Non-invasive optical estimate of tissue composition to differentiate malignant from benign breast lesions: A pilot study

Taroni, Paola; Paganoni, Anna Maria; Ieva, Francesca; Pifferi, Antonio; Quarto, Giovanna; Abbate, Francesca; Cassano, Enrico; Cubeddu, Rinaldo

doi:10.1038/srep40683

Cited by 66 publications

(70 citation statements)

References 54 publications

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“…The absorption coefficient at 976 nm reflected the relative amount of water in the phantom, whereas the absorption coefficient at 936 nm did not necessarily reflect the relative amount of lipid in the phantom. Taroni et al used seven wavelengths from 635 to 1060 nm to measure collagen as an important biomarker in a pathological classification [32]. They stated that 635 and 1060 nm were very effective wavelengths for collagen identification.…”

Section: Discussionmentioning

confidence: 99%

“…They also reported that the presence or absence of collagen affects the calculation of other parameters [33]. The level of collagen varies with age, body mass index (BMI), and breast density [17,34], and is reported to be involved in tumor development and progression [32]. It is difficult to measure collagen with the wavelengths of 760-1000 nm used in this study, as the absorption of collagen is lower than that of water and lipid at those wavelengths, and the spectral peak positions of lipid and collagen are similar within this wavelength range [33].…”

Section: Discussionmentioning

confidence: 99%

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Comparison of Lipid and Water Contents by Time-domain Diffuse Optical Spectroscopy and Dual-energy Computed Tomography in Breast Cancer Patients

et al. 2019

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We previously compared time-domain diffuse optical spectroscopy (TD-DOS) with magnetic resonance imaging (MRI) using various water/lipid phantoms. However, it is difficult to conduct similar comparisons in the breast, because of measurement differences due to modality-dependent differences in posture. Dual-energy computed tomography (DECT) examination is performed in the same supine position as a TD-DOS measurement. Therefore, we first verified the accuracy of the measured fat fraction of fibroglandular tissue in the normal breast on DECT by comparing it with MRI in breast cancer patients (n = 28). Then, we compared lipid and water signals obtained in TD-DOS and DECT from normal and tumor-tissue regions (n = 16). The TD-DOS breast measurements were carried out using reflectance geometry with a source-detector separation of 3 cm. A semicircular region of interest (ROI), with a transverse diameter of 3 cm and a depth of 2 cm that included the breast surface, was set on the DECT image. Although the measurement area differed between the modalities, the correlation coefficients of lipid and water signals between TD-DOS and DECT were rs = 0.58 (p < 0.01) and rs = 0.90 (p < 0.01), respectively. These results indicate that TD-DOS captures the characteristics of the lipid and water contents of the breast.The validity of NIRS systems has generally been verified using tissue simulating phantoms such as intralipid-based aqueous phantoms [8,9] and resin-based hard phantoms [10], while phantoms with various lipid and water contents have been proposed in previous studies [11][12][13][14]. Merrit et al. and Ohmae et al. used such phantoms to compare lipid and water measurements between a diffuse optical spectroscopy (DOS) system and magnetic resonance imaging (MRI), which was defined as the "gold standard" technique [11,14]. In those studies, the authors confirmed that MRI and DOS measurements of water/lipid ratios in phantoms were almost identical. Studies using breast phantoms [13] and simulations [15] have also been conducted, but the structure of the living body is more complicated. Several studies have reported on the relationship between DOS parameters and breast density on MRI and their link with breast cancer risk [3,16,17]. Although previous studies have compared DOS with other modalities such as MRI, there have been no reports comparing DOS with other modalities in the direct measurement of lipid and water signals in the human breast. Although we previously compared lipid and water measurements of the contents of a phantom between MRI and time-domain diffuse optical spectroscopy (TD-DOS) [14], comparison of these parameters in living humans is difficult, because the measurement postures required in the two modalities differ: MRI measurement is conducted with the subject in a prone (downward facing) position, while the subject is generally in a supine (upward facing) or standing position for the DOS measurement.Computed tomography (CT) is a cross-sectional, high-resolution, three-dimensional diagnostic imaging modality ...

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Comparison of Lipid and Water Contents by Time-domain Diffuse Optical Spectroscopy and Dual-energy Computed Tomography in Breast Cancer Patients

et al. 2019

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“…Furthermore, a 12-channel TD-NIRS system for optical mammography with a hand-held probe shown in Figure 11b was developed to be used at a bed side [53]. Another TD-NIRS system for optical mammography, as shown in Figure 11c, was developed by a group from Italy to obtain TR transmittance images of compressed breasts [54]. The results of these systems are briefly described later in Sections 5.2.1 and 5.3.5.…”

Section: Td-dot and Td-nirs Systems For Optical Mammographymentioning

confidence: 99%

“…Photos of (a) the 48-channel TD-DOT for optical mammography [52]; (b) the 12-channel TD-NIRS system for optical mammography with a hand-held probe [53], and (c) the transmittance Figure 11. Photos of (a) the 48-channel TD-DOT for optical mammography [52]; (b) the 12-channel TD-NIRS system for optical mammography with a hand-held probe [53], and (c) the transmittance TD-NIRS imaging system for optical mammography with breast compression [54]. (b) Reproduced from Reference [53].…”

Section: Td-dot and Td-nirs Systems For Optical Mammographymentioning

confidence: 99%

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Time-Domain Near-Infrared Spectroscopy and Imaging: A Review

2019

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This article reviews the past and current statuses of time-domain near-infrared spectroscopy (TD-NIRS) and imaging. Although time-domain technology is not yet widely employed due to its drawbacks of being cumbersome, bulky, and very expensive compared to commercial continuous wave (CW) and frequency-domain (FD) fNIRS systems, TD-NIRS has great advantages over CW and FD systems because time-resolved data measured by TD systems contain the richest information about optical properties inside measured objects. This article focuses on reviewing the theoretical background, advanced theories and methods, instruments, and studies on clinical applications for TD-NIRS including some clinical studies which used TD-NIRS systems. Major events in the development of TD-NIRS and imaging are identified and summarized in chronological tables and figures. Finally, prospects for TD-NIRS in the near future are briefly described.

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Single probe diffuse reflectance spectroscopy to assess the effect of sarcopoterium spinosum treatment on the cerebral tissue properties of ApoE knockout mouse

Shemesh

Rozenberg

Rosenzweig

et al. 2020

Journal of Biophotonics

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In this work, diffuse near‐infrared light reflectance spectroscopy based on a single optical probe, contains central single collection fiber surrounded by a circular array of illumination fibers, was used to quantify cerebral tissue properties in ApoE knockout mice following Sarcopoterium spinosum treatment. Sarcopoterium spinosum, also known as Thorny burnet, is a Mediterranean plant widely used as a traditional therapy for the treatment of a variety of pathologies, primarily type 2 diabetes mellitus (T2D). While it's efficacy in the treatment of T2D, and of other components of metabolic syndrome, have already been validated by us, the aim of this study was to investigate the effects of Sarcopoterium spinosum extract (SSE) on dyslipidemia and vascular functions. We utilized ApoE deficient mice (ApoE−/−, Atherosclerosis‐prone apolipoprotein E‐deficient), who have a severe impairment in plasma lipoprotein clearance and thus develop alterations in blood lipid profile and are highly susceptible to atherogenic plaque formation. A total of 34 male mice were divided into five groups representing various genetic, dietary, and treatment configurations. Optical measurements were used to assess changes in diffused reflectance spectra, optical properties (absorption and scattering), and cerebral tissue chromophore contents. Specifically, significant improvement in cerebral hemoglobin level was observed in ApoE KO mice, fed an artherogenic diet (ATD), upon SSE treatment. Biochemical and histological analyses of ApoE−/−ATD mice showed elevated body weight and a high level of blood triglycerides, free fatty acids and cholesterol. In contrast, in SSE treated mice improvement was observed, suggesting beneficial effects of SSE. In ApoE−/−ATD mice group a higher levels of deoxyhemoglobin was monitored indicating that the rate of oxygen release to the tissue is low. This was supported by decrease in oxygen saturation. It was also shown a reduction in water content in the brain of ApoE KO. Mice fed with the atherogenic diet demonstrated increased water content as compared to STD‐fed ApoE KO mice, while SSE administration reversed the effect of the diet. To our knowledge, no such study has been reported before.

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Non-invasive optical estimate of tissue composition to differentiate malignant from benign breast lesions: A pilot study

Cited by 66 publications

References 54 publications

Comparison of Lipid and Water Contents by Time-domain Diffuse Optical Spectroscopy and Dual-energy Computed Tomography in Breast Cancer Patients

Comparison of Lipid and Water Contents by Time-domain Diffuse Optical Spectroscopy and Dual-energy Computed Tomography in Breast Cancer Patients

Time-Domain Near-Infrared Spectroscopy and Imaging: A Review

Single probe diffuse reflectance spectroscopy to assess the effect of sarcopoterium spinosum treatment on the cerebral tissue properties of ApoE knockout mouse

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