Non-Invasive Prediction of Coronary Artery Disease by Multiple Abdominal Fat and Anthropometric Indices: Revisit

Abstract

The aim of this study was to evaluate the efficiency of multiple abdominal fat indices measured by ultrasound and anthropometric indices to predict the presence and severity of coronary artery disease (CAD) assessed by coronary angiography. Patients and Methods: All participants subjected to clinical and laboratory assessments. Anthropometric measurements were taken followed by an ultrasound examination to measure fat thickness at multiple abdominal areas. Lastly, selective coronary angiography performed by the Judkins technique. Statistical analysis was performed to detect the association between all variables and CAD, followed by regression analysis, and Odds ratio (OR) was used to quantifies the strength of the association between two events. Results: From the abdominal indices, the posterior right perinephric fat thickness (PRPFT) above the best cutoff value had the highest hazard ratio (HR: 12.3, p = 0.001), followed by visceral adipose tissue volume (VAT) (HR: 10.7, p < 0.001), waist circumference (WC) (HR: 6.7, p = 0.001), visceral fat thickness (VFT) (HR: 5.7, p = 0.002), and body mass index (BMI) (HR: 5.48, p = 0.017). It also showed an independent association between the severity of CAD and WC (HR: 4.28, p = 0.012), VFT (HR: 3.7, p = 0.032), VAT (HR: 3.7, p = 0.034), and waist to height ratio (WHtR) (HR: 3.3, p = 0.033). Conclusion: Posterior perinephric fat thickness and visceral adipose tissue volume measured by ultrasound are strong noninvasive predictors for coronary artery disease, followed by body mass index, waist circumference and visceral fat thickness.

Recent trends in anthropometric indices and lipoprotein indices as non-invasive biomarkers of atherosclerosis and coronary heart diseases in general population of Amritsar city

“…In the present study all these indices were higher in cases than healthy controls as in agreement with these previous studies. Waist hip ratio, waist height ratio and body mass index were positively associated with LDL-C levels which may further contribute to CAD/CHD risk as according to studies (Chitra et al 2012;Wang et al 2018;Hazem et al 2021). Body mass index, waist circumference and waist height ratio are good noninvasive predictors of severity of coronary artery disease risk (Hazem et al 2021) while body adiposity index and body roundness index proved to be best indicators of estimating CHD risk (Wang et al 2018).…”

“…Waist hip ratio, waist height ratio and body mass index were positively associated with LDL-C levels which may further contribute to CAD/CHD risk as according to studies (Chitra et al 2012;Wang et al 2018;Hazem et al 2021). Body mass index, waist circumference and waist height ratio are good noninvasive predictors of severity of coronary artery disease risk (Hazem et al 2021) while body adiposity index and body roundness index proved to be best indicators of estimating CHD risk (Wang et al 2018). To the best of our knowledge, no studies have reported the association of total body fat mass and body roundness index with LDL-C and atherogenic index.…”

“…The BAI is used to nd the percent body fat from measurements of hip circumference of height (Bergman et al 2011). Lipoprotein indices have shown more predictable considerations for heart diseases compared to values of lipoproteins per se (Calling et al 2021;Hazem et al 2021). Among these are TG/HDL TC/HDL and LDL-C/HDL-C ratio.…”

A importância dos índices antropométricos na prevenção de risco cardiovascular

“…Além disso, conforme Hazem 6 , estudos provaram que a adiposidade visceral desempenha um papel importante no desenvolvimento de doenças e distúrbios relacionados à obesidade mais do que a obesidade geral, sugerindo o importante papel da gordura visceral nas doenças cardiovasculares e metabólicas.…”