Non-invasive estimation of static and pulsatile intracranial pressure from transcranial acoustic signals

Levinsky, Alexandra; Papyan, Surik; Weinberg, Guy; Stadheim, Trond; Eide, Per Kristian

doi:10.1016/j.medengphy.2016.02.009

Cited by 24 publications

(14 citation statements)

References 19 publications

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“…Despite a wide range of approaches over long time, clinically viable non-invasive ICP monitoring is still not a reality. There are techniques that provide promising results 49 – 51 , but these are currently lacking clinical validation. The importance of ICP level in the case of traumatic brain injury and critical pathologies is well documented, but due to the lack of a good non-invasive monitoring technique, the role played by ICP is unknown in several different less critical pathologies.…”

Section: Discussionmentioning

confidence: 99%

Utility of the Tympanic Membrane Pressure Waveform for Non-invasive Estimation of The Intracranial Pressure Waveform

Evensen

Paulat

Prieur

et al. 2018

Sci Rep

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Time domain analysis of the intracranial pressure (ICP) waveform provides important information about the intracranial pressure-volume reserve capacity. The aim here was to explore whether the tympanic membrane pressure (TMP) waveform can be used to non-invasively estimate the ICP waveform. Simultaneous invasive ICP and non-invasive TMP signals were measured in a total of 28 individuals who underwent invasive ICP measurements as a part of their clinical work up (surveillance after subarachnoid hemorrhage in 9 individuals and diagnostic for CSF circulation disorders in 19 individuals). For each individual, a transfer function estimate between the invasive ICP and non-invasive TMP signals was established in order to explore the potential of the method. To validate the results, ICP waveform parameters including the mean wave amplitude (MWA) were computed in the time domain for both the ICP estimates and the invasively measured ICP. The patient-specific non-invasive ICP signals predicted MWA rather satisfactorily in 4/28 individuals (14%). In these four patients the differences between original and estimated MWA were <1.0 mmHg in more than 50% of observations, and <0.5 mmHg in more than 20% of observations. The study further disclosed that the cochlear aqueduct worked as a physical lowpass filter.

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Section: Discussionmentioning

confidence: 99%

Utility of the Tympanic Membrane Pressure Waveform for Non-invasive Estimation of The Intracranial Pressure Waveform

Evensen

Paulat

Prieur

et al. 2018

Sci Rep

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“…Previous studies have explored various types of continuous non-invasive source signals to estimate ICP. [4][5][6][7] Continuous monitoring of the optic nerve with OCT is, to our knowledge, not available. Yet, a single time point examination may be used to estimate the presence of normal or abnormal ICP.…”

Section: Discussionmentioning

confidence: 99%

Non-invasive Estimation of Pulsatile and Static Intracranial Pressure by Optical Coherence Tomography

Jacobsen

Jørstad

Moe

et al. 2021

Preprint

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This study examined whether optical coherence tomography (OCT) can be used to estimate the pulsatile and static intracranial pressure (ICP) in patients with idiopathic intracranial hypertension (IIH). Continuous overnight monitoring of the pulsatile and static ICP and a single OCT examination were performed in 20 patients with IIH and in 12 reference subjects without cerebrospinal fluid disturbances. The ICP measurements were obtained using a parenchymal sensor. The pulsatile ICP was determined as the mean ICP wave amplitude (MWA) and the static ICP was determined as the mean ICP. The IIH group had increased overnight MWA and mean ICP scores, and OCT demonstrated anterior deflection of the peripapillary Bruch’s membrane angle (pBA) and increased optic nerve head height (ONHH). There was a significant positive correlation between the pBA and ONHH and the overnight MWA scores, and between mean ICP and ONHH. The pBA and the ONHH also predicted abnormal overnight MWA, but the predictive power of mean ICP was non-significant after adjusting for age and body mass index. This study suggest that the OCT parameters pBA and ONHH can predict abnormal MWA scores.

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“…The transmission of ultrasound through the human cranial bone is very important for non-invasive transcranial acoustic imaging (Errico et al, 2016;Jordan et al, 2017), therapeutic applications such as the ablation of brain tumors (Pernot et al, 2007;Colen and Jolesz, 2010;Mcdannold et al, 2010;Damianou, 2019), and mechanical brain thrombosis ablation angioplasty (Behrens et al, 2001;Liu et al, 2014;Lee et al, 2016;Levinsky et al, 2016). Recently, transcranial ultrasound becomes an alternative approach for neuromodulation techniques, as ultrasound can non-invasively transmit to deep targeted brain circuits (Darrow, 2019;Li et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Numerical Evaluation of the Influence of Skull Heterogeneity on Transcranial Ultrasonic Focusing

Jiang

et al. 2020

Front. Neurosci.

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In transcranial penetration, ultrasound undergoes refraction, diffraction, multi-reflection, and mode conversion. These factors lead to phase aberration and waveform distortion, which impede the realization of transcranial ultrasonic imaging and therapy. Ray tracing has been used to correct the phase aberration and is computationally more efficient than traditional full-wave simulation. However, when ray tracing has been used for transcranial investigation, it has generally been on the premise that the skull medium is homogeneous. To find suitable homogeneity that balances computational speed and accuracy, the present work investigates how the focus deviates after phaseaberration compensation with ray tracing using time-reversal theory. The waveforms are synthetized with ray tracing for phase aberration, by which the properties of the skull bone are simplified for refraction calculation as those of either (i) the cortical bone or (ii) the mean of the entire skull bone, and the focusing accuracy is evaluated for each hypothesis. The propagation of ultrasound for transcranial focusing is simulated with the elastic model using the k-space pseudospectral method. Unlike the fluid model, the elastic model does not omit shear waves in the skull bones, and the influence of that omission is investigated, with the fluid model resulting in a focal deflection of 0.5 mm. The focusing deviations are huge when the properties of the skull bone are idealized with ray tracing as those of the mean of the entire skull bone. The focusing accuracy improves when the properties of the skull bone are idealized as those of the cortical bone. The results reveal minimal deviation (8.6, 3.9, and 3.2% in the three Cartesian coordinates) in the focal region and suggest that transcranial focusing deflections are caused mostly by ultrasonic refraction on the surface of the skull bone. A heterogeneous skull bone causes wave bending but minimal focusing deflection. The proposed simplification of a homogeneous skull bone is more accurate for transcranial ultrasonic path estimation and offers promising applications in transcranial ultrasonic focusing and imaging.

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Non-invasive estimation of static and pulsatile intracranial pressure from transcranial acoustic signals

Cited by 24 publications

References 19 publications

Utility of the Tympanic Membrane Pressure Waveform for Non-invasive Estimation of The Intracranial Pressure Waveform

Utility of the Tympanic Membrane Pressure Waveform for Non-invasive Estimation of The Intracranial Pressure Waveform

Non-invasive Estimation of Pulsatile and Static Intracranial Pressure by Optical Coherence Tomography

Numerical Evaluation of the Influence of Skull Heterogeneity on Transcranial Ultrasonic Focusing

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