Non-invasive grading of primary brain tumours: Results of a comparative study between SPET with123I-?-methyl tyrosine and PET with18F-deoxyglucose

Woesler, Burkhard; Kuwert, Torsten; Morgenroth, C.; Matheja, Peter; Palkovic, S; Schäfers, Michael; Vollet, B.; Schäfers, Klaus P.; Lerch, H; Brandau, Wolfgang; Samnick, Samuel; Wassmann, H.; Schober, Otmar

doi:10.1007/bf00881816

Cited by 33 publications

(7 citation statements)

References 29 publications

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“…As in other studies of gliomas in general, or astrocytomas in particular (25,58,59), features of elevated metabolism were more likely to be seen in high-grade gliomas with an oligodendroglial component, with 201 Tl uptake being more strongly correlated with histopathological grade than 18 F-FDG uptake. Thus, uptake of 201 Tl, being lower in normal brain than uptakes of 18 F-FDG, and requiring blood-brain barrier breakdown, provides a clearer indication of histopathological grade.…”

Section: Discussionsupporting

confidence: 49%

Correlation of Molecular Genetics with Molecular and Morphological Imaging in Gliomas with an Oligodendroglial Component

Walker

Plessis

Fildes

et al. 2004

Clinical Cancer Research

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Purpose: Since the recognition that oligodendrogliomas may be chemosensitive, their diagnosis and clinical management has become highly controversial. Histopathology diagnosis remains challenging and new tools such as molecular genetics or molecular imaging require evaluation.Experimental Conclusions: In this study, dissociation of uptake of contrast agents and radiotracers suggests independent deregulation of the blood-brain barrier breakdown and metabolism during disease progression of oligodendroglial neoplasms, and the association of elevated metabolism with 1p/19q loss, particularly in low-grade tumors, may have implications for clinical management.

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Section: Discussionsupporting

confidence: 49%

Correlation of Molecular Genetics with Molecular and Morphological Imaging in Gliomas with an Oligodendroglial Component

Walker

Plessis

Fildes

et al. 2004

Clinical Cancer Research

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“…Both positive and inverse correlations can be found between metabolic responses and survival, making these data inconclusive so far. In a more recent study, methionine is found to be superior to FDG in monitoring the treatment effects in low-grade astrocytomas [97].…”

Section: Evaluation Of Therapy By Positron Emission Tomographymentioning

confidence: 98%

Molecular Imaging of Brain Tumors: A Bridge Between Clinical and Molecular Medicine?

2007

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As the research on cellular changes has shed invaluable light on the pathophysiology and biochemistry of brain tumors, clinical and experimental use of molecular imaging methods is expanding and allows quantitative assessment. The term molecular imaging is defined as the in vivo characterization and measurement of biologic processes at the cellular and molecular level. Molecular imaging sets forth to probe the molecular abnormalities that are the basis of disease rather than to visualize the end effects of these molecular alterations and, therefore, provides different additional biochemical or molecular information about primary brain tumors compared to histological methods "classical" neuroradiological diagnostic studies. Common clinical indications for molecular imaging contain primary brain tumor diagnosis and identification of the metabolically most active brain tumor reactions (differentiation of viable tumor tissue from necrosis), prediction of treatment response by measurement of tumor perfusion, or ischemia. The interesting key question remains not only whether the magnitude of biochemical alterations demonstrated by molecular imaging reveals prognostic value with respect to survival, but also whether it identifies early disease and differentiates benign from malignant lesions. Moreover, an early identification of treatment success or failure by molecular imaging could significantly influence patient management by providing more objective decision criteria for evaluation of specific therapeutic strategies. Specially, as molecular imaging represents a novel technology for visualizing metabolism and signal transduction to gene expression, reporter gene assays are used to trace the location and temporal level of expression of therapeutic and endogenous genes. Molecular imaging probes and drugs are being developed to image the function of targets without disturbing them and in mass amounts to modify the target's function as a drug. Molecular imaging helps to close the gap between in vitro and in vivo integrative biology of disease.

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“…A significant correlation between tumor uptake of MET and survival has also been found in low-grade gliomas [115]. A higher IMT uptake in high-grade gliomas than in low-grade gliomas was described [67,146]. However, IMT-SPECT does not significantly add to the accuracy of MRI in determining the tumor grade [117].…”

Section: Brain Tumors Gliomas Amino Acid Pet and Spect In The Diagnosmentioning

confidence: 87%

Positron Emission Tomography for Radiation Treatment Planning

et al. 2005

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Non-invasive grading of primary brain tumours: Results of a comparative study between SPET with123I-?-methyl tyrosine and PET with18F-deoxyglucose

Cited by 33 publications

References 29 publications

Correlation of Molecular Genetics with Molecular and Morphological Imaging in Gliomas with an Oligodendroglial Component

Correlation of Molecular Genetics with Molecular and Morphological Imaging in Gliomas with an Oligodendroglial Component

Molecular Imaging of Brain Tumors: A Bridge Between Clinical and Molecular Medicine?

Positron Emission Tomography for Radiation Treatment Planning

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