Non-invasive Prefrontal/Frontal Brain Stimulation Is Not Effective in Modulating Food Reappraisal Abilities or Calorie Consumption in Obese Females

Grundeis, Felicitas; Brand, Cristin; Kumar, Saurabh; Rullmann, Michael; Mehnert, Jan; Pleger, Burkhard

doi:10.3389/fnins.2017.00334

Cited by 15 publications

(35 citation statements)

References 83 publications

(160 reference statements)

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“…Controversial findings due to methodological differences deserve more research in this field. In addition, the discrepancy between the study by Grundeis et al 25 and other more positive findings 24 demands further studies, for example, combining repetitive DCS instead of just one single session. In this regard, Ljubisavljevic et al, using repeated tDCS, reduced craving even 30 days after the intervention.…”

Section: Discussionmentioning

confidence: 78%

“… 17 , 69 Generally, these studies have found a reduction in the calorie intake per day, mood improvements, a reduction in ED cognitions, and a reduction in food craving. Nevertheless, the study by Grundeis et al 25 does not support the notion of prefrontal/frontal DCS as a promising treatment option for obesity. Controversial findings due to methodological differences deserve more research in this field.…”

Section: Discussionmentioning

confidence: 93%

“…Another study based on tDCS in obesity was developed by Grundeis et al, 25 with a sample of 25 females. In this case, anodal, cathodal, and sham tDCS to the LDLPFC and contralateral frontal operculum were applied by means of single session.…”

Section: Resultsmentioning

confidence: 99%

“…In some cases, patients suffered from refractory AN 15 or intractable obesity (failed bariatric surgery), 23 suffered from PTSD, 36 were considered chronic or with treatment resistance, 22 (eg, without improvement under SSRI treatment), 32 and showed a wide range of BMI. 31 Healthy obese participants 24 , 25 or healthy individuals who reported frequent food cravings 17 , 27 , 28 took part in the studies, and sometimes the illness duration showed a very wide range (eg, 4–528 months). 26 …”

Section: Resultsmentioning

confidence: 99%

“…In most of the included studies, the authors obtained some positive results, despite three studies reporting no significant improvement in binging and purging symptoms, 32 no effects either on the ability to modulate the desire for visually presented foods or on calorie consumption, 25 and no effects on selective attention after applying TMS. 35 …”

Section: Resultsmentioning

confidence: 99%

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Neuromodulation in eating disorders and obesity: a promising way of treatment?

Jáuregui‐Lobera¹,

Martínez-Quiñones²

2018

NDT

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Neuromodulation can affect the functioning of the central nervous system (CNS), and emotional/eating behavior is an exciting facet of that functioning. Therefore, it would be possible to offer an alternative (or complement) treatment to psychotropic medications and different psychological and nutritional approaches to both eating disorders (EDs) and obesity. Although there are a number of publications in these areas, a systematic review has not been conducted to date. Abstracts, letters, conference reports, dissertations, and reviews were excluded. Clinical trials and controlled human clinical trials were filtered and included in this study. Articles included were based on the population suffering from anorexia nervosa, bulimia nervosa, binge ED, overweight, and obesity. No restrictions were placed on the sample size. Only trials investigating the effect of neuromodulation by means of deep brain stimulation (DBS), transcranial direct current stimulation (tDCS), and transcranial magnetic stimulation (TMS) were included. The following databases were used to conduct the search: MEDLINE/ PubMed, PsycINFO, PsycArticles, and Cochrane (Search Trials, CENTRAL). Study selection was performed following the PRISMA process (PRISMA 2009 Checklist). The total number of participants in all the trials was 562 (DBS, 25; tDCS, 138; TMS, 399; range, 3–90; median, 23.5). As a result, 50% of the studies had samples of between 14 and 38 participants. Neuro-modulation in ED seems to have certain clinical potential, and therefore, this is a promising area for further research. Developments in ED neuromodulation will be linked to neuroimaging to identify potential stimulation targets and possible biomarkers of treatment response. To date, TMS and/or direct current stimulation (DCS) is not the first-line treatment yet, but it could become a preferred option of treatment in the future. Further studies should avoid small sample sizes and the use of different methodologies. Currently, neuromodulation techniques are in the experimental phase, and they are not an evidence-based treatment for ED.

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Section: Discussionmentioning

confidence: 78%

Section: Discussionmentioning

confidence: 93%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 3 more Smart Citations

Neuromodulation in eating disorders and obesity: a promising way of treatment?

Jáuregui‐Lobera¹,

Martínez-Quiñones²

2018

NDT

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Neurobiological regulation of eating behavior: Evidence based on non-invasive brain stimulation

Ester

Kullmann

2021

Rev Endocr Metab Disord

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The prefrontal cortex is appreciated as a key neurobiological player in human eating behavior. A special focus is herein dedicated to the dorsolateral prefrontal cortex (DLPFC), which is critically involved in executive function such as cognitive control over eating. Persons with obesity display hypoactivity in this brain area, which is linked to overconsumption and food craving. Contrary to that, higher activity in the DLPFC is associated with successful weight-loss and weight-maintenance. Transcranial direct current stimulation (tDCS) is a non-invasive neurostimulation tool used to enhance self-control and inhibitory control. The number of studies using tDCS to influence eating behavior rapidly increased in the last years. However, the effectiveness of tDCS is still unclear, as studies show mixed results and individual differences were shown to be an important factor in the effectiveness of non-invasive brain stimulation. Here, we describe the current state of research of human studies using tDCS to influence food intake, food craving, subjective feeling of hunger and body weight. Excitatory stimulation of the right DLPFC seems most promising to reduce food cravings to highly palatable food, while other studies provide evidence that stimulating the left DLPFC shows promising effects on weight loss and weight maintenance, especially in multisession approaches. Overall, the reported findings are heterogeneous pointing to large interindividual differences in tDCS responsiveness.

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