelet ratio index APRI (p<0.001), total bilirubin (p<0.05), and Serum Amyloid A SAA (p<0.001)in the HCV group had the greatest value. In ddition, the HBV+HCV group had the highest AST/ALT value (p<0.001), 2 macroglobulin(p<0.001) values. platelets (p<0.001), haptoglobin (p<0.001), lipoprotein A (p<0.001), and Insulin-like growth factor 1 IGF1(p<0.001) were all greatest in the control group. The biomarkers Lipoprotein (A) in HBV and NAFLD; Apolipoprotein B (ApoB) in HCV and HBV+ HCV group were found to be predictive of early fibrosis using Receiver Operator Characteristics (ROC) curves. Conclusion:The estimation of non-invasive biomarkers (ApoB), (IGF1), (SAA), and Lipoprotein A were the most predictive of early fibrosis in hepatic patients with significant accuracy. These biomarkers can be used as liver biopsy alternatives to support the early diagnosis of liver fibrosis

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Section: Vmentioning

confidence: 99%

Novel Prognostic Indicators to reflect the grade of liver fibrosis in hepatic patients

El-Gazar¹,

Fahmi

Mohamed³

et al. 2021

Egypt. J. Chem.

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“…Regarding magnetic resonance (MR) imaging (MRI), several ongoing researches have put forth many noninvasive techniques for the diagnosis of liver fibrosis, including MR elastography (MRE), hepatobiliary contrast-enhanced MRI, multi-b-value diffusion-weighted imaging (DWI) with different models, and quantitative T1, T2, T1ρ, and T2* mapping. 1,2 Inflammation and fibrosis are strongly associated in the course of chronic liver disease, and can occur at any stage of liver fibrosis. Most of the early studies have focused on exploring new MR techniques for staging liver fibrosis.…”

mentioning

confidence: 99%

“…Finding a simple, noninvasive, and accurate method for diagnosing and staging liver fibrosis has become a hotspot of clinical research. Regarding magnetic resonance (MR) imaging (MRI), several ongoing researches have put forth many noninvasive techniques for the diagnosis of liver fibrosis, including MR elastography (MRE), hepatobiliary contrast‐enhanced MRI, multi‐b‐value diffusion‐weighted imaging (DWI) with different models, and quantitative T1, T2, T1ρ, and T2* mapping 1,2 …”

mentioning

confidence: 99%

Editorial for “Characterizing Fibrosis and Inflammation in a Partial Bile Duct Ligation Mouse Model by Multiparametric Magnetic Resonance Imaging”

Qiu

Xie

Shen

2021

Magnetic Resonance Imaging

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Non-invasive diagnosis of liver fibrosis: A review of current imaging modalities

Cited by 2 publications

References 58 publications

Novel Prognostic Indicators to reflect the grade of liver fibrosis in hepatic patients

Novel Prognostic Indicators to reflect the grade of liver fibrosis in hepatic patients

Editorial for “Characterizing Fibrosis and Inflammation in a Partial Bile Duct Ligation Mouse Model by Multiparametric Magnetic Resonance Imaging”

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