Non-invasive investigation of kidney disease in type 1 diabetes by magnetic resonance imaging

Thelwall, Peter E.; Taylor, Roy; Marshall, Sally M.

doi:10.1007/s00125-011-2163-z

Cited by 19 publications

(11 citation statements)

References 37 publications

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“…Assessment of kidney size and volume in the context of chronic kidney disease associated with cardiovascular risk profiles has been of long-standing interest with contradictory results [27][28][29][30][31]. In diabetic nephropathy pre-clinical studies show an increase of kidney volume even preceding hyperfiltrative stages [32][33][34].…”

Section: Discussionmentioning

confidence: 99%

Renal and renal sinus fat volumes as quantified by magnetic resonance imaging in subjects with prediabetes, diabetes, and normal glucose tolerance

Notohamiprodjo

Goepfert

Will³

et al. 2020

PLoS ONE

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We hypothesize that MRI-based renal compartment volumes, particularly renal sinus fat as locally and potentially independently acting perivascular fat tissue, increase with glucose intolerance. We therefore analyze the distribution of renal volumes in individuals with normal glucose levels and prediabetic and diabetic individuals and investigate potential associations with other typical cardiometabolic biomarkers. Material and methods The sample comprised N = 366 participants who were either normoglycemic (N = 230), had prediabetes (N = 87) or diabetes (N = 49), as determined by Oral Glucose Tolerance Test. Other covariates were obtained by standardized measurements and interviews. Wholebody MR measurements were performed on a 3 Tesla scanner. For assessment of the kidneys, a coronal T1w dual-echo Dixon and a coronal T2w single shot fast spin echo sequence were employed. Stepwise semi-automated segmentation of the kidneys on the Dixon-sequences was based on thresholding and geometric assumptions generating volumes for the kidneys and sinus fat. Inter-and intra-reader variability were determined on a subset of 40 subjects. Associations between glycemic status and renal volumes were evaluated by linear regression models, adjusted for other potential confounding variables. Furthermore, the association of renal volumes with visceral adipose tissue was assessed by linear regression models and Pearson's correlation coefficient.

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Section: Discussionmentioning

confidence: 99%

Renal and renal sinus fat volumes as quantified by magnetic resonance imaging in subjects with prediabetes, diabetes, and normal glucose tolerance

Notohamiprodjo

Goepfert

Will³

et al. 2020

PLoS ONE

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“…Intrarenal oxygenation can be assessed noninvasively in subjects with type 1 or type 2 diabetes by blood oxygenation level dependent magnetic resonance imaging (BOLD MRI) [11–13]. Inoue et al, especially, demonstrated hypoxia in the renal parenchyma of chronic kidney disease (CKD) patients with or without diabetes, using diffusion-weighted (DW) MRI and BOLDMRI [13], and confirmed intrarenal hypoxia in patients with diabetes, suggesting that factors other than tubulointerstitial alteration (such as loss of peritubular capillaries) determine the degree of hypoxia in the renal cortex [13].…”

Section: Hypoxia In Diabetic Kidneymentioning

confidence: 99%

Hypoxia in Diabetic Kidneys

Takiyama

Haneda

2014

BioMed Research International

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Diabetic nephropathy (DN) is now a leading cause of end-stage renal disease. In addition, DN accounts for the increased mortality in type 1 and type 2 diabetes, and then patients without DN achieve long-term survival compatible with general population. Hypoxia represents an early event in the development and progression of DN, and hypoxia-inducible factor- (HIF-) 1 mediates the metabolic responses to renal hypoxia. Diabetes induces the “fraternal twins” of hypoxia, that is, pseudohypoxia and hypoxia. The kidneys are susceptible to hyperoxia because they accept 20% of the cardiac output. Therefore, the kidneys have specific vasculature to avoid hyperoxia, that is, AV oxygen shunting. The NAD-dependent histone deacetylases (HDACs) sirtuins are seven mammalian proteins, SIRTs 1–7, which are known to modulate longevity and metabolism. Recent studies demonstrated that some isoforms of sirtuins inhibit the activation of HIF by deacetylation or noncatalyzing effects. The kidneys, which have a vascular system that protects them against hyperoxia, unfortunately experience extraordinary hypernutrition today. Then, an unexpected overload of glucose augments the oxygen consumption, which ironically results in hypoxia. This review highlights the primary role of HIF in diabetic kidneys for the metabolic adaptation to diabetes-induced hypoxia.

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“…The BOLD-MRI technique itself has been criticized by some [40, 41], arguing that it is difficult to acquire the same anatomical slices in each participant when repeating the BOLD-MRI exams. However, the intraobserver variability of the cortical and medullary R 2* values is low when performed by an experienced investigator and when using a standardized breath-hold technique [42].…”

Section: Measurement Of Renal Tissue Oxygenation In Humans With Bomentioning

confidence: 99%

Renal Tissue Oxygenation in Essential Hypertension and Chronic Kidney Disease

Pruijm

Hofmann

Vogt

et al. 2013

International Journal of Hypertension

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Animal studies suggest that renal tissue hypoxia plays an important role in the development of renal damage in hypertension and renal diseases, yet human data were scarce due to the lack of noninvasive methods. Over the last decade, blood oxygenation level-dependent magnetic resonance imaging (BOLD-MRI), detecting deoxyhemoglobin in hypoxic renal tissue, has become a powerful tool to assess kidney oxygenation noninvasively in humans. This paper provides an overview of BOLD-MRI studies performed in patients suffering from essential hypertension or chronic kidney disease (CKD). In line with animal studies, acute changes in cortical and medullary oxygenation have been observed after the administration of medication (furosemide, blockers of the renin-angiotensin system) or alterations in sodium intake in these patient groups, underlining the important role of renal sodium handling in kidney oxygenation. In contrast, no BOLD-MRI studies have convincingly demonstrated that renal oxygenation is chronically reduced in essential hypertension or in CKD or chronically altered after long-term medication intake. More studies are required to clarify this discrepancy and to further unravel the role of renal oxygenation in the development and progression of essential hypertension and CKD in humans.

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Non-invasive investigation of kidney disease in type 1 diabetes by magnetic resonance imaging

Abstract: ) MRI were performed, before and during water diuresis. Contrast-enhanced MRI was performed at baseline urine flow rate. Renal artery flow, renal vascular resistance (RVR), cortical and medullary volumes, and R 2 * were determined.

Cited by 19 publications

References 37 publications

Renal and renal sinus fat volumes as quantified by magnetic resonance imaging in subjects with prediabetes, diabetes, and normal glucose tolerance

Renal and renal sinus fat volumes as quantified by magnetic resonance imaging in subjects with prediabetes, diabetes, and normal glucose tolerance

Hypoxia in Diabetic Kidneys

Renal Tissue Oxygenation in Essential Hypertension and Chronic Kidney Disease

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