2017
DOI: 10.1016/j.pathol.2017.08.010
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Non-invasive fetal RHD genotyping for RhD negative women stratified into RHD gene deletion or variant groups: comparative accuracy using two blood collection tube types

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Cited by 19 publications
(19 citation statements)
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“…No studies of the diagnostic-therapeutic chain were identified. 70 studies on diagnostic accuracy including approximately 66,000 participants were identified (all in bibliographic databases), of which the 12 largest (including over 90% of the total study population) were included in the analysis [5,[17][18][19][20][21][22][23][24][25][26][27][28]. Two controlled intervention studies investigating the benefit (prevention of sensitization) of antenatal anti-D prophylaxis were identified (in bibliographic databases).…”
Section: Resultsmentioning
confidence: 99%
“…No studies of the diagnostic-therapeutic chain were identified. 70 studies on diagnostic accuracy including approximately 66,000 participants were identified (all in bibliographic databases), of which the 12 largest (including over 90% of the total study population) were included in the analysis [5,[17][18][19][20][21][22][23][24][25][26][27][28]. Two controlled intervention studies investigating the benefit (prevention of sensitization) of antenatal anti-D prophylaxis were identified (in bibliographic databases).…”
Section: Resultsmentioning
confidence: 99%
“…Non‐invasive prenatal testing (NIPT) of cell‐free fetal (cff) DNA in maternal plasma determines whether the target paternal blood group allele has been inherited, thus predicting whether the fetus is at risk for HDFN. NIPT has proven reliable for fetal RHD genotyping for D‐negative pregnant women (Finning et al , ; Mackie et al , ; Hyland et al , ). Conventional real‐time PCR allows ready detection of fetal RHD sequences because the RHD gene is deleted on the D‐negative haplotype in the majority of cases (Colin et al , ).…”
Section: Primer and Probe Sequences For Droplet Digital Pcr Assaysmentioning
confidence: 99%
“…However, although the current study estimated that more than 2 million doses of IgG anti-Rh(D) should be administered annually in High Income countries to provide both antenatal and post-partum immunoprophylaxis, we found that only~1.7 million doses were actually administered annually. Nonetheless, it is possible that this difference is somewhat overestimated, because some High Income countries use non-invasive fetal Rh(D) genotyping programs to limit antenatal immunoprophylaxis to cases where the fetus is genotyped as Rh(D)-positive [24].…”
Section: Discussionmentioning
confidence: 99%