Non-invasive endothelial function assessment using digital reactive hyperaemia correlates with three-dimensional intravascular ultrasound and virtual histology-derived plaque volume and plaque phenotype

Kovárník, Tomáš; Jerabek, Stepan; Chen, Zhi; Wahle, Andreas; Zhang, Ling; Dostálová, Gabriela; Skalická, Hana; Král, Aleš; Horák, Jan; Sonka, Milan; Linhart, Aleš

doi:10.5603/kp.a2016.0062

Cited by 3 publications

(3 citation statements)

References 24 publications

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“…Vasomotor tone and appropriate blood pressure are maintained by the vascular endothelium, which responds to shear stress generated by increased blood flow and stimulates vasodilation [1]. Vascular damage is caused and intensified by endothelial dysfunction, which induces chronic inflammation of the vasculature, followed by the development of atherosclerosis and cardiovascular disease [2][3][4][5][6]. The endothelium is composed of a monolayer of endothelial cells that function as an endocrine organ and a 0.2-2-μm-thick, negatively charged surface layer called the glycocalyx, which is a primary-functional barrier for endothelial cell protection [7,8].…”

Section: Introductionmentioning

confidence: 99%

“…The method to monitor the response of a conduit artery endothelium is flowmediated dilation (FMD) [9], and reactive hyperemia-peripheral arterial tonometry (RH-PAT) has been developed to assess endothelial function in the small arteries of the fingers [10]. These methods are thought to significantly predict the risks of cardiovascular and cerebrovascular events, including angina, myocardial infarction, ischemic stroke, cerebral infarction, acute coronary syndrome, and heart failure [2][3][4][5]. Recently, RH-PAT and FMD have been compared, and it was suggested that these two methodologies are not associated and reflect different aspects of cardiovascular risks.…”

Section: Introductionmentioning

confidence: 99%

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Peripheral endothelial function can be improved by daily consumption of water containing over 7 ppm of dissolved hydrogen: A randomized controlled trial

Ishibashi¹,

Kawamoto²,

Matsuno³

et al. 2020

PLoS ONE

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BackgroundMeasurement of the reactive hyperemia index (RHI) using peripheral arterial tonometry (PAT) has shown benefits in the evaluation of vascular endothelial function and prediction of cardiovascular disease prognosis. Thus, it is important to examine the factors that promote the RHI. In this study, we aimed to investigate the effect of molecular hydrogen (H 2 ) on reactive hyperemia-PAT of the small arteries of fingers in healthy people. MethodsTo determine the efficacy of H 2 for improving peripheral vascular endothelial function, water containing high H 2 concentrations was administered to participants, and the Ln_RHI was measured in the finger vasculature. Sixty-eight volunteers were randomly divided into two groups: a placebo group (n = 34) that drank molecular nitrogen (N 2 )-containing water and a high H 2 group (n = 34) that drank high H 2 water (containing 7 ppm of H 2 : 3.5 mg H 2 in 500-mL water). The Ln_RHI was measured before ingesting the placebo or high H 2 water, 1 h and 24 h after the first ingestion, and 14 days after daily ingestion of high H 2 water or the placebo. The mixed effects model for repeated measures was used in data analysis. ResultsThe high H 2 group had a significantly greater improvement in Ln_RHI than the placebo group. Ln_RHI improved by 22.2% (p<0.05) at 24 h after the first ingestion of high H 2 water and by 25.4% (p<0.05) after the daily consumption of high H 2 water for 2 weeks.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Peripheral endothelial function can be improved by daily consumption of water containing over 7 ppm of dissolved hydrogen: A randomized controlled trial

Ishibashi¹,

Kawamoto²,

Matsuno³

et al. 2020

PLoS ONE

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“…Although the relationships between RHI and pathologic levels of coronary atherosclerosis have been studied, there are no reports of vascular endothelial function tests in cases of other inflammatory skin diseases or wound healing other than keloids. In addition, we did not study the relationship between the pathology of keloids, RHI, and the pathology of blood vessels; therefore, it is difficult to define the pathological levels of keloids and RHI.…”

Section: Discussionmentioning

confidence: 99%

Endothelial dysfunction may promote keloid growth

Noishiki

Takagi

Kubota

et al. 2017

Wound Repair Regeneration

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Keloid is a cutaneous fibroproliferative disorder. It results from impaired wound healing that generates persistent inflammation and extensive deposition of collagen fibers in the wound/scar. Keloids tend to be worse in hypertensive patients. The present prospective cross-sectional study assessed whether endothelial dysfunction, which occurs in hypertension, associates with keloid formation and progression. This study included randomly selected patients with keloids who were assessed for surgical keloid treatment in 2013-2014. A series of nonkeloid patients admitted to the hospital was also recruited during this period. To measure endothelial function, all patients underwent digital reactive hyperemia peripheral arterial tonometry. Test results were expressed as reactive hyperemia index (RHI) and augmentation index (AI). In total, 57 patients with keloids and 19 nonkeloid controls were recruited. Keloid patients did not differ from the controls in terms of demographic or clinical variables, but had significantly worse RHI and AI values. Moreover, poor RHI and AI values associated with keloid development on binomial logistic regression. The keloid patients were then divided into four groups depending on whether their keloids started at age 0-12, 13-18, 19-29, or ≥30 years. Patients whose keloids arose before and well after puberty tended to have lower RHI than the controls, but these differences did not achieve statistical significance. However, these two groups did have significantly poorer AI values than the controls. Thus, endothelial dysfunction could cause keloid formation and/or aggravation. This indicates that vascular endothelial cells are important for wound healing.

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Assessments of Perfusion, Blood Flow, and Vascular Structure in Ambulatory Subjects: Guidance for Translational Research Scientists

et al. 2023

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Research involving human subjects in ambulatory settings is a critical link in the chain comprising translational research, spanning preclinical research to human subject and patient cohort studies. There are presently a wide array of techniques and approaches available to investigators wishing to study blood flow, perfusion, and vascular structure and function in human subjects. In this multi-sectioned review, we discuss capillaroscopy, carotid intima-media thickness, flow-mediated dilation, laser Doppler flowmetry, near-infrared spectroscopy, peripheral arterial tonometry, pulse wave velocity, retinal fundus imaging, and vascular plethysmography. Each section contains a general overview and the physical basis of the technique followed by a discussion of the procedures involved and the necessary equipment, with attention paid to specific requirements or limitations. Subsequently, we detail which aspects of vascular function can be studied with a given technique, the analytical approach to the collected data, and the appropriate application and limitation(s) to the interpretation of the data collected. Finally, a modified scoping review provides a summary of how each assessment technique has been applied in previous studies. It is anticipated that this review will provide an efficient source of information and insight for preclinical investigators seeking to add translational aspects to their research programs.

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Non-invasive endothelial function assessment using digital reactive hyperaemia correlates with three-dimensional intravascular ultrasound and virtual histology-derived plaque volume and plaque phenotype

Cited by 3 publications

References 24 publications

Peripheral endothelial function can be improved by daily consumption of water containing over 7 ppm of dissolved hydrogen: A randomized controlled trial

Peripheral endothelial function can be improved by daily consumption of water containing over 7 ppm of dissolved hydrogen: A randomized controlled trial

Endothelial dysfunction may promote keloid growth

Assessments of Perfusion, Blood Flow, and Vascular Structure in Ambulatory Subjects: Guidance for Translational Research Scientists

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