Non-invasive, non-pharmacological/bio-technological interventions towards neurorestoration upshot after ischemic stroke, in adults—systematic, synthetic, literature review

Onose, Gelu; Anghelescu, Aurelian; Blendea, Corneliu Dan; Ciobanu, Vlad; Daia, Cristina Octaviana; Firan, Florentina Carmen; Munteanu, Constantin; Oprea, Mihaela; Spinu, Aura; Popescu, Cristina

doi:10.52586/5020

Cited by 10 publications

(3 citation statements)

References 231 publications

(314 reference statements)

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“…In the last decade, huge scientific research efforts have been deployed to acquire a better understanding of CNS lesions and to significantly improve the clinical-function outcomes, including management, because of their dreadful, multiplane life-threatening, and disabling potential, but at least for now, there are still no medical (of any kind) interventions [ 17 , 18 , 141 ] able to cure or decisively contribute to their healing [ 14 , 140 ].…”

Section: Discussionmentioning

confidence: 99%

“…On the other hand, in human adults, vascular disorders (such as stroke) are risk factors for neurodegenerative diseases [ 15 ], like Parkinson’s disease [ 16 ], dementia (and other cognitive impairments). In addition, there are also innate metabolic disorders that affect the CNS’s functioning, such as hyperhomocysteinemia (a consequence of impaired homocysteine metabolism or other cofactors involved in its degradation), which is an independent risk factor for stroke [ 17 , 18 ] occurrence [ 19 , 20 ].…”

Section: Introductionmentioning

confidence: 99%

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Considerations about Hypoxic Changes in Neuraxis Tissue Injuries and Recovery

Stoica

Bleoţu²,

Ciobanu

et al. 2022

Biomedicines

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Hypoxia represents the temporary or longer-term decrease or deprivation of oxygen in organs, tissues, and cells after oxygen supply drops or its excessive consumption. Hypoxia can be (para)-physiological—adaptive—or pathological. Thereby, the mechanisms of hypoxia have many implications, such as in adaptive processes of normal cells, but to the survival of neoplastic ones, too. Ischemia differs from hypoxia as it means a transient or permanent interruption or reduction of the blood supply in a given region or tissue and consequently a poor provision with oxygen and energetic substratum-inflammation and oxidative stress damages generating factors. Considering the implications of hypoxia on nerve tissue cells that go through different ischemic processes, in this paper, we will detail the molecular mechanisms by which such structures feel and adapt to hypoxia. We will present the hypoxic mechanisms and changes in the CNS. Also, we aimed to evaluate acute, subacute, and chronic central nervous hypoxic-ischemic changes, hoping to understand better and systematize some neuro-muscular recovery methods necessary to regain individual independence. To establish the link between CNS hypoxia, ischemic-lesional mechanisms, and neuro-motor and related recovery, we performed a systematic literature review following the” Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA”) filtering method by interrogating five international medical renown databases, using, contextually, specific keywords combinations/”syntaxes”, with supplementation of the afferent documentation through an amount of freely discovered, also contributive, bibliographic resources. As a result, 45 papers were eligible according to the PRISMA-inspired selection approach, thus covering information on both: intimate/molecular path-physiological specific mechanisms and, respectively, consequent clinical conditions. Such a systematic process is meant to help us construct an article structure skeleton giving a primary objective input about the assembly of the literature background to be approached, summarised, and synthesized. The afferent contextual search (by keywords combination/syntaxes) we have fulfilled considerably reduced the number of obtained articles. We consider this systematic literature review is warranted as hypoxia’s mechanisms have opened new perspectives for understanding ischemic changes in the CNS neuraxis tissue/cells, starting at the intracellular level and continuing with experimental research to recover the consequent clinical-functional deficits better.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Considerations about Hypoxic Changes in Neuraxis Tissue Injuries and Recovery

Stoica

Bleoţu²,

Ciobanu

et al. 2022

Biomedicines

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“…Hypothermia can provide various benefits in rehabilitation and neurocritical care [4]. Hypothermia treatment can affect the regulation of the expression of the insulin-like growth factor 1 gene [33]. It has been known that lithium chloride can prevent hypothermia by inhibiting the Tau hyperphosphorylation and enhancing the expression of catenin protein.…”

Section: Ischemic Stroke Pathological Context and Lithium Interventionsmentioning

confidence: 99%

Lithium Biological Action Mechanisms after Ischemic Stroke

Munteanu

Rotariu

Turnea

et al. 2022

Life

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Lithium is a source of great scientific interest because although it has such a simple structure, relatively easy-to-analyze chemistry, and well-established physical properties, the plethora of effects on biological systems—which influence numerous cellular and molecular processes through not entirely explained mechanisms of action—generate a mystery that modern science is still trying to decipher. Lithium has multiple effects on neurotransmitter-mediated receptor signaling, ion transport, signaling cascades, hormonal regulation, circadian rhythm, and gene expression. The biochemical mechanisms of lithium action appear to be multifactorial and interrelated with the functioning of several enzymes, hormones, vitamins, and growth and transformation factors. The widespread and chaotic marketing of lithium salts in potions and mineral waters, always at inadequate concentrations for various diseases, has contributed to the general disillusionment with empirical medical hypotheses about the therapeutic role of lithium. Lithium salts were first used therapeutically in 1850 to relieve the symptoms of gout, rheumatism, and kidney stones. In 1949, Cade was credited with discovering the sedative effect of lithium salts in the state of manic agitation, but frequent cases of intoxication accompanied the therapy. In the 1960s, lithium was shown to prevent manic and also depressive recurrences. This prophylactic effect was first demonstrated in an open-label study using the “mirror” method and was later (after 1970) confirmed by several placebo-controlled double-blind studies. Lithium prophylaxis was similarly effective in bipolar and also unipolar patients. In 1967, the therapeutic value of lithemia was determined, included in the range of 0.5–1.5 mEq/l. Recently, new therapeutic perspectives on lithium are connected with improved neurological outcomes after ischemic stroke. The effects of lithium on the development and maintenance of neuroprotection can be divided into two categories: short-term effects and long-term effects. Unfortunately, the existing studies do not fully explain the lithium biological action mechanisms after ischemic stroke.

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Neurologic Music Therapy's Impact on Neurological Disorders

Wei,

Qiao

2024

J of Neuroscience Research

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Neurologic music therapy (NMT) represents a groundbreaking, interdisciplinary approach that combines the therapeutic properties of music with neuroscientific principles to treat a range of neurological and psychiatric conditions. This interdisciplinary approach, increasingly recognized in clinical and research settings, leverages advances in neuroimaging to explore how music affects the structure and activity of the brain. This review provides an in‐depth exploration of the multifaceted effects of NMT on brain function, highlighting its role in promoting neuroplastic changes and enhancing cognitive, emotional and motor functions in diverse patient groups. This review consolidates current knowledge on NMT and provides insights into how music affects brain structure and function and the mechanisms of action. The article then discusses the application and research results of NMT in various diseases such as stroke, Alzheimer's disease and Parkinson's disease. Its potential in personalizing therapeutic interventions and its ability to improve treatment access and effectiveness in various settings are highlighted.

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Non-invasive, non-pharmacological/bio-technological interventions towards neurorestoration upshot after ischemic stroke, in adults—systematic, synthetic, literature review

Abstract: Introduction 3. Materials and methods 4. Results 5. Discussion and conclusions 6. Author contributions 7. Ethics approval and consent to participate 8. Acknowledgment 9. Funding 10. Conflict of interest 11. References

Cited by 10 publications

References 231 publications

Considerations about Hypoxic Changes in Neuraxis Tissue Injuries and Recovery

Considerations about Hypoxic Changes in Neuraxis Tissue Injuries and Recovery

Lithium Biological Action Mechanisms after Ischemic Stroke

Neurologic Music Therapy's Impact on Neurological Disorders

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