Non-invasive optical real-time measurement of total hemoglobin content

Timm, U.; Leen, Gabriel; Lewis, Elfed; McGrath, Denise; Kraitl, J.; Ewald, Hartmut

doi:10.1016/j.proeng.2010.09.153

Cited by 26 publications

(15 citation statements)

References 3 publications

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“…Furthermore, whether it is a commercial product or a prototype of laboratory research, the wavelengths of LED light sources for Hb monitoring devices are not exactly the same and have their own characteristics. According to the previous studies, the number of wavelengths for LEDs used for noninvasive Hb detection ranges from two to nine, while the wavelength range covers substantially 660 nm to 1348 nm [11][12][13][14][15][16][17][18][19]. In fact, the choice of wavelength range is very important.…”

Section: Discussionmentioning

confidence: 99%

“…Based on the PPG method, Timm et al used three wavelengths to design the optical sensor system to measure the Hb concentration, pulse, and oxygenation [1,12]. Soon afterward their improved sensor system was able to determine Hb level by using the water absorption coefficient above 1150 nm [13]. Similarly, Doshi et al developed an optical noncontact type sensor, with the help of which it is possible to measure Hb with two wavelengths, 660 nm and 940 nm [14].…”

Section: Introductionmentioning

confidence: 99%

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Development and Validation of a Photoplethysmography System for Noninvasive Monitoring of Hemoglobin Concentration

Liu

Peng

et al. 2020

Journal of Electrical and Computer Engineering

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Background. Traditional invasive hemoglobin (Hb) detection led to delayed diagnosis, operational inefficiency, incorrect critical decision making, and uncomfortable patient experience. To facilitate real-time total hemoglobin (tHb) monitoring, a portable prototype of a noninvasive Hb detection system was developed, and the accuracy of Hb predicted based on partial least squares (PLS) as well as backpropagation artificial neural network (BP-ANN) models was validated. Results. The prototype was combined with a signal processing circuit and a spectrophotometric probe containing 8 wavelength LEDs light source and photodiode array. Laboratory invasive Hb (Lab_tHb) and spot check Hb measurements with PLS (SpHb_PLS) and BP (SpHb_BP) methods were obtained simultaneously by hematology analyzer and the designed system. The invasive and noninvasive estimates of the Hb levels were analyzed using Spearman correlation as well as Bland–Altman plot and receiver operating characteristic (ROC) curve analysis. A total of 238 volunteers had attempted laboratory invasive and noninvasive spot check Hb measurements. Mean Lab_tHb, SpHb_PLS, and SpHb_BP were 13.6 ± 1.80 g/dL, 13.5 ± 1.07 g/dL, and 13.6 ± 1.06 g/dL, respectively. Noninvasive SpHb_PLS (r = 0.61, p<0.001) and SpHb_BP (r = 0.62, p<0.001) had a strong correlation with invasive tHb values. The Bland–Altman plot showed excellent consistency between the proposed noninvasive methods and laboratory invasive reference. In ROC analysis, PLS and BP models were good at predicting Hb ≥ 12 g/dL with area under the curve of 0.828 and 0.824, respectively. Observed differences between invasive and noninvasive Hb measurements displayed no significant correlation with perfusion index values. Conclusions. The result confirmed that noninvasive Hb monitoring had an excellent correlation with traditional invasive Hb measurement. Furthermore, it is suggested that the developed prototype has the potential for the noninvasive detection of Hb concentration with the methods of PLS and BP-ANN.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Development and Validation of a Photoplethysmography System for Noninvasive Monitoring of Hemoglobin Concentration

Liu

Peng

et al. 2020

Journal of Electrical and Computer Engineering

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“…Opt. Express 17(26) 2009; Timm et al 2010), among which the absorption optical method is one of the most suitable for each day medical practice due to the relative simplicity of its technical realization. Analysis of tendencies of development of optical methods and techniques for the evaluation of hemoglobin concentration shows that the underlying trend is the use of pulse COoximetry method (Deyo et al 2001;Lindner and Exadaktylos 2013), which is based on direct measurement of blood components absorption and thus decreased the error associated with other tissues.…”

Section: Stevenson 2005;mentioning

confidence: 99%

Experimental unit for in vivo measurement of hemoglobin content in blood

et al. 2016

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The experimental unit was developed for non-invasive in vivo measurement of blood hemoglobin concentration based on algorithms of pulse wave signals processing. Experiments were performed with two types of sensors: five-bands sensor (660, 756, 779, 841 and 963 nm) and seven-bands sensor (520, 658, 776, 839, 974, 1348, 1550 nm). Additional bands in infrared region allow to estimate the water concentration and enhance the accuracy of hemoglobin content measurement. The unit was tested on a group of patients with various hematological pathologies. The total number of patients exceeds 200 people and hemoglobin concentration varied in a range 80-170 g/L. Optimal algorithms with minimum variance of the difference between optical and laboratory measurements of hemoglobin content were found. It was shown that the accuracy of the hemoglobin content determination greatly depends on hematocrit.

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“…Various methods [1][2][3][4][5][6][7][8][9] can be used to assess the blood haemoglobin concentration in vivo.…”

Section: Introductionmentioning

confidence: 99%

Choosing the probe radiation wavelengths for noninvasive monitoring of haemoglobin in blood

Давыдкин

Kozlova

Конюхов

et al. 2016

JBPE

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Abstract. The goal of our study was to estimate the accuracy of measuring the blood haemoglobin concentration by means of the pulse CO-oximetry, depending on the probe radiation wavelength. Revealing the combinations of wavelengths, optimal for minimising the measurement error, will allow the formulation of requirements to the instruments for noninvasive assessment of haemoglobin concentration, applicable in wide clinical practice. To solve this problem, we examined a group of haematological patients in the Haematology Department of the Samara State Medical University Clinic with the aim to compare the results obtained using the experimental multiwave system for noninvasive haemoglobin concentration assessment and the results of the clinical blood analysis.

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Non-invasive optical real-time measurement of total hemoglobin content

Cited by 26 publications

References 3 publications

Development and Validation of a Photoplethysmography System for Noninvasive Monitoring of Hemoglobin Concentration

Development and Validation of a Photoplethysmography System for Noninvasive Monitoring of Hemoglobin Concentration

Experimental unit for in vivo measurement of hemoglobin content in blood

Choosing the probe radiation wavelengths for noninvasive monitoring of haemoglobin in blood

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