Non-invasive glucose monitoring in patients with diabetes: A novel system based on impedance spectroscopy

Caduff, Andreas; Dewarrat, F.; Talary, Mark S.; Stalder, G; Heinemann, Lutz; Feldman, Yuri

doi:10.1016/j.bios.2006.01.031

Cited by 131 publications

(86 citation statements)

References 30 publications

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“…The continuous progress of medical applications of electrical bioimpedance spectroscopy (EBIS) (Aberg et al 2005, Moissl et al 2006, Caduff et al 2006, combined with recent advances in textile electrode technology (Pacelli et al 2006, Paradiso andDe Rossi 2006), enable the development of bioimpedance-based measurement systems for home monitoring (Medrano et al 2007 and personal monitoring (Scheffler et al 2003).…”

Section: Introductionmentioning

confidence: 99%

An analog front-end enables electrical impedance spectroscopy system on-chip for biomedical applications

et al. 2008

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The increasing number of applications of electrical bioimpedance measurements in biomedical practice, together with continuous advances in textile technology, has encouraged several researchers to make the first attempts to develop portable, even wearable, electrical bioimpedance measurement systems. The main target of these systems is personal and home monitoring. Analog Devices has made available AD5933, a new system-onchip fully integrated electrical impedance spectrometer, which might allow the implementation of minimum-size instrumentation for electrical bioimpedance measurements. However, AD5933 as such is not suitable for most applications of electrical bioimpedance. In this work, we present a relatively simple analog front-end that adapts AD5933 to a four-electrode strategy, allowing its use in biomedical applications for the first time. The resulting impedance measurements exhibit a very good performance in aspects like load dynamic range and accuracy. This type of minimum-size, system-on-chip-based bioimpedance measurement system would lead researchers to develop and implement light and wearable electrical bioimpedance systems for home and personal health monitoring applications, a new and huge niche for medical technology development.

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Section: Introductionmentioning

confidence: 99%

An analog front-end enables electrical impedance spectroscopy system on-chip for biomedical applications

et al. 2008

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“…56 This forms the principle of glucose detection using impedance spectroscopy, which utilizes the transport of alternating current through the tissue to measure changes in plasma conductivity and subsequently relates this to glucose concentrations. [57][58][59][60][61] 2. Electromagnetic spectroscopy utilizes changes in the electromagnetic coupling between two inductors to measure glucose concentration.…”

Section: Other Approachesmentioning

confidence: 99%

Technologies for Continuous Glucose Monitoring: Current Problems and Future Promises

Vaddiraju

Burgess

Tomazos

et al. 2010

J Diabetes Sci Technol

230

224

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Devices for continuous glucose monitoring (CGM) are currently a major focus of research in the area of diabetes management. It is envisioned that such devices will have the ability to alert a diabetes patient (or the parent or medical care giver of a diabetes patient) of impending hypoglycemic/hyperglycemic events and thereby enable the patient to avoid extreme hypoglycemic/hyperglycemic excursions as well as minimize deviations outside the normal glucose range, thus preventing both life-threatening events and the debilitating complications associated with diabetes. It is anticipated that CGM devices will utilize constant feedback of analytical information from a glucose sensor to activate an insulin delivery pump, thereby ultimately realizing the concept of an artificial pancreas. Depending on whether the CGM device penetrates/breaks the skin and/or the sample is measured extracorporeally, these devices can be categorized as totally invasive, minimally invasive, and noninvasive. In addition, CGM devices are further classified according to the transduction mechanisms used for glucose sensing (i.e., electrochemical, optical, and piezoelectric). However, at present, most of these technologies are plagued by a variety of issues that affect their accuracy and long-term performance. This article presents a critical comparison of existing CGM technologies, highlighting critical issues of device accuracy, foreign body response, calibration, and miniaturization. An outlook on future developments with an emphasis on long-term reliability and performance is also presented.

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“…Some device prototypes have been developed based on this approach, and one of them also reached the market [2,13,14], but it was withdrawn and the company filed for bankruptcy [15]. A new company seems to be currently working on a similar device [16,17], but at the moment no device is on the market.…”

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confidence: 99%

Impedance spectroscopy of solutions at physiological glucose concentrations

Tura¹,

Sbrignadello²,

Barison³

et al. 2007

Biophysical Chemistry

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Impedance spectroscopy has been proposed as possible approach for non-invasive glycaemia monitoring. However, few quantitative data are reported about impedance variations related to glucose concentration variations, especially below the MHz band. Furthermore, it is not clear whether glucose directly affects the impedance parameters or only indirectly by inducing biochemical phenomena. We investigated the impedance variations in glucosewater, glucose-sodium chloride, and glucose-blood samples, for increasing glucose values (up to 300 mg/dl). In all the frequency range (0.1-10 7 Hz) glucose-water samples showed impedance modulus increases for increasing glucose values (up to 135%). In blood and sodium chloride samples the impedance modulus showed only slight variations (2% and 1.4%), but again in wide frequency ranges. Therefore: i) glucose directly affects the impedance parameters of solutions; ii) effects are more relevant at frequencies below the MHz band; iii) the influence on the impedance is decreased in high conductivity solutions, but still clearly present.

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Non-invasive glucose monitoring in patients with diabetes: A novel system based on impedance spectroscopy

Cited by 131 publications

References 30 publications

An analog front-end enables electrical impedance spectroscopy system on-chip for biomedical applications

An analog front-end enables electrical impedance spectroscopy system on-chip for biomedical applications

Technologies for Continuous Glucose Monitoring: Current Problems and Future Promises

Impedance spectroscopy of solutions at physiological glucose concentrations

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